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Category: life extension – Page 299

Natural Compound in Basil May Protect Against Alzheimer’s Disease

“Our study is the first to discover that stimulation of the FFAR2 sensing mechanism by these microbial metabolites (SCFAs) can be beneficial in protecting brain cells against toxic accumulation of the amyloid-beta (Aβ) protein associated with Alzheimer’s disease,” said principal investigator Hariom Yadav, PhD, professor of neurosurgery and brain repair at the USF Health Morsani College of Medicine, where he directs the USF Center for Microbiome Research.

Fenchol, a natural compound abundant in some plants including basil, can help protect the brain against Alzheimer’s disease pathology, a preclinical study led by University of South Florida Health (USF Health) researchers suggests.

The new study published Oct. 5 in the Frontiers in Aging Neuroscience, discovered a sensing mechanism associated with the gut microbiome that explains how fenchol reduces neurotoxicity in the Alzheimer’s brain.

How You Will Live to 200 Years — New Longevity Technologies

I hope we get the hologram interfaces depicted too.

It’s becoming clear that aging is just as curable as other diseases such as the cold or a broken bone. Advancements in biotechnology now allow for targeted gene therapy and supplements to be invented that can both stop aging and even reverse the aging process through new Longevity Technology. The field of Longevity has expanded and evolved a lot during the past few years and have invented new treatments for diseases of old people which could increase the average lifespan of people by a ton according to the leading scientists such as David Sinclair and Aubrey De Grey. Anti Aging Supplements such as Metformin and NAD+, NMN are just the start.
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Every day is a day closer to the Technological Singularity. Experience Robots learning to walk & think, humans flying to Mars and us finally merging with technology itself. And as all of that happens, we at AI News cover the absolute cutting edge best technology inventions of Humanity.

If you enjoyed this video, please consider rating this video and subscribing to our channel for more frequent uploads. Thank you! smile
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TIMESTAMPS:
00:00 A new Benchmark in Longevity.
01:04 Living longer lives today.
03:13 How Genomics will extend our lifespans.
05:19 What are the societal concerns?
07:58 Last Words.
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#longevity #immortality #treatment

Larry Curley — Executive Director — The National Indian Council on Aging (NICOA)

Comprehensive health, social services and economic well-being for american indian and alaska native elders — larry curley, executive director, national indian council on aging.

Mr. Larry Curley is Executive Director of The National Indian Council on Aging (https://www.nicoa.org/), a 501©(3) nonprofit organization founded in 1976 by members of the National Tribal Chairmen’s Association who called for a national organization focused on the needs of aging American Indian and Alaska Native elders. The mission of NICOA is to advocate for improved comprehensive health, social services and economic well-being for American Indian and Alaska Native elders.

Mr. Curley is a member of the Navajo Nation with over 40 years of experience working in the aging and healthcare fields. He has worked with Congress, other branches of the federal government, and national organizations on aging to develop support for programs affecting elder American Indians.

After receiving his master’s degree in public administration at the University of Arