Lifeboat Foundation

The global population aged 60 or over is growing faster than all younger age groups and faces the tide of chronic diseases threatening their quality of life and posing challenges to healthcare and economy systems. To better understand the underlying biology behind healthspan — the healthy period of life before the first chronic disease manifestation — the scientists from Gero and MIPT collaborated with the researchers from PolyOmica, the University of Edinburgh and other institutes to analyze genetic data and medical histories of over 300,000 people aged 37 to 73 made available by UK Biobank.

The study published today in Communications Biology was lead by Dr. Peter Fedichev and Prof. Yurii Aulchenko. It shows that the most prevalent chronic conditions such as cancer, diabetes, chronic obstructive pulmonary disease, stroke, dementia, and some others apparently share the common underlying mechanism that is aging itself.

«According to Gompertz mortality law, the risk of death from all causes increases exponentially after the age of 40 and doubles approximately every 8 years», explains Peter Fedichev, founder and CSO of Gero. «By analyzing the dynamics of disease incidence in the clinical data available from UKB, we observed that the risks of age-related diseases grow exponentially with age and double at a rate compatible with the Gompertz mortality law. This close relation between the most prevalent chronic diseases and mortality suggests that their risks could be driven by the same process, that is aging. This is why healthspan can be used as a natural proxy for investigation of the genetic factors controlling the rate of aging, the “holy grail” target for anti-aging interventions».

Last month, researchers at Johan Auwerx’s lab at the Ecole Polytechnique Fédérale de Lausanne (EPFL) had looked at the connections between RNA-binding proteins and aging. RNA binding proteins (RBPs) play an important part in post-transcriptional control by binding to mRNAfter binding, RBPs can aid in the processing of pre-mRNA as well as mRNA stability, transport and translation [1].

Mitochondria

Upon screening aged animals for RBPs, researchers at the EPFL noticed increased activity of Pumilio2 (PUM2), which can lower the production of some proteins. It does this by binding to specific mRNAs (based on recognition sites) so that it can repress the translation of those mRNAs into proteins.

Longevity Vision Fund has exited stealth with plans to invest $100 million in startups with aspirations to extend healthy lifespans. The fund, which is linked to the founder of XPrize, will pump the money into biotechs and other longevity startups based around the world in seed to series B rounds.

Sergey Young, the founder of Longevity Vision, unveiled the fund at an event in London this week. Young is the cofounder of Peak State Ventures and an innovation board member at XPrize Foundation, a nonprofit known for running competitions to incentivize advances in fields including suborbital space flight.

At Peak State, Young and his colleagues invest in fields well outside of longevity, including property and education. But Young has established a foothold in the longevity space, leading to him becoming development sponsor of Longevity XPrize and a longevity partner at Bold Capital Partners.

Continue reading “XPrize board member raises $100M fund to tackle aging” »

Combining Machine Learning and Your Gut

The link between the gut biome and age is described by longevity researcher Alex Zhavoronkov and a team of his colleagues at Insilico Medicine, an artificial intelligence startup focused on drug discovery, biomarker development, and aging research.

Project fear? Should we pay attention to American Jesuits?

But the fundamental ambition of transhumanism is more problematic. Its architects champion a use of technology to accelerate the evolution of humanity so radically that at the end of the process humanity as such would disappear. A superior posthuman being would emerge. According to Wikipedia, “Transhumanism is the intellectual and cultural movement that affirms the possibility and desirability of fundamentally improving the human condition through applied reason, especially by developing and making widely available knowledge to eliminate aging and to greatly enhance human intellectual, physical, and psychological capacities.” From its inception, the abolition of human death and aging has been one of the goals of transhumanism as it engineers a new being freed from the biological constraints of the current human condition.

From its inception, the abolition of human death and aging has been one of the goals of transhumanism.

Continue reading “Who’s afraid of transhumanism? (We all should be)” »

February 4th, 2019 saw the Longevity Leaders Conference hosted in Aldersgate, London. I was fortunate enough to have been invited to attend this interesting event, so I thought that today was the ideal time to share some experiences of the conference with you.

The conference was quite broad in scope and included people from the aging research community, the pharmaceutical industry, general healthcare, and the business and insurance fields.

Very excited to have interviewed Dr. Michael Lustgarten in my role as longevity / aging ambassador for the ideaXme Show — Mike has been at the forefront of studying the 100 trillion organisms present in the human microbiome, their effect on human health and wellness, as well as a major proponent of metabolomics and biologic age tracking — A true future thinker in the area of extending human lifespan and healthspan

“Ruth is a shining example of one of the qualities I most admire in a scientist: dogged perseverance in pursuit of one’s thesis, in spite of near-universal rejection of it by the mainstream community, until one finally wins them round.

It’s only an admirable quality if you’re likely to be right, of course, so you’d better be a really good scientist in other ways too — and she sure is. Ruth spoke at a couple of my Cambridge conferences and I was always dismayed that such solid data and logic concerning the involvement of herpes simplex virus in Alzheimer’s disease was so widely ignored or dismissed for what seemed to be totally flimsy reasons. That’s not happening any more!”, says Aubrey de Grey.

https://www.undoing-aging.org/news/dr-ruth-itzhaki-to-speak-…aging-2019

Researchers develop an app that can estimate the biological age of a rodent from its mug shot, and could give a boost to the science of human aging in the process.