Changes to gene activity in mice show the ageing process can be slowed or even reverse, leading to hopes it could be replicated in humans.
Category: life extension – Page 353
Cognitive Behavioural Therapy (CBT) for patients with social anxiety not only helps to reduce anxiety levels but also seems to protect against accelerated cellular ageing, a study involving researchers at Karolinska Institutet published in the journal Translational Psychiatry reports.
“This is the first step towards better understanding the link between cellular ageing and the treatment of psychiatric issues,” says lead author Kristoffer Månsson, researcher at the Department of Clinical Neuroscience at Karolinska Institutet in Sweden.
Individuals affected by mental illness are at greater risk of developing somatic conditions, such as high blood pressure and diabetes, earlier in life than unaffected individuals. While the reasons for this are unclear, one possible contributory factor is that mental health disorders are associated with shorter telomeres and accelerated cellular ageing.
Article courtesy of Dr. Nicholas DiNubile, Vice President of the A4M, an orthopedic surgeon specializing in sports medicine, best selling author, keynote speaker, and one of our medical editors who is dedicated to keeping you healthy in body, mind and spirit.
We’ve extended the warranty on the human heart, and people are living longer. We’ve improved care for skin, and people look better. But it’s your frame that gets you where you need to go whenever you need to get there. Without the proper care, your bones and joints can all too easily become the limiting factor in your enjoyment of life. Have you outlived the warranty on your frame? Would you like an extended warranty?
I have come to believe that the achievement of longevity will bring the challenge of durability to the forefront of modern healthcare.
Turning Back Time
Posted in life extension
Wish you could still be YOU… only younger? Learn how science is turning back time
Part 3 of a series on the mission to defy aging
There it was…in large, bold letters… Turn Back Time.
Progress in research is not linear. Periods characterized by rates of incremental knowledge are interlaced with “eureka” moments as milestone discoveries suddenly open new possibilities that thrust research and knowledge to a higher level. Galileo’s use of the telescope to explore the stars, Kary Mullis’s description of polymerase chain reaction, and Edwin Hubble’s demonstration that the universe is expanding are just few examples of these moments. The field of aging research is living one of those magical moments. Finding a reference metric for the rate of biological aging is key to understanding the molecular nature of the aging process. Defining and validating this metric in humans opens the door to a new kind of medicine that will overcome the limitation of current disease definitions, approaching health in a global perspective and bringing life course preventative measures to the center of attention.
Scientists like Prof Sinclair have evidence of speeding up, slowing, and even reversing aging.
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What causes aging? According to Professor David Sinclair, it is a loss of information in our epigenome, the system of proteins like histones and chemical markers like methylation that turn on and off genes. Epigenetics allow different cell types to perform their specific functions — they are what differentiate a brain cell from a skin cell. Our DNA is constantly getting broken, by cosmic rays, UV radiation, free radicals, x-rays and regular cell division etc. When our cells repair that damage, the epigenome is not perfectly reset. And hence over time, noise accumulates in our epigenome. Our cells no longer perform their functions well.
To counter this decline, we can activate the body’s own defenses against aging by stressing the body. Eat less, eat less protein, engage in intense exercise, experience uncomfortable cold. When the body senses existential threats it triggers longevity genes, which attempt to maintain the body to ensure its survival until good times return. This may be the evolutionary legacy of early bacteria, which established these two modes of living (repair and protect vs grow and reproduce). Scientists are uncovering ways to mimic stresses on the body without the discomfort of fasting. Molecules like NMN also trigger sirtuins to monitor and repair the epigenome. This may slow aging.
Reversing aging requires an epigenetic reset, which may be possible using Yamanaka factors. These four factors can revert an adult cell into a pluripotent stem cell. Prof. Sinclair used three of the four factors to reverse aging in the retinal cells of old mice. He found they could see again after the treatment.
Hayley Harrison is on a constant Roll… Here she sent me privately this video of the great Bill Faloon… I have not completed the video as yet… But the beginning is awesome I will watch late tonight during my down time… Great Respect to Life Extension and Bill Faloon and Neal Francis Vanderee two of the Longevity Movements most interesting characters and the movements many activists such as Hayley “the watchful” Harrison… AEWR.
My mission is to drastically improve your life by helping you break bad habits, build and keep new healthy habits to make you the best version of yourself.
This video is my interview of longevity pioneer Bill Faloon on December 17, 2019.
A new study sheds light on the accumulation of senescent cells and suggests that therapies that remove them could be beneficial both immediately and in the long term for human health and longevity.
Normally, as cells become damaged beyond repair, exhausted, and no longer able to replicate, they are removed from the body via a process known as apoptosis, which is a kind of self-destruct program initiated by the cell, or removed by the immune system. This system acts as a safety net to prevent damaged cells from remaining active and, in the context of cells damaged by mutations, a way to prevent cancer.
Unfortunately, as we age, this disposal system, like many others in our body, begins to falter and ultimately fail. This leads to the accumulation of unwanted, damaged senescent cells in every tissue of our body. This build-up of senescent cells is one of the proposed reasons we age and has been the focus of intense research in the last few years.