“Unprecedented results” showed that longer than normal telomeres in mice hahd only beneficial effects, such as increased longevity, delayed metabolic age and fewer cancers.
Category: life extension – Page 351
A recent study has taken an in-depth look at the age-related changes that occur in the microbiome, particularly in regards to bacterial populations.
A detailed look at bacterial populations in the gut microbiome
The publication contains multiple graphs that track age-related changes to various bacterial populations in the gut. These graphs show a common trend: the abundance of these bacterial species increases with aging but then falls significantly in extreme old age. On these charts, Groups 1–5 contain various ages of children, Group 6 consists of 19- to 29-year-olds, and each following group is ten years older than the previous, with Group 14 containing 99- to 110-year-olds.
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MOTHERBOARD met up with Russian billionaire Dmitry Itskov at his Global Future 2045 Conference in New York City to talk about immortality, spirituality, and the coming age of cybernetic avatar-based living.
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In mouse studies, a “methylation clock” on the ELOVL2 gene ticks toward impaired vision, but when gene expression was boosted, age-related visual function improved.
A lengthy-named gene called Elongation of Very Long Chain Fatty Acids Protein 2 or ELOVL2 is an established biomarker of age. In a new paper, published online January 14, 2020 in the journal Aging Cell, researchers at University of California San Diego School of Medicine say the gene appears to play a key role in age-associated functional and anatomical aging in vivo in mouse retinas, a finding that has direct relevance to age-related eye diseases.
Specifically, the research team, led by senior author Dorota Skowronska-Krawczyk, PhD, assistant professor in the Viterbi Family Department of Ophthalmology at UC San Diego Shiley Eye Institute, found that an age-related decrease in ELOVL2 gene expression was associated with increased DNA methylation of its promoter. Methylation is a simple biochemical process in which groups of carbon and hydrogen atoms are transferred from one substance to another. In the case of DNA, methylation of regulatory regions negatively impacts expression of the gene.
When researchers reversed hypermethylation in vivo, they boosted ELOVL2 expression and rescued age-related decline in visual function in mice. “These findings indicate that ELOVL2 actively regulates aging in mouse retina, provides a molecular link between polyunsaturated fatty acids elongation and visual functions, and suggests novel therapeutic strategies for treatment of age-related eye diseases,” wrote the authors.
“A neuroscientist explains how our brains age and provides tips for aging with more vitality and happiness.”
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About 13 years ago, I watched my very vital mother die a slow death from Lewy-Body dementia. For me, it was a wakeup call. If there were anything I could do to stay healthy myself—to avoid the slow decline of an aging brain—I wanted to do it. But what really helps us stay sharp longer? And how can we separate fad ideas from solid, evidence-based advice around aging?
AgeX Therapeutics Inc (NYSEAMERICAN: AGE) CEO Michael West sat down with Proactive’s Christine Corrado at the Biotech Showcase 2020 in San Francisco. The Alameda, California biotechnology company is developing a cell therapy treatment for metabolic disorders such as Type 2 diabetes.
Against All Odds
Posted in biotech/medical, life extension
Jane McLelland beat cervical, lung, and blood cancers using the missing link to defeat cancer: starving it. She is partnering with Life Extension® to help other patients achieve the same results.
By Laurie Mathena.
After getting a considerable success in convincing scientists and investors, in the last decades, that undoing aging through a damage repair approach is possible and desirable, Aubrey de Grey is turning his advocacy efforts to politicians. In this video, he explains why.
Aubrey de Grey delivers a keynote on the next steps for longevity for policy makers.
Dr Aubrey de Grey is a biomedical gerontologist based in Mountain View, California, USA, and is the Chief Science Officer of SENS Research Foundation, a California-based 501©(3) biomedical research charity that performs and funds laboratory research dedicated to combating the ageing process. He is also VP of New Technology Discovery at AgeX Therapeutics, a biotechnology start up developing new therapies in the field of biomedical gerontology. In addition, he is Editor-in-Chief of Rejuvenation Research, the world’s highest-impact peer-reviewed journal focused on intervention in ageing. He received his BA in computer science and Ph.D. in biology from the University of Cambridge. His research interests encompass the characterisation of all the types of self-inflicted cellular and molecular damage that constitute mammalian ageing and the design of interventions to repair and/or obviate that damage. Dr de Grey is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organisations. He is a highly sought-after speaker who gives 40–50 invited talks per year at scientific conferences, universities, companies in areas ranging from pharma to life insurance, and to the public.
There are a few dozen antiaging rejuvenation treatments that are progressing through pre-clinical and clinical trials.
Lifespan.io is tracking the antiaging rejuvenation treatments on a rejuvenation roadmap.
Two treatments are in phase 3 clinical trial.