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Category: life extension – Page 323

Intermittent fasting in mice effective at promoting long term memory retention

Might interest some.

A new study from the Institute of Psychiatry, Psychology and Neuroscience (IoPPN) at King’s College London has established that Intermittent Fasting (IF) is an effective means of improving long term memory retention and generating new adult hippocampal neurons in mice, in what the researchers hope has the potential to slow the advance of cognitive decline in older people.

The study, published today in Molecular Biology, found that a calorie restricted via every other day fasting was an effective means of promoting Klotho gene expression in mice. Klotho, which is often referred to as the “longevity gene” has now been shown in this study to play a central role in the production of hippocampal adult-born new neurons or neurogenesis.

Adult-born are important for formation and their production declines with age, explaining in part cognitive decline in older people.

Regenerative medicine: breaking the wall of scepticism

Is this the reason why the general public view the emerging field of regenerative medicine with such scepticism? Has a combined cultural history of being bombarded with empty promises of longevity made us numb to such a prospect? Possibly, although I believe it might go deeper than old fashioned scepticism. After all, our species is hardly a stranger to believing something if we desire for it to be true, regardless of how much evidence is presented to us.

Maybe we are simply experiencing just another example of humans finding dramatic change to our way of life hard to comprehend and accept. After all, practically every major change in our recent history was largely believed to be an impossibility by the general public, right up until the point that it became the norm. Everything from the aeroplane to the internet was seen as science fiction, but yet today they are integral parts of our lives. Now, this is not to say that everything the general public is sceptical of will inevitably turn out to prove them wrong, but lessons from our history do show that when it comes to scientific progress, the public will not believe it until they can see it.

Some would believe that scepticism towards regenerative medicine strikes at something much deeper in our psych, as it threatened to fundamentally change our entire outlook on the world. For our entire lives, we have been taught by our interactions with others exactly how life is supposed to progress. You are supposed to suffer a gradual decay of mental and physical abilities, until eventually you die. That is just how it is, and if that were to ever change then we would all have to change how we think about the world. The concept of a 125 year old with the appearance of a 25 year old seems bizarre to us right now, and to many the idea of ever lasting health just goes against their fundamental beliefs of how the world functions to such an extent that they cannot comprehend anything different. Some would even go far as to defend the ageing process as being an integral part of life, displaying what can only be described as ‘Stockholm syndrome with extra steps’.

Mediterranean Diet for Longevity

I could find hardly any scientific studies that showed negative results from the Mediterranean Diet for longevity, which honestly makes me a little wary of scientific establishment groupthink.

That said, I think I am going to start taking shots of olive oil after all my research…

Is the Mediterranean Diet the key to longevity? Lots of research suggests olive oil and other Mediterranean foods can help you live longer.

Are There Foods That Can Increase NAD? (Part II)

Papers referenced in the video:

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence:
https://pubmed.ncbi.nlm.nih.gov/29514064/

NAD and the aging process: Role in life, death and everything in between:
https://pubmed.ncbi.nlm.nih.gov/27825999/

Flavonoids as inhibitors of human CD38:
https://pubmed.ncbi.nlm.nih.gov/21641214/

Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome:
https://pubmed.ncbi.nlm.nih.gov/23172919/

Characterization of Anthocyanins and Proanthocyanidins in Some Cultivars of Ribes, Aronia, and Sambucus and Their Antioxidant Capacity:

Continue reading “Are There Foods That Can Increase NAD? (Part II)” | >

Polycarpa mytiligera can regrow all of its organs if dissected into three pieces

It might not look like much, but this little worm could hold the key to biological regeneration!

Researchers have made an extraordinary discovery using a creature in common to the Gulf of Eilat. The creature is called Polycarpa mytiligera and is a species of ascidian, which is a marine animal commonly found in the waters of the Gulf that is capable of regenerating its organs. Surprisingly, the researchers discovered the animal can regenerate all of its organs even when dissected into three fragments.

Scientists say that is an astounding discovery because it’s an animal belonging to the Phylum Chordata, which are animals with a dorsal cord, which also includes humans. The ability to regenerate organs itself is not uncommon in the animal kingdom. One example is the gecko able to regrow its tail. However, it’s not common for creatures to be able to regrow entire body systems.

