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Category: life extension – Page 385

💰 Longevity Feature Film

Good news, everyone! We’ve been selected for a Gitcoin grant partnership to help democratize and incentivize future funding for our upcoming feature-length film’s development.

Gitcoin grants operate with crypto under a system known as “Quadratic Funding.” In other words, amounts are important, but the number of people donating also helps tremendously by boosting matching funds from a pre-established pool. So even small donation amounts can be hugely helpful. Therefore, any donation we receive from you will then be matched at an ever-increasing amount with each new donation.

We’re very excited to see where this takes us and if you’d like to contribute to the financing with more bang for your buck, check out the link below and start donating!

“The Last Generation to Die” is a cinematic quality full feature film on longevity. It’s a drama set in the future that examines the estranged relationship of two generations on the cusp of the end of aging and the ultimate merging of science and nature that will usher humanity into the next stage of evolution.

Logline: In a near future when age reversal therapies are on the cusp of becoming reality, a scientist tries to save her father from natural death.

“The Last Generation to Die” began its life as a staff-picked, 393% funded Kickstarter short film. We’re extending that life as a full feature length film. The short film was in a variety of festivals, garnering excellent reviews, and serves as a proof-of-concept for the full length feature film.

Continue reading “💰 Longevity Feature Film” | >

Forever Young — Searching for the Fountain of Youth | Clip of a CBS News Special

This is a short videoclip I made of the CBS News Special program entitled “Forever Young_Searching for the Fountain of Youth” aired on Nov 29, 2021.

The entire program lasts 43 minutes and in this 2-minute videoclip I highlight the excerpts I found most relevant. In the description of the video is the link to see the entire program.

El videoclip cuenta con subtítulos en Español.

This is a short clip I made of the CBS News Special program “Forever Young_Searching for the Fountain of Youth” aired on Nov 29, 2021.

To watch the entire program please clic here: https://www.cbsnews.com/video/sunday-morning-special-forever
-of-youth/

Continue reading “Forever Young — Searching for the Fountain of Youth | Clip of a CBS News Special” | >

Mexican Scientist Asks What Can Ants Tell Us About Human Fertility

Mexican biologist Ingrid Fetter-Pruneda is studying the longevity and fertility in ants in the hope of helping to develop strategies to avoid, slow down or reverse female reproductive aging in other animals or in humans.

Fetter-Pruneda, an Assistant Professor at the Universidad Nacional AutĂłnoma de MĂ©xico (UNAM), says most animals show a trade-off between longevity and fertility, but one of the most striking features of ants is that the queens are simultaneously very long lived and very fertile, while the workers are short lived and sterile.

“I am trying to figure out the cellular and molecular mechanisms that allow queens to remain fertile throughout their relatively long lives,” Fetter-Pruneda says, “Many molecular pathways are conserved across many species, and new discoveries in ants could help direct research in other organisms.”

DAVID SINCLAIR “One Therapy To Reverse All Hallmarks Of Aging” | Dr David Sinclair Interview Clips

Kind of starts out with a no but ends in a yes. Just a few minutes long.

An increasing number of studies suggest the presence of a “metabolic clock” that controls aging. This clock involves the accumulation of metabolic alterations and a decline in metabolic homeostasis and biological fitness. There are nine cellular hallmarks of aging: telomere attrition, genomic instability, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, loss of proteostasis, deregulated nutrient sensing, epigenetic alterations, and altered intercellular communication. Metabolic alterations have been implicated in each of these processes.

https://www.cell.com/fulltext/S0092-8674(13)00645-4
https://www.cell.com/cell/pdf/S0092-8674(16)30981-3.pdf.

David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.

Dr David Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives.

Continue reading “DAVID SINCLAIR “One Therapy To Reverse All Hallmarks Of Aging” | Dr David Sinclair Interview Clips” | >

Scientists Put a Worm Brain in a Lego Robot Body

Circa 2017

The brain is really little more than a collection of electrical signals. If we can learn to catalogue those then, in theory, you could upload someone’s mind into a computer, allowing them to live forever as a digital form of consciousness, just like in the Johnny Depp film Transcendence.

But it’s not just science fiction. Sure, scientists aren’t anywhere near close to achieving such a feat with humans (and even if they could, the ethics would be pretty fraught), but there’s few better examples than the time an international team of researchers managed to do just that with the roundworm Caenorhabditis elegans.

C. elegans is a little nematodes that have been extensively studied by scientists — we know all their genes and their nervous system has been analysed many times.

“Sunday Morning” primetime special: “Forever Young: Searching for the Fountain of Youth” (November 28)

“Sunday Morning” anchor Jane Pauley hosts “Forever Young: Searching for the Fountain of Youth,” a one-hour primetime special exploring the wonders, rewards, and challenges of growing older, to air on CBS Sunday, November 28 at 10 p.m. ET/PT, and to stream on Paramount+.

Can we reset our biological clocks? | Watch Video Life expectancy has increased in recent decades, but researchers are looking for ways to further slow the aging process. Correspondent Lee Cowan looks into recent developments in the study of extending human life, and efforts to ward off disease by targeting the biology of aging itself.

Spermidine Impacts Health and Longevity

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https://www.patreon.com/MichaelLustgartenPhD

Papers referenced in the video:
Polyamine-rich food decreases age-associated pathology and mortality in aged mice.
https://pubmed.ncbi.nlm.nih.gov/19735716/

Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats.
https://pubmed.ncbi.nlm.nih.gov/32285289/

Cardioprotection and lifespan extension by the natural polyamine spermidine.
https://pubmed.ncbi.nlm.nih.gov/27841876/

Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy.
https://pubmed.ncbi.nlm.nih.gov/28386016/

Higher spermidine intake is linked to lower mortality: a prospective population-based study.

Continue reading “Spermidine Impacts Health and Longevity” | >

NIH launches program to map a rare type of non-dividing cells implicated in human health and disease

The National Institutes of Health has launched a program to study a rare type of cells, called “senescent” cells, that play both positive and negative roles in biological processes. The NIH Common Fund’s Cellular Senescence Network (SenNet) program will leverage recent advances in studying individual cells, or single-cell analysis, to comprehensively identify and characterize the differences in senescent cells across the body, across various states of human health, and across the lifespan. The rarity and diversity of these cells previously made them difficult to identify and study; therefore, a deeper understanding will help researchers develop therapies that encourage beneficial effects of senescent cells while suppressing their tissue-damaging effects.

“The number of senescent cells in a person’s body increases with age, which may reflect both an increase in the generation of these cells and a decreased ability of the aging immune system to regulate or eliminate these cells. This age-related accumulation of senescent cells leads to production of inflammatory molecules and corruption of healthy cells,” said Richard J. Hodes, M.D., director of the National Institute on Aging, part of NIH. “This can affect a person’s ability to withstand stress or illness, recuperate from injuries, and maintain normal brain function. The aim of NIH’s strengthened focus on this field of science is to one day conquer these and other challenges.”

A cell dividing into two cells is a hallmark of human development. Over time, our bodies accumulate a small number of cells that no longer divide. These “senescent” cells can play important roles in health, either directly or through the release of molecules that affect neighboring cells. Senescent cells can play positive roles, such as aiding wound repair or preventing tumor growth in some cancers. However, they can also contribute to chronic diseases of aging such as cardiovascular disease and neurodegeneration. For this reason, therapeutics called “senolytics” are being developed to target senescent cells and remove them from the body.

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