Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: life extension – Page 596

Journal Club July 28th 13:00 EST/18:00 UK

Join us Live on 28th July on our Facebook Page and lets talk some science. Dr. Oliver Medvedik hosts our monthly Journal Club and this time we are talking about a new protein destroying missle system that could target undruggable diseases developed at Dundee University, UK.

Journal Club is a monthly live event and runs thanks to the support of our patrons. You can become a patron here: https://www.lifespan.io/campaigns/join-us-become-a-lifespan-hero/

We are holding our third Journal Club live stream event on July 28th at 13:00 EST/18:00 UK. Dr. Oliver Medvedik live from Cooper Union NYC and the Ocean level Patrons will be discussing a recent research paper with the opportunity for viewers to join the chat, comment and ask questions.

The paper we will be discussing is the recent AdPROM study where researchers from Dundee University, UK, created a missile system capable of targeting and destroying proteins within the cell, this opens up the door for treating undruggable diseases and tackling some of the aging processes. We discuss the research here in an article.

Fulcher, L. J., Hutchinson, L. D., Macartney, T. J., Turnbull, C., & Sapkota, G. P. (2017). Targeting endogenous proteins for degradation through the affinity-directed protein missile system. Open Biology, 7, 170066.

Read more

New Cancer Vaccine Shows Promising Results in Human Clinical Trial

Customized cancer vaccines that match the unique genetic makeup of individual tumors have just passed phase 1 trials.

Cancer is predominantly a disease of aging caused by genomic instability. Finding effective ways to prevent and treat cancer is therefore of great interest to those working in the field of aging research as well as those working in oncology.

Therapies that target combinations of neoantigens, distinctive markers on the surface of cancer cells that the immune system learns to identify, is one potential approach to treating cancer. These neoantigen combinations vary between one patient and another and this is the focus of a new study which we will talk about today[1].

Immunotherapy is an approach to cancer treatment that seeks to make the immune system better at detecting and destroying cancer. This has the advantage over traditional drugs in that there should be fewer side-effects from using the body’s own defences to fight cancer.

Read more

Zoltan Istvan: the poster boy for immortality

I’m really excited to announce a 5-page feature spread on my #transhumanism work and Libertarian Governor campaign in today’s Times of London Magazine, one of England’s oldest and largest papers. There’s a paywall for digital but I think you can get two articles free without registering. If you have access to the print, it’s in the magazine:

Zoltan Istvan is launching his campaign to become Libertarian governor of California with two signature policies. First, he’ll eliminate poverty with a universal basic income that will guarantee $5,000 (£3,800) per month for every Californian household for ever. (He’ll do this without raising taxes a dime, he promises.) The next item in his in-tray is eliminating death. He intends to divert trillions of dollars into life-extending technologies – robotic hearts, artificial exoskeletons, genetic editing, bionic limbs and so on – in the hope that each Californian man, woman and AI (artificial intelligence) will eventually be able to upload their consciousness to the Cloud and experience digital eternity.

“What we can experience as a human being is going to be dramatically different within two decades,” he…

Read more

Aubrey’s trump cards

Aubrey de Grey’s famous ‘general answers’ to all concerns about rejuvenation.

Biogerontologist Aubrey de Grey, the father of SENS, always likes to answer to all objections to/concerns about rejuvenation with two general arguments. I think it is actually worth taking the trouble to answer each objection separately (which I did), but Aubrey’s answers are very good as well. I will discuss them here and add my own considerations. (If you’re interested in Aubrey’s pure thoughts, unpolluted by mine, you might want to try this short book.)

Read more

Elliott Small – AgeMeter The Functional Aging Biomarker System

Chronological age has been typically used as a way to gauge how someone is aging, however this is a poor measure indeed. People tend to age at different rates due to a variety of reasons, environment, diet, diseases in earlier life, stress, exercise and lifestyle all play a role in how a person ages.

Clearly a better way to measure aging is needed if we are to accurately assess how someone is aging for the purposes of health monitoring and research. One way to do this is to use functional aging as a way to determine how someone is aging.

Functional aging is defined as a combination of the chronological, physiological, mental, and emotional ages of a person that give an overall measure of their rate of aging.

Read more

A Son’s Race to Give His Dying Father Artificial Immortality

So I am anxious to explain the idea to my parents. The purpose of the Dadbot, I tell them, would simply be to share my father’s life story in a dynamic way. Given the limits of current technology and my own inexperience as a programmer, the bot will never be more than a shadow of my real dad. That said, I would want the bot to communicate in his distinctive manner and convey at least some sense of his personality. “What do you think?” I ask.

For months, he recorded his dying father’s life story. Then he used it to re-create his dad as an AI.

Read more

AgeMeter: Physiological Biomarkers to Determine Functional Age

Today Lifespan.io / Life Extension Advocacy Foundation has launched the fifth research project since we began 1.5 years ago. We are working with the Centers for Age Control Inc who plan to develop a multiple aging biomarker system to aid clinical research, healthcare providers and enthusiasts.

For more details check out the press release here: http://www.leafscience.org/introducing-agemeter/

Developing a diagnostic system to measure human functional age in comparison to chronological age, and assist in the assessment of anti-aging therapeutics.

Read more

Altering Microglia Types to Combat Degenerative Eye Diseases

Tweaking the types of microglia to favour a healing type over an inflammatory type has been the focus of a number of recent studies. This time the tremedous regenerative ability of zebrafish is the focus of research.

The evidence that the immune system, and in particular the various types of tissue resident macrophages play an important role in the regeneration of tissue continues to mount up.

The difference in the behaviour of these macrophages varies between species and may significantly contribute to the differences in regenerative capacity observed between slow regenerative species like mice and humans and species capable of robust rejuvenation such as salamanders and zebrafish. The latter two species being able to regenerate lost limbs and organs and the former two being far more limited.

There has been considerable interest recently in adjusting macrophage populations and types in order to encourage healing which we have talked about in articles here, here and here. Today we are going to have a look at some related research again dealing with altering types of tissue resident macrophages.

Read more

Scientists reverse ageing in mammals and predict human trials within 10 years

Salk Institute. 4 genes.

A n end to grey hair and crows-feet could be just 10 years away after scientists showed it is possible to reverse ageing in animals.

Using a new technique which takes adult cells back to their embryonic form, US researchers at the Salk Institute in California, showed it was possible to reverse ageing in mice, allowing the animals to not only look younger, but live for 30 per cent longer.

The technique involves stimulating four genes which are particularly active during development in the womb. It was also found to work to turn the clock back on human skin cells in the lab, making them look and behave younger.

Read more