The death of cash is still some way off, but a tipping point is fast approaching helped by consumer realisation that contactless payments are more secure and more convenient.
Category: life extension – Page 327
Ribonucleic acid, or RNA, is part of our genetic code and present in every cell of our body. The best known form of RNA is a single linear strand, of which the function is well known and characterized. But there is also another type of RNA, so-called “circular RNA,” or circRNA, which forms a continuous loop that makes it more stable and less vulnerable to degradation. CircRNAs accumulate in the brain with age. Still, the biological functions of most circRNAs are not known and are a riddle for the scientific community. Now scientists from the Max Planck Institute for Biology of Aging have come one step closer to answer the question what these mysterious circRNAs do: one of them contributes to the aging process in fruit flies.
Carina Weigelt and other researchers in the group led by Linda Partridge, Director at the Max Planck Institute for Biology of Aging, used fruit flies to investigate the role of the circRNAs in the aging process. “This is unique, because it is not very well understood what circRNAs do, especially not in an aging perspective. Nobody has looked at circRNAs in a longevity context before,” says Carina Weigelt who conducted the main part of the study. She continues: “Now we have identified a circRNA that can extend lifespan of fruit flies when we increase it, and it is regulated by insulin signaling.”
Animal experiments demonstrating the anti-aging effects of exchanging young blood plasma for old have been prominent in the last two months. Several groups are saying it’s time to translate their findings into human trials. But I’ve recently learned that others have been doing this for several years. What can we learn from their results to guide the next steps in experimentation?
I had never heard of Grifols, the Spanish pharmaceutical company that is the world’s largest supplier of albumin. Since 2005, Grifols has been quietly funding world leaders in plasma exchange research in humans. Albutein ® is their brand-name solution of human albumin.
Last month, the first results of the Grifol’s AMBAR trial were released. (AMBAR stands for A lzheimer’s M odulation B y A lbumin R eplacement). It was a much larger-scale phase 2.5 trial, with 496 subjects recruited from sites in Spain and USA, and treated for 14 months. A single treatment consisted of removing 2.5 to 3 litres of blood (more than half the body’s inventory) and replacing it with Albutein. Patients began with 6 weekly treatments, and thereafter there were 12 monthly smaller plasma replacements (0.7 litres), again with Albutein.
Happy birthday to the World most important Entrepreneur (Olorogun Elon Musk). We at the Ogba Educational Clinic and Artificial intelligence Hub celebrate and wish to immortalize you by Setting up a club after you (The Elon Musk Club). This is in line with our vision to create small Elon’s that would eventually outdo you from Africa.
Dean Kamen, the inventor of the Segway, is currently spearheading a project to convert part of the old New Hampshire textile plant into a factory for lab-grown lungs, livers, and other organs for transplantation — and he doesn’t think it’ll take long to do it.
The nonprofit is like a club for tissue engineering and regenerative medicine researchers. Groups must have something to offer in order to join (money, equipment, experience), but once a part of ARMI, they gain access to the other members’ research and resources.
The Longevity Vision Fund invests in technologies, products, and services that extend healthy human lifespans and decrease negative aging effects.
Fat cell aspirste can be part of regenerative medicine treatments for degenerated body tissues such as joints, muscles, tendon and ligaments.
Fantastic article on Dr Yuancheng Ryan Lu’s age reversal experiment.
“ It suggests that it is entirely possible to reverse aging in cells with the use of a molecular mechanism already present in the cells. And so, scientists are now off to the races in the hopes of finding this cellular mechanism, and ways to activate this correction system in living beings…”
In 2006, Dr. Shinya Yamanaka, a Japanese stem cell researcher, published his paper on induced pluripotent stem cells, and it changed the medical world. Dr. Yamanaka had found a way to convert a mature skin cell into a stem cell by injecting just a few genes. And for this, Dr. Yamanaka received the Nobel Prize in Physiology or Medicine in 2012, sharing it with another Sir John B. Gurdon, who found another method of inducing pluripotency.
Thirteen years after this paper was published (in 2019), Dr. Yuancheng Lu from the Sinclair Lab at Harvard University authored another paper (still being peer-reviewed) where he had used Dr. Yamanaka’s breakthrough to reverse aging.
One of the world’s greatest anti-aging scientists continues his groundbreaking efforts. In the photo next to Dr David Sinclair, there is a fella who kind of looks like my friend, Dr Yuancheng Ryan Lu. Is that you? (Dr Lu has confirmed that he is indeed the scientist on the right. Dr Sinclair is on the left.)
I can’t wait to see what they develop next!
Harvard scientist David Sinclair is one of Longevity’s big hitters. Just a year after raising $50M in Series B financing, his company Life Biosciences LLC is looking for $100M to progress its anti-aging research [1].
Longevity. Technology: Life Biosciences had an original Series B goal of $25M; it doubled it. As NAD continues to embed in the anti-aging supplement marketplace, the company is looking to expand, with a range of subsidiaries under its Longevity umbrella. Although the company isn’t spilling any secrets on its proposed clinical trials, we will be sure to keep a close eye on progress.