With the Polycarpa mytiligera, scientists have discovered a creature able to regenerate all organs even if separated into three pieces, each piece knowing exactly how to regain the function of all of its missing body systems within a short period. Project researcher Tal Gordon says that by all accounts, the ascidian is a simple organism with two openings in its body, and inside the body is a central organ resembling a pasta strainer.

Scientists use genetic engineering to increase worm’s lifespan

To answer this question, an internal team of scientists, consisting of researchers affiliated with the Buck Institute for Research on Ageing, and researchers from Nanjing University decided to modify both the Insulin and the rapamycin pathways of a group of C.elegans worms, expecting to see a cumulative result of a 130% increase in lifespan. However, instead of seeing a cumulative effect in lifespan, the worms lived five times longer than they normally would.

“The synergistic extension is really wild. The effect isn’t one plus one equals two, it’s one plus one equals five. Our findings demonstrate that nothing in nature exists in a vacuum; in order to develop the most effective anti-aging treatments we have to look at longevity networks rather than individual pathways.” – Jarad Rollins of Nanjing University.

What could this mean for human regenerative medicine? Humans are not worms, however on a cellular level they do possess very similar biology. Both the insulin pathway and the rapamycin pathway are what is known as ‘conserved’ between humans and C.elegans, meaning that these pathways have been maintained in both organisms. In the distant past, both humans and C.elegans had a common ancestor, in exactly the same way as humans and Chimpanzees have a common ancestor. Evolution has changed our bodies significantly over the millions of years that humans and C.elegans have diverged from one another, but a lot of our fundamental biological functions remain largely unchanged.

Boys Born Very Prematurely May Age Faster as Men

**Low birth weight tied to accelerated aging in boys**

A study in Pediatrics found that boys who weigh less than 2 pounds at birth aged faster and were five years older biologically in their early 30s, compared with boys who were born at the same time but whose birth weights were normal. The findings were based on the genes of 45 individuals who were extremely low birth weight and those of 47 whose birth weights were normal.

MONDAY, May 17, 2021 (HealthDay News) — Boys who weigh less than 2 pounds at birth don’t age as well as their normal-weight peers, a long-term study finds.

Canadian researchers have followed a group of extremely low birth weight (ELBW) babies and their normal-weight counterparts since 1977.

When participants were in their early 30s, researchers compared the genes of 45 who were ELBW babies with those of 47 whose birth weight was normal.

Genetic tricks of the longest-lived animals

The secret to longevity is already in the animals around us.

Some species live unexpectedly long lives. By studying how they do it, researchers hope to pinpoint factors affecting human longevity.

By Bob Holmes.

Life, for most of us, ends far too soon — hence the effort by biomedical researchers to find ways to delay the aging process and extend our stay on Earth. But there’s a paradox at the heart of the science of aging: The vast majority of research focuses on fruit flies, nematode worms and laboratory mice, because they’re easy to work with and lots of genetic tools are available. And yet, a major reason that geneticists chose these species in the first place is because they have short lifespans. In effect, we’ve been learning about longevity from organisms that are the least successful at the game.

Fighting Aging With Gene Therapies | Liz Parrish Interview Series Episode 2

Most important part comes at 1:49 where Liza talks about gene therapies for people to stop people from aging, reaching homeostasis, or even exceeding it a little bit.

In this video Liz introduces BioViva Science and how the company works with its partners in delivering gene therapies.

Liz Parrish is the Founder and CEO of BioViva Sciences USA Inc. BioViva is committed to extending healthy lifespans using gene therapy. Liz is known as “the woman who wants to genetically engineer you,” she is a humanitarian, entrepreneur, author and innovator and a leading voice for genetic cures. As a strong proponent of progress and education for the advancement of gene therapy, she serves as a motivational speaker to the public at large for BioViva and the life sciences. She is actively involved in international educational media outreach and is a founding member of the International Longevity Alliance (ILA). She is the founder of the BioTrove Podcasts, found at iTunes, which is committed to offering a meaningful way for people to learn about current technologies. She is also a founding member of the American Longevity Alliance (ALA) a 501©(3) nonprofit trade association that brings together individuals, companies, and organizations who work in advancing the emerging field of cellular & regenerative medicine with the aim to get governments to consider aging a disease.

BioViva https://bioviva-science.com.
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Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. It is the responsibility of you and your healthcare providers to make all decisions regarding your health. Products or services mentioned in this video are not a recommendation or medical advice.

Continue reading “Fighting Aging With Gene Therapies | Liz Parrish Interview Series Episode 2” | >

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