We recently visited the Longevity Leaders Conference in London and had the opportunity to speak with Kelsey Moody, the CEO of Ichor Therapeutics, a company focused on targeting age-related diseases by targeting the aging processes themselves. We previously interviewed him back in 2017, so it was the ideal time to catch up on what had been happening with his company since then.
Ichor and its portfolio companies have been very busy over the last year, so I thought it was time that we caught up on progress. Can you tell us how things are going for the Ichor group?
Ichor really had a good year in 2018. We raised over $16 million across our portfolio, and that’s really allowed us to scale up all aspects of our operations. We’re at over 50 employees now, mostly bench scientists and research technicians, and we’re really delivering on our goal of being a vertically integrated biopharmaceutical company.
New research, which has been published today in the EMBO Journal, could suggest a new way of preventing heart failure in older patients.
Heart failure occurs when the heart is not pumping blood around the body as well as it should, most commonly when the heart muscle has been damaged – for example, after a heart attack.
Researchers at Newcastle University have shown that clearing out senescent cardiac muscle cells from the hearts of aged mice restores heart health.
It seems that not a month goes by without a new study showing that senolytics, drugs that remove aged and damaged cells from the body, improve organ or tissue function by reversing some aspects of aging. A new study has shown that removing senescent cells from the hearts of old mice restores heart health and alleviates the detrimental effects of cardiac aging, including myocardial hypertrophy and fibrosis.
Today, we conclude our ongoing series discussing the Hallmarks of Aging [1] by looking at the hallmark of altered intercellular communication, the change in signals between cells that can lead to some of the diseases and disabilities of aging.
As an integrative hallmark, altered intercellular communication is caused by other hallmarks of aging. As a result, there is some hope that therapies targeting these other hallmarks will be able to treat this one.
There are a wide range of complex intercellular communications associated with aging, but we will focus on the ones discussed in the Hallmarks of Aging paper.
“If you’re under 40 reading this article, you’re probably not going to die unless you get a nasty disease.”
Those are the words of esteemed futurologist Dr. Ian Pearson, who told The Sun he believes humans are very close to achieving “immortality” – the ability to never die.
Humans have been trying to find a way to dodge death for years.
The Book of Gates
Posted in life extension, robotics/AI, space
God” according to Rev Benek is working thru people like me who are pioneers in the AI and uploading field — and I am developing a Zenet interface for artificial death simulating the Khemetic afterlife — not a Judeo-Christian version. Osiris is a key deity in Zenet, and has a special place in Mormonism btw. There are good technical reasons for using Zenet. Objectives for the dead are slightly different than play strategy for the living in Zenet (having already passed over the dangerous waters). It is the Bridge between Worlds perfect for artificial-death, no biblical or koranic account exists how to communicate between living and deceased. “The betterment of mankind” imo involves the Restoration of Ma’at. And the Egyptian afterlife is available to all races (not just chosen people) — “Hour Five is one of the most complex hours within the composition. In the upper registers, the gods are portrayed with a surveying cord, because the deceased are allotted space (in the form of fields) within this hour. The deceased are also allotted time, and hence the gods also carry the body of a serpent and the hieroglyphs meaning “lifetime” in the lower register. In order to accomplish this, the Apophis fiend, known as “the Retreater, must once again be battled and fettered. Behind Apophis we notice the ba-souls of the blessed dead, and at the beginning of the lower register are found the four ”races” of mankind, including Egyptians, Asiatics, Nubians and Libyans. Each race is represented by four individual figures, who are assured existence in the afterlife. They are placed in the care of Horus and Sakhmet. It should be noted that the Great Hymn of Akhenaten, Aten is said to care even for foreign people, and hence, they are sheltered in the realm of the dead, according to Even if the uploading doesn’t take, this belt and braces offering still offers (conventional religious) Immortality with Horus, Amen, Isis, Thoth and the gang. Why does it matter which ”God(s)” — so long as we make it to the (1st) afterlife with the bonus of communication with the living?
Funerary Text from Egypt’s New Kingdom.
Researchers have made progress on the road to effective biomarkers for senescent cells.
In aging research, there has long been a need for better biomarkers that can detect and confirm the presence of senescent cells. This has become particularly urgent in recent years due to the meteoric rise of the senescent cell-clearing therapies known as senolytics.
Traditional ways of measuring senescent cell populations are problematic and have multiple shortfalls, so the development of better biomarkers is very important. Today, we share a new publication in which researchers take a step towards developing such a biomarker [1].
Abstract