Lifeboat Foundation

Lifespan.io is running a SENS fundraiser to aid research into Mitochondrial repair. This is a new fundraiser platform to help get important regenerative medicine research funded and underway. Let us hope this is the start of how research could be funded and that it opens up faster progress.

Engineering backup copies of mitochondrial genes to place in the nucleus of the cell, aiming to prevent age-related damage and restore lost mitochondrial function.

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https://www.youtube.com/watch?v=y5zQpZ1BqXs&feature=youtu.be&app=desktop

An interesting little Bioviva clip about their upcoming gene therapy work.

CEO Liz Parrish discusses BioViva and gene therapy…. Diseases of aging beware.

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Ever since the free radical theory of aging was conceived in the 1950s, antioxidants have been a buzzword in health — saturating the cosmetic industry and contributing to a smoothie blending, supplement popping boom.

Ever since the free radical theory of aging was conceived in the 1950s, antioxidants have been a buzz word in health — saturating the cosmetic industry and contributing to a smoothie blending, supplement popping boom. While antioxidants can certainly play an essential role in health, there is growing evidence that additional supplementation has limited benefit and can actually be harmful in some cases.

Aging has yet to be ascribed to one, singular cause and the free radical theory has struggled to prove itself. While in some organisms reducing oxidative stress can prove beneficial and increasing mitochondria targeted catalase (an important antioxidant enzyme) production in mice showed a modest increase in lifespan, when important enzymes were knocked out in C. elegans (a model organism) there was curiously no reduction and reducing expression of various antioxidant mechanisms in mice also failed to reduce lifespan. While a certain amount of vitamins and antioxidant intake is necessary, as many are co-factors in essential reactions, it seems that aside from nutritional value there is little consensus regarding additional benefits.

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Checkout the latest Longevity Reporter Newsletter (15th August, 2015), covering this week’s top news in health, aging, longevity

This week: ‘Danielle’ — An Eye Opening Simulation Of The Aging Process; How Does Chronic Inflammation Lead To Cancer?; Low Inflammation and Telomere Maintenance Predict Healthy Longevity; 3-D Printing: Could Downloadable Medicine Be The Future?; And more.

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“A protein found in the blood of young animals called GDF-11 is inducing systemic rejuvenation effects on bone, muscle, heart, blood vessels, and brains of older animals.

“GDF” stands for growth differentiating factor. It functions to turn “on” senescent stem cells, which results in a restoration of youthful structure and function to senile tissues. This same protein (GDF-11) is found in young humans as well as animals.

Harvard, Stanford, and other universities are conducting remarkable studies showing age reversal in animal models. Researchers from these centers of medical innovation are optimistic that this approach might be applicable to humans.”

Continue reading “Report: Human Age Reversal Research” »

At Inman Connect San Francisco, Dr. Aubrey de Grey, the chief science officer at SENS Research Foundation, talked about disrupting death.

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A universal therapy that targets mis-folded proteins is a very significant step forward if clinical trials in humans translate from animals. Obviously there is more work to be done but it this is the kind of technology we need in order to intervene against biological aging.

It is not hard to see that a therapy like this followed up by another that regenerates the brain eg, the Conboy Lab work by promoting neurogenesis could be a way to repair and restore the brain to healthy function.

A drug that breaks up different types of brain plaque shows promising results in animals and could prevent Alzheimer’s and Parkinson’s disease.

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The decline of the thymus, responsible for the upkeep of our adaptive immune system, might be due to oxidative damage and insufficient antioxidant mechanisms to combat it.

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What if “life in prison” could mean 100 or 200 or 400 years? Does that change the way that sentences are doled out? What happens when a person gets out of prison?

For all of you who’ve written in asking me to do an episode about longevity, this episode is for you. But instead of looking at the usual living forever stuff, we’re specifically going to talk about what happens when it gets applied to the prison system.

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