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Category: life extension – Page 593

This is, in my opinion, the real point of rebutting objections to rejuvenation.

If you’ve hung around here long enough, you probably know I have two pet peeves: ageing and money. If we assume the saying ‘Only two things are certain in life: death and taxes’ is true, then we’re forced to conclude that I advocate for the (indirect) elimination of the only two certainties in life. So, if you came here looking for certainties, I’m afraid you’re in the wrong place.

I’m (mostly) not joking. Lately I’ve been working a lot on the Answers to objections section, which together with a few discussions I’ve had on the Internet, got me thinking about the point of rebutting objections to rejuvenation. Generally, when I discuss the subject with somebody who’s not at all sold on the idea of rejuvenating people, I get the feeling they expect me to prove beyond doubt that nothing can possibly go wrong, either along the way between here and an ageless world or once that world has been reached. If my feeling is correct, opposers to rejuvenation may expect that my rebuttals are meant to prove that neither a post-ageing world, nor the journey to it, will present any problems or challenges.

This expectation is utterly unrealistic. It’s actually worse than that—it’s completely wrong. There’s no way in hell I (or anyone else) could guarantee that we won’t have a dictator ruling a nation for six centuries, or that environmental problems won’t be exacerbated, etc. The reason I can’t promise none of the above will happen is the very same reason why rejuvenation opposers can’t promise any of the above will happen: Nobody can actually predict the future.

Continue reading “The point of rebutting objections to rejuvenation” | >

Why is it so hard to convince people living longer is a good thing? This short article has some evidence worth considering.

Most advocates of life extension report facing resistance to the idea of increased lifespans by medical means when trying to disseminate this idea among general public. Resistance manifests itself in many forms, ranging from concerns such as overpopulation to concerns about unequal access to life extending treatments. But the most unexpected thing is probably that people often don’t want an increased lifespan at all. Surveys in different countries show, that when people are asked “how long would you like to live?”, they often give a number equal to or slightly higher than the current life expectancy in a given country[1–4].

But wait… Isn’t extending life for more decades a good thing that everyone should strive for? In reality we often do not see enough enthusiasm for the idea in general. So why is this?

It’s not what you say, it’s how you say it

Continue reading “Intrinsic resistance to the idea of life extension or wrong messaging?” | >

Microbial burden is a real problem in aging and researchers are finding ways to boost our immune system to resist these microscopic enemies.

Microbial burden is a significant contribution to aging and our bodies are under daily attack from these microscopic invaders. The more completely we can remove these invaders the less impact they will have on the aging process.

“Researchers at the University of Illinois at Urbana-Champaign and Newcastle University in the U.K. are investigating how infectious microbes can survive attacks by the body’s immune system. By better understanding the bacteria’s defenses, new strategies can be developed to cure infections that are currently resistant to treatments, the researchers said”

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“His body, along with the others, will remain frozen indefinitely, with enough ongoing financial support to sustain its current state, news.com.au reported.

Last year, a Massachusetts Institute of Technology graduate successfully froze and reanimated a rabbit brain”.

Since his death, James Bedford’s body has been cryogenically frozen and awaiting reanimation on the edge of the Sonaran Desert in Arizona. This week marks the 50th year of Bedford’s deep freeze, making him the oldest “de-animated” human being on earth.

Bedford’s body is stored in the Alcor Life Extensions Foundation in Scottsdale, where it’s kept alongside 146 other frozen bodies, news.com.au reported.

Continue reading “After 50 years, frozen WWI veteran’s body awaits reanimation” | >

A quick look at synthetic biology and its potential for health and treating age-related diseases.

All living organisms contain an instruction set that determines what they look like and what they do. These instructions are encoded in the organism’s DNA within every cell, this is an organism’s genetic code (or “genome”).

Mankind has been altering the genetic code of plants and animals for thousands of years, by selectively breeding individuals with desired features. Over time we have become experts at viewing and manipulating this code, and we can now take genetic information associated with the desired features from one organism, and add it into another one. This is the basis of genetic engineering, which has allowed us to speed up the process of developing new breeds of plants and animals.

More recent advances however have enabled scientists to create new sequences of DNA from scratch. By combining these advances in biology with modern engineering, chemistry and computer science, researchers can now design and construct new organisms with cells that perform new useful functions. This “customised” cell biology is the essence of synthetic biology.

Continue reading “Will synthetic biology help us to eliminate age-related diseases?” | >

Some exciting news from Lifespan.io about their current senescent cell therapy campaign.

While the CellAge campaign has done a great job thus far, with over 200 backers raising $11,000+ to better target dysfunctional “senescent” cells in the body, many supporters have let us know that the holidays, along with other concurrent fundraisers, have made it challenging to contribute.

In response we have decided to announce a 1-month extension for the CellAge campaign, and give the generous members of our community greater opportunity to support this important research.

If you are unfamiliar with the project: CellAge is developing tools to better target and remove harmful senescent cells that accumulate in the body with age and play a role in various diseases such as heart disease, cancer, and osteoarthritis, and which also complicate recovery after certain treatments like chemotherapy. Having the ability to selectively remove these cells is a critical component in the fight against age-related diseases and an important tool towards lifespans that are both long and healthy.

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It seems more likely what you remove is more important than what you add with old blood.

The evidence is increasingly suggesting that dilution of pro-aging signals is why we are seeing rejuvenation when blood is exchanged between young and old animals. Forget transfusions the next step is to filter our own blood to promote health as we age.

#aging #crowdfundthecure

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We are at the cusp of a stem cell revolution.

Understanding and harnessing these unique cells may unlock breakthroughs in longevity and therapeutic solutions to all kinds of chronic diseases and regenerative opportunities.

Last month, I took a trip down to the Stem Cell Institute in Panama City with Dr. Bob Hariri (co-Founder of Human Longevity Inc.) to get stem cell injections in my knee and shoulder as an alternative to reconstructive surgery.

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Exercise is one of the best ways to slow down aging and its free too!

(Boston) — Older adults who experience good cardiac fitness may be also keeping their brains in good shape as well.

In what is believed to be the first study of its kind, older adults who scored high on cardiorespiratory fitness (CRF) tests performed better on memory tasks than those who had low CRF. Further, the more fit older adults were, the more active their brain was during learning. These findings appear in the journal Cortex. Difficulty remembering new information represents one of the most common complaints in aging and decreased memory performance is one of the hallmark impairments in Alzheimer’s disease.

Healthy young (18−31 years) and older adults (55−74 years) with a wide range of fitness levels walked and jogged on a treadmill while researchers assessed their cardiorespiratory fitness by measuring the ratio of inhaled and exhaled oxygen and carbon dioxide. These participants also underwent MRI scans which collected images of their brain while they learned and remembered names that were associated with pictures of unfamiliar faces.

Continue reading “Older, fitter adults experience greater brain activity while learning” | >

(Phys.org) —Tufts University biologists using new, automated training and testing techniques have found that planarian flatworms store memory outside their brains and, if their heads are removed, can apparently imprint these memories on their new brains during regeneration.

The work, published online in the Journal of Experimental Biology, can help unlock the secrets of how memories can be encoded in living tissues, noted Michael Levin, Ph.D., Vannevar Bush professor of biology at Tufts and senior author on the paper.

“As and biomedicine advance, there’s a great need to better understand the dynamics of memory and the brain-body interface. For example, what will happen to stored memory if we replace big portions of aging brains with the progeny of fresh ?” said Levin, who directs the Center for Regenerative and Developmental Biology in Tufts’ School of Arts and Sciences.

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