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Archive for the ‘life extension’ category: Page 462

Jul 4, 2018

Manipulating the Immune System for Cancer Immunotherapy

Posted by in categories: biotech/medical, life extension

Researchers have manipulated the immune system to respond more aggressively to cancer according to a new study [1].

Manipulating macrophages

We have discussed modulating the immune system multiple times recently, especially in regards to macrophages and manipulating their behavior. Macrophages are part of the innate immune system and carry out a wide variety of tasks, such as clearing away cell debris, engulfing pathogens, facilitating tissue growth, and disposing of senescent cells once other immune cells have destroyed them.

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Jul 4, 2018

Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity

Posted by in categories: genetics, life extension

Life extension genetics.


Many factors contribute to exceptional longevity, with genetics playing a significant role. However, to date, genetic studies examining exceptional longevity have been inconclusive. This comprehensive review seeks to determine the genetic variants associated with exceptional longevity by undertaking meta-analyses.

Meta-analyses of genetic polymorphisms previously associated with exceptional longevity (85+) were undertaken. For each variant, meta-analyses were performed if there were data from at least three independent studies available, including two unpublished additional cohorts.

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Jul 3, 2018

Human stem cells give monkey hearts a boost after heart attacks, study says

Posted by in categories: biotech/medical, life extension

Following heart attacks, a handful of monkeys regained some of the pumping ability their hearts had lost after being given human embryonic stem cells, according to a study published Monday in Nature Biotechnology.

Scientists have tried for years to develop a stem cell treatment for heart disease caused by lack of blood flow, which contributed to more than 9.4 million deaths worldwide in 2016, according to the World Health Organization.

“We’re talking about the number one cause of death in the world [for humans],” said study author Dr. Charles Murry, director of the Institute for Stem Cell and Regenerative Medicine at the University of Washington. “And at the moment all of our treatments are … dancing around the root problem, which is that you don’t have enough muscle cells.”

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Jul 3, 2018

Too healthy for your own good?

Posted by in categories: business, life extension

Why on Earth would you ever want to be less than completely healthy?


Recently, Reason of Fight Aging! pointed out psychological research revealing a certain conservatism in terms of what people consider to be the “ideal” levels of happiness, intelligence, longevity, and even health.

It probably doesn’t come as a surprise that significant numbers of people in the studies weren’t too keen on the idea of living much longer than the average (around 90 years), and even under the assumption of eternal youth, their preference didn’t go past 120 on average; after all, LEAF wouldn’t be in business if the idea of healthy life extension wasn’t so inexplicably frowned upon. What’s really flabbergasting, though, is that even health—health!—is apparently something you can have too much of; on a scale from 0 (“completely unhealthy”) to 100 (“completely healthy”), the average preference gravitated somewhere between 80 and 90. These results provide us with an occasion for reflection.

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Jul 2, 2018

Are There Potentially Better Long-term Solutions to Senescent Cells than Senolytics?

Posted by in categories: biotech/medical, life extension

Senolytics have been in the news a great deal ever since van Deursen and his team conducted a landmark 2011 study showing that removing senescent cells could delay age-related ill health in mice [1]. Since then, interest in what was once a niche topic has continued to grow at an ever-increasing pace. Now, there are many researchers engaged in exploring senescent cells and their role in aging and disease.

Lately, there has been enthusiastic interest in developing therapies to remove these problematic senescent cells, but are there potentially better ways to deal with senescent cells beyond periodically purging them with senolytic drugs and therapies?

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Jul 2, 2018

Rejuvenation Roundup June 2018

Posted by in categories: biotech/medical, life extension

LEAF’s monthly rejuvenation roundup is out!


July is here, and our upcoming conference in New York City is only a handful of days away! If you haven’t done so already, go and get your ticket now so that you can enjoy the June roundup fully relaxed, knowing that your seat is secured.

About our NYC conference

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Jul 2, 2018

Once you hit this age, aging appears to stop

Posted by in category: life extension

Data from Italian centenarians suggests a “mortality plateau”.

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Jul 1, 2018

Google sister company and drug giant chip in another $1 billion to cure age-related diseases

Posted by in categories: biotech/medical, computing, life extension

Google sister company Calico and drug giant AbbVie are chipping in another $1 billion to cure diseases associated with aging, the companies said Tuesday.

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Jun 29, 2018

The First Rejuvenation Therapy Reaches Human Trials

Posted by in categories: biotech/medical, life extension

Senolytics developed by UNITY Biotechnology are currently in Phase-1 clinical trials.


Today we are pleased to announce that UNITY Biotechnology is going into human clinical trials with the first true rejuvenation therapy that directly targets one of the processes of aging: senescent cells.

The quiet revolution

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Jun 29, 2018

Why Older People Are Using the Blood of Teenagers to Live Longer

Posted by in categories: biotech/medical, food, life extension

The secret of life extension from vampires.


Getting older and dying is so inconvenient. Eating a healthy diet and exercising is a good start in warding off death, but if you’re looking to truly up your immortality game, the answer is simple: teen blood. For a whopping $8,000, the old and the wealthy can receive a blood transfusion from a teenager. Yes, you read that right.

At Ambrosia’s clinics in San Francisco and Tampa, Florida, the wrinkled are receiving what founder Dr. Jesse Karmazin simply refers to as a “young blood treatment.” Patients are administered a transfusion of around 0.66 gallons of blood acquired from donors between the ages of 16 and 25.

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