The results of this study demonstrate a clear relationship between psychopathology and rate of aging. Remarkably, this relationship was obvious by the age of 45. By that time, those with the upper 10% of psychopathology factor (p-factor) scores had aged approximately 5.3 more years than those with the lowest 10% of p-factor scores.
Is a history of psychiatric illness associated with more rapid aging?
Given the rate of overweight and obese people in the Western world, there are inevitably lots of fat people interested in life extension. Assuming that weight-loss trends continue with a high failure rate, the majority of fat spanners will not be able to lose and maintain their weight loss through diet and exercise.
This article explores effective life-extension interventions that do not include weight loss for people with an excess of adipose tissue.
Is it possible to be fat and healthy? Is obesity a death sentence? Learn about what the science says about life extension when fat.
Here’s my latest video!
Papers referenced in the video:
The Hallmarks of Aging: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/
Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859450/
Telomeres and the natural lifespan limit in humans: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425118/
Bill Faloon’s newest Age Reversal Update.
“Our task is to make nature, the blind force of nature, into an instrument of universal resuscitation and to become a union of immortal beings.“
- Nikolai F. Fedorov.
We hold faith in the technologies & discoveries of humanity to END AGING and Defeat involuntary Death within our lifetime.
Working to Save Lives with Age Reversal Education.
========== Perpetual Life Creed ==========
We believe that all of life is sacred and that we have been given this one life to make unlimited. We believe in our Creator’s divine plan for all of humanity to have infinite lifespans in perfect health and eternal joy, rendering death to be optional.
Antiaging expert Aubrey de Grey says there is a 50% chance that we reach longevity escape velocity by 2035.
I now think there is a 50% chance that we will reach longevity escape velocity by 2036. After that point (the “Methuselarity”), those who regularly receive the latest rejuvenation therapies will never suffer from age-related ill-health at any age.
— Aubrey de Grey (@aubreydegrey) March 142021
Dedicated to those who argue that life extension is bad because it will create overpopulation problems. In adittion to the fact that natality rates are dangerously decreasing in some developed countries, this is only one example of changes that may will take place well before life extension may create a problem of such type, if ever.
Plenty, an ag-tech startup in San Francisco co-founded by Nate Storey, has been able to increase its productivity and production quality by using artificial intelligence and its new farming strategy. The company’s farm farms take up only 2 acres yet produce 720 acres worth of fruit and vegetables. In addition to their impressive food production, they also manage the production with robots and artificial intelligence.
The company says their farm produces about 400 times more food per acre than a traditional farm. It uses robots and AI to monitor water consumption, light, and the ambient temperature of the environment where plants grow. Over time, the AI learns how to grow crops faster with better quality.
While this is great for food quality, it also helps conserve resources. The water is recycled and evaporated water recaptured so there is virtually no waste. The Startup estimates that this smart farm is so efficient that it produces better fruits and vegetables using 95% less water and 99% less land than normal farming operations.
Should interest those into links on aging/longevity and neuroscience.
The mammalian center for learning and memory, hippocampus, has a remarkable capacity to generate new neurons throughout life. Newborn neurons are produced by neural stem cells (NSCs) and they are crucial for forming neural circuits required for learning and memory, and mood control. During aging, the number of NSCs declines, leading to decreased neurogenesis and age-associated cognitive decline, anxiety, and depression. Thus, identifying the core molecular machinery responsible for NSC preservation is of fundamental importance if we are to use neurogenesis to halt or reverse hippocampal age-related pathology.
While there are increasing number of tools available to study NSCs and neurogenesis in mouse models, one of the major hurdles in exploring this fundamental biological process in the human brain is the lack of specific NSCs markers amenable for advanced imaging and in vivo analysis. A team of researchers led by Dr. Mirjana Maletić-Savatić, associate professor at Baylor College of Medicine and investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, and Dr. Louis Manganas, associate professor at the Stony Brook University, decided to tackle this problem in a rather unusual way. They reasoned that if they could find proteins that are present on the surface of NSCs, then they could eventually make agents to “see” NSCs in the human brain.
“The ultimate goal of our research is to maintain neurogenesis throughout life at the same level as it is in the young brains, to prevent the decline in our cognitive capabilities and reduce the tendency towards mood disorders such as depression, as we age. To do that, however, we first need to better understand this elusive, yet fundamental process in humans. However, we do not have the tools to study this process in live humans and all the knowledge we have gathered so far comes from analyses of the postmortem brains. And we cannot develop tools to detect this process in people because existing NSC markers are present within cells and unreachable for in vivo visualization,” Maletić-Savatić said. “So, in collaboration with our colleagues from New York and Spain, we undertook this study to find surface markers and then develop tools such as ligands for positron emission tomography (PET) to visualize them using advanced real-time in vivo brain imaging.”
Following on in the vein of my recent topics, this week I am looking at mTOR. A crucial protein that performs the function of an enzyme that is critical for day to day function. There are so many terms and words, subjects and strategies, abound, and so many talk in terms where a basic understanding of the subject is necessary to benefit fully, that I decided to create a kind of library, or resource where you can brush up on all the core fundamentals. Should you stimulate mTOR or seek to restrict it? What will happen if I do? Is this a short term strategy or a lifestyle goal? And what is the real state of the science that underpins it all? These are all questions you, or friends, may have, or even may have heard but been unable to answer fully or concisely, hopefully these will help to reduce those issues. Next week I will be looking at its partner in crime, AMPK, together they exist in balance like a playground see-saw… Until then, have an amazing day…
In this video I will look at what mTOR is and how you can harness it to benefit your objectives. By controlling it we can achieve the balance we need which is to grow muscle to stay fit and strong, but also to not burn out too quickly, so we can live a long healthy life, with a long health span. Maximising anti aging to aid in longevity is delicate balance unique to us all and which varies depending on our current goals and objectives.
By learning how all these systems interrelate and interact, we can find the best pathway for our own personal journey, I hope this video goes some way to helping you chart that path.
If you want to know more about rapamycin which is the mTOR inhibitor mentioned, why not try this video next…
https://youtu.be/mbszWs1JX7c.
As always the links to the studies and information I referenced is below…
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A bi-weekly virtual town hall-like show presenting in-depth discussions on issues connected to African advancement in the 21st century ranging from science, technology, … See More.
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Mission.
Creating a space for discussions on ideas and issues related to the African condition, and develop a suitable narrative through multidimensional approaches to drive progress in Africa towards a sustainable and more prosperous future.
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Building from the present and critically reconstructed African past for a greater, highly advanced, cosmopolitan, peaceful, and prosperous future African civilization through meaningful and fruitful discourse and action.
Holding: TAFFD’s Africa.