Lifeboat Foundation

An interview with Dr. Vadim Gladyshev, Harvard University.

We have recently had occasion to have a chat with Dr. Vadim Gladyshev, Professor of Medicine and Director of Redox Medicine at Brigham and Women’s Hospital, Harvard Medical School, in Boston, Massachusetts. He is an expert in aging and redox biology and is known for his characterization of the human selenoproteome. His research laboratory focuses on comparative genomics, selenoproteins, redox biology, and, naturally, aging and lifespan control.

Dr. Gladyshev graduated from Moscow State University, in Moscow, Russia; his postdoctoral studies in the 1990s took place at the National Heart, Lung, and Blood Institute, and the National Cancer Institute, in Bethesda, Maryland. Even when he was young, he was very much interested in chemistry and experimental science: he twice won the regional Olympiad in chemistry and graduated from high school with a gold medal. He also graduated with the highest honors from Moscow State University. This enviable track record is even more impressive considering that Dr. Gladyshev completed music school and high school at the same time and became a chess player equivalent to national master during his college years.

Continue reading “Dr. Vadim Gladyshev – Harvard University” »

At least in the developed world, cancer, heart diseases, and neurodegenerative diseases are among the greatest causes of mortality. One emerging and very promising way to prevent or cure these diseases is through bio-nanotechnology.

Nanotechnology is the design, synthesis and application of materials or devices that are on the nanometer scale (one billionth of a meter). Due to the small scale of these devices, they can have many beneficial applications, both in industry and medicine. The use of nanodevices in medicine is called nanomedicine. Here, we will look at some applications of nanomedicine in curing or preventing the diseases that are most likely to kill us.

Today we will be taking a look at some of the stories people tell themselves to help them pretend aging is not a problem.

If you ask most people what they think about aging, they will shrug their shoulders and say that it is a natural process. With complete tranquility on their faces, they will agree that, yes, in old age, we are haunted by many diseases, but nothing can be done about it, so it makes no sense to worry about it while you are young and healthy. Just live your life.

Then, the conversation will turn towards an even stranger direction: they will start looking for something good about aging – for example, that it ensures a change of generations, prevents society from becoming stuck in obsolete ideas, and, in general, is the engine of evolution. They’ll explain that the notion of death gives meaning to life and makes us accomplish as much as possible in the little time we have.

Continue reading “Is aging not scary? The children’s tales that are killing us” »

It seems reasonable that people would want to maximize various aspects of life if they were given the opportunity to do so, whether it’s the pleasure they feel, how intelligent they are, or how much personal freedom they have. In actuality, people around the world seem to aspire for more moderate levels of these and other traits, according to findings published in Psychological Science, a journal of the Association for Psychological Science.

“Our research shows that people’s sense of perfection is surprisingly modest,” says psychological scientist Matthew J. Hornsey of the University of Queensland, first author on the research. “People wanted to have positive qualities, such as health and happiness, but not to the exclusion of other darker experiences—they wanted about 75% of a good thing.”

Furthermore, people said, on average, that they ideally wanted to live until they were 90 years old, which is only slightly higher than the current average life expectancy. Even when participants imagined that they could take a magic pill guaranteeing eternal youth, their ideal life expectancy increased by only a few decades, to a median of 120 years old. And when people were invited to choose their ideal IQ, the median score was about 130—a score that would classify someone as smart, but not a genius.

Continue reading “Around the world, people have surprisingly modest notions of the ‘ideal’ life” »

Glorious news! Undoing Aging 2019 has been announced today hosted by Forever Healthy and the SENS Research Foundation. We loved being there last year and bringing the community all the news and interviews from the event and we are delighted to see it is making a return in 2019.

We are very pleased to see that there will be a return of the successful Undoing Aging Conference in 2019. We attended the conference earlier this year, and as we reported at the time, it was a really positive experience.

This was, from the outset, a serious conference focused on the rapid science and research going on in the field and was just the kind of conference that the community needed. The conference was a superb mixture of respected researchers, investors, and thought leaders from the community, and it had no hint of the snake oil that has plagued our community in past years.

Continue reading “Undoing Aging 2019 is Confirmed” »

Exciting news smile

Mountain view, california / berlin, germany.

After the incredible success of the 2018 Undoing Aging Conference with 350 participants from 36 countries and over 40 brilliant speakers, SENS Research Foundation (SRF) and Forever Healthy Foundation (FHF) are pleased to announce that Undoing Aging 2019 will take place in Berlin at the Umspannwerk Alexanderplatz from March, 28 to 30.

Continue reading “The 2019 Undoing Aging Conference will take place March 28 — 30 in Berlin, Germany” »

Glossing over the fact ageing is a chronic decline in function won’t help with anything, let alone ending ageism.

At times, I think that I have written enough rejuvenation advocacy articles and that every time I write a new one, I’m just repeating myself. I sometimes say to myself that I’ve written about concerns and misconceptions from so many angles that I’ve probably exhausted all the options. However, from time to time, there comes the bittersweet reassurance that I’m not going to be out of a job any time soon.

The culprit

Continue reading “Sugarcoating aging won’t fight ageism” »

Investigators at Harvard Medical School have identified the key cellular mechanisms behind vascular aging and its effects on muscle health, and they have successfully reversed the process in animals.

The scientists used a chemical compound that’s an NAD+ booster called NMN which plays a critical role in repairing cellular DNA as well as maintaining cell vitality to test what would happen.

Could reversing the aging of blood vessels hold the key to restoring youthful vitality? If the old adage “you are as old as your arteries” reigns true then the answer is yes, at least in mice.

Continue reading “Harvard Rewinds the Biological Clock of Time” »

Today, we want to draw your attention to an open-access review that focuses on the role of senescent cells in sarcopenia, the age-related loss of muscle mass and strength that leads to frailty.