Lifeboat Foundation: Safeguarding Humanity
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Category: life extension – Page 455

In November, Dr. Aubrey de Grey, a graduate of the University of Cambridge, was in Spain to attend the Longevity World Forum in the city of Valencia, and he gave a press conference organized by his friend, MIT engineer José Luis Cordeiro.

Dr. Aubrey de Grey is the scientific director (CSO) and founder of the SENS Research Foundation. In Madrid and Valencia, Dr. de Grey reaffirmed for Tendencias21 one of his most striking statements of 2018: “In the future, there will be many different medicines to reverse aging. In five years, we will have many of them working in early clinical trials.”

The Longevity World Forum is a congress on longevity and genomics in Europe. It is heir to the first congress in Spain, the International Longevity and Cryopreservation Summit, which was held at the CSIC headquarters in Madrid in May 2017, and Dr. de Grey also participated in that event. In Valencia, his presentation was recieved with interest, and Dr. de Grey explained to this select audience that aging will be treated as a medical problem in the near future. Rather than treating its symptoms using the infectious disease model, the root causes of aging will themselves be treated.

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How would you like to take one injection that has multiple genes that improve cellular repair and regeneration, keeping your cells younger and healthier longer? Today, BioViva and Rutgers University are embarking on an ambitious research project to do just that; we are tackling humanities greatest foe — suffering and death due to aging.

Read the press release here:

https://www.eurekalert.org/pub_releases/2018-12/bui-rua121018.php

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Today, we present an interview with Reason, the editor of Fight Aging! and co-founder of Repair Biotechnologies. We asked him about the state of rejuvenative therapies, some of which may be available in the near future.

Fight Aging! was the first blog that tackled the science of aging in a serious fashion. Many people still treat it as the go-to site for high-quality information and opinion on the rapidly growing field of biogerontology.

Reason (he goes by only his first name), the brain behind the Fight Aging! blog, has been involved in one way or another with anti-aging science for almost two decades as a writer, researcher, and investor. His new company, Repair Biotechnologies, is focused mainly on halting thymic atrophy and atherosclerosis, which causes about 20 percent of all human deaths.

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“Manuel has been a world-leading researcher in cell senescence for decades, and participated in various of our conferences starting many years ago. His latest breakthrough, which he will discuss in Berlin, is one of those head-slappingly brilliant concepts that I encounter at most once per year, combining a couple of long-established ideas in a completely novel way that potentially delivers far more than the sum of the parts. I won’t spoil the surprise here!” says Aubrey de Grey.

https://www.undoing-aging.org/news/dr-manuel-serrano-to-spea…aging-2019

#undoingaging #sens #foreverhealthy

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Mild cognitive impairment (MCI) is an intermediate stage between the expected cognitive decline of normal aging and the more-serious decline of dementia. It can involve problems with memory, language, thinking, and judgment that are greater than normal age-related changes.

If you have mild cognitive impairment, you may be aware that your memory or mental function has “slipped.” Your family and close friends also may notice a change. But generally these changes aren’t severe enough to significantly interfere with your day-to-day life and usual activities.

Mild cognitive impairment may increase your risk of later progressing to dementia, caused by Alzheimer’s disease or other neurological conditions. But some people with mild cognitive impairment never get worse, and a few eventually get better.

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A number of therapies that directly target the aging processes are currently in human trials and could change medicine significantly in the next decade if the results are positive.

What is aging?

Aging is basically the accumulation of damage and errors caused by a collection of varied processes that harm the functions of the body through the accumulation of waste, imperfect repair, the deregulation of cellular processes, the dysfunction of the immune system, chronic inflammation, and other disorders.

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Today, we want to discuss this review published in the journal Science, as it provides a whistle-stop tour of caloric restriction, intermittent fasting, and time-restricted feeding.

There is a considerable amount of data supporting the effects of caloric restriction and similar dietary approaches on both health and lifespan in multiple species. In general, the more simple the organism, the greater the observed effect tends to be, although the effect is less so in longer-lived organisms. For example, caloric restriction has a significant effect on mouse lifespan, but it appears to do little, if anything, to the lifespan of humans.

Why is this? One explanation could be that, as humans, we have already evolved efficient repair systems that more thoroughly address the damages of aging than the repair systems of mice and other short-lived species. In other words, there is little improvement to be made to human repair systems compared to those of mice.

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