Toggle light / dark theme

From insilico meddicine — the beginning of an AI healthcare revolution.


Poly Mamoshina on Machine Learning for small molecule drug discovery and the beginning of an AI healthcare revolution — interviewed at the Undoing Aging conference in Berlin 2019!

Polina Mamoshina is a senior research scientist at Insilico Medicine, Inc (www.insilico.com), a Baltimore-based bioinformatics and deep learning company focused on reinventing drug discovery and biomarker development and a part of the computational biology team of Oxford University Computer Science Department. Polina graduated from the Department of Genetics of the Moscow State University. She was one of the winners of GeneHack a Russian nationwide 48-hour hackathon on bioinformatics at the Moscow Institute of Physics and Technology attended by hundreds of young bioinformaticians. Polina is involved in multiple deep learning projects at the Pharmaceutical Artificial Intelligence division of Insilico Medicine working on the drug discovery engine and developing biochemistry, transcriptome, and cell-free nucleic acid-based biomarkers of aging and disease. She recently co-authored seven academic papers in peer-reviewed journals.

A new study shows that short-term treatment with the common organ rejection drug rapamycin reverses periodontal bone loss, attenuates inflammation, and makes the oral microbiome revert to a more youthful state in old mice.

What is rapamycin?

Rapamycin (also known as sirolimus) is a macrolide, a class of antibiotics that includes Biaxin (Clarithromycin), Zithromax (Azithromycin), Dificid (Fidoximycin), and Erythromycin. Macrolides inhibit the growth of bacteria and are often used in the treatment of common bacterial infections.

A global movement.


Click here to open page.

Aubrey de Grey will be the opening speaker at our launch meeting. He will discuss the need for an organized Health and Life Extension movement and related topics. Q and A to follow.

We are working with Aubrey de Grey — CSO of SENS, Jim Strole — head of RAADfest, Michael West — CEO of AgeX (founder of Geron and ACT), Steve Garan — CTO of Trans-Time (cryonics), and other leaders and leading organizations on the project herewith.

From the beginning of time, humankind has searched for the secret to a long life. Now science may have found an answer, in the form of molecular augury. The pattern of chemical chains that attach to the DNA in your cells—on-off switches known as epigenetic markers—can reveal how swiftly you are aging, and perhaps even how much longer you will live. While genetic testing might tell you where you came from, epigenetics promises a glimpse into the future. Now, a handful of companies are offering commercial blood or saliva tests based on the science of epigenetics—a chance to find out how old you truly are.


Companies claim they can now easily calculate your biological age. Should you take them up on it?

Objective Failing to properly repair damaged DNA drives the ageing process. Furthermore, age-related inflammation contributes to the manifestation of ageing. Recently, we demonstrated that the efficiency of repair of diethylnitrosamine (DEN)-induced double-strand breaks (DSBs) rapidly declines with age. We therefore hypothesised that with age, the decline in DNA damage repair stems from age-related inflammation.

Design We used DEN-induced DNA damage in mouse livers and compared the efficiency of their resolution in different ages and following various permutations aimed at manipulating the liver age-related inflammation.

Results We found that age-related deregulation of innate immunity was linked to altered gut microbiota. Consequently, antibiotic treatment, MyD88 ablation or germ-free mice had reduced cytokine expression and improved DSBs rejoining in 6-month-old mice. In contrast, feeding young mice with a high-fat diet enhanced inflammation and facilitated the decline in DSBs repair. This latter effect was reversed by antibiotic treatment. Kupffer cell replenishment or their inactivation with gadolinium chloride reduced proinflammatory cytokine expression and reversed the decline in DSBs repair. The addition of proinflammatory cytokines ablated DSBs rejoining mediated by macrophage-derived heparin-binding epidermal growth factor-like growth factor.

Rejuvenation Roundup November 2019


Quite a number of readily understandable reviews were published this month, along with an X10 episode on epigenetic alterations; if you’re new to the biology of aging or want to introduce someone else to the topic with new material, this is a great time to start.

LEAF News

We will be returning to New York in 2020 for our third conference focused on aging research, investment, and biotech business. Judy Campisi, Aubrey de Grey, Hanadie Yousef, Steve Horvath, Andrei Gudkov, and Polina Mamoshina are among the speakers confirmed so far. Join the conference mailing list to stay informed as more details are announced.

This study involved 4,717 participants from two different community-based cohorts. A meta-analysis of both cohorts showed that elevated sCD14 was associated with a 12 percent increased risk of dementia as people got older. Higher levels of sCD14 were also associated with accelerated brain aging in both cohorts, a faster progression of age-related brain atrophy, and a more rapid decline of executive functions.

The authors sum up their findings: “sCD14 is an inflammatory marker related to brain atrophy, cognitive decline, and incident dementia.”

“Higher levels of sCD14 were associated with markers of brain aging and injury, such as total brain atrophy and a decline in executive functioning—the decision-making needed for many activities of daily life,” first author Matthew Pase, of the Florey Institute for Neuroscience and Mental Health in Melbourne, Australia, said in a news release.

You are invited to Perpetual Life for The Remembrance of the Resurrectables and Age Reversal & Cryonics by Bill Faloon.

Before and After the service, we will celebrate the Remembrance of the Resurrectables in the Sanctuary, A ceremony of remembering all of the patients that are in Cryonic Suspension.

Before the service: Enjoy tasty snacks, networking and conversations on Age Reversal, Cryonics, The Singularity and other topics of interest to all for the quest of an Unlimited Life. Stay afterwards as we have a delicious 5 star dinner reception with speakers.

Bring a friend! Someone that you would like to share news of amazing emerging technologies on Health & Extreme Longevity!