Yale is making waves. They have had great Research papers over the past 3 years. Some of which has proven my constant words now for two decades that we have a pandemic plague that attacks our individual Eukaryotic cells the day long causing What AEWR Has named the Senesonic plague the disease we have called aging. Respect r.p.berry & AEWR https://adamandevewordresearch.blogspot.com/

The researchers did not hail from House Greyjoy — “What is dead may never die” — but came largely from the Yale School of Medicine. They connected 32 pig brains to a system called Brain Ex. Brain Ex is an artificial perfusion system — that is, a system that takes over the functions normally regulated by the organ. Think a dialysis machine for the mind. The pigs had been killed four hours earlier at a U.S. Department of Agriculture slaughterhouse; their brains completely removed from the skulls.

Brain Ex pumped an experiment solution into the brain that essentially mimic blood flow. It brought oxygen and nutrients to the tissues, giving brain cells the resources to begin many normal functions. The cells began consuming and metabolizing sugars. The brains immune system kicked in. Neuron samples could carry an electrical signal. Some brain cells even responded to drugs.

The researchers have managed to keep some brains alive for up to 36 hours, and currently do not know if Brain Ex can have sustained the brains longer. “It is conceivable we are just preventing the inevitable, and the brain won’t be able to recover,” said Nenad Sestan, Yale neuroscientist and the lead researcher.

Science CEO Liz Parrish are in a fight to eradicate diseases of aging. Preventive & regenerative gene therapies are key to fixing cellular death.

Videos will be released step by step over the next few weeks as we receive clearance from the individual speakers.

This week we kick it off with Jerry Shay, who is the Vice Chairman of the Department of Cell Biology at The University of Texas Southwestern Medical Center in Dallas, presenting ‘Telomeres and Telomerase in Aging and Cancer‘.

undoing-aging.org/…/jerry-shay-presenting-at-undoing-aging-…

More info on Forever Healthy: forever-healthy.org

Living forever wouldn’t be good for the species. Did nature make a way to keep it from happening?

2 minute Read.

Understandably, the FDA raised concerns about the practice of parabiosis because to date, there is a marked lack of clinical data to support the treatment’s effectiveness.

Elevian

On the other end of the reputability spectrum is a startup called Elevian, spun out of Harvard University. Elevian is approaching longevity with a careful, scientifically validated strategy. (Full Disclosure: I am both an advisor to and investor in Elevian.)

A number of companies are studying and commercializing rapamycin and rapalogs, including resTORbio, a Boston-based company. Tam Hunt got in touch with Dr. Joan Mannick from the company to find out more about this promising anti-aging therapeutic.

Blagoskonny ([3], [4]) has suggested that rapamycin and rapalogs are effective anti-aging therapies today for humans as well as other animals because they arrest “quasi-programmed hypertrophy.” What are your thoughts on Blagoskonny’s theory?

I think Blagoskonny’s theory is very interesting. mTOR stimulates cell growth, and there is data that mTOR becomes hyperactive in some aging tissues. This may explain why TORC1 inhibitors have benefit in aging-related diseases.

We have known since the 19th century that young blood has surprising curative and rejuvenation abilities. It’s quite strange, but it happens to be true. In recent years, scientific efforts to understand what it is about young blood that causes rejuvenation have ramped up.

We now know that young and old mice with surgically connected circulatory systems will experience altered aging: the young mouse will prematurely grow old, and the old mouse will, in many cases, miraculously grow young. This is known as heterochronic parabiosis, and it is a large source of the legitimate excitement about the potential of young plasma to lead to human rejuvenation [1].

The challenge, of course, is how to achieve these benefits in more acceptable and less disturbing ways.

Allison Duettmann challenges Aubrey De Grey with the top objections against longevity to be debunked and debated before opening up the floor to the public.

Aubrey de Grey, Ph.D.

SENS chief science officer and co-founder.

Dr. de Grey is the biomedical gerontologist who researched the idea for and founded SENS Research Foundation. He received his BA in Computer Science and Ph.D. in Biology from the University of Cambridge in 1985 and 2000, respectively. Dr. de Grey is Editor-in-Chief of Rejuvenation Research, is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organizations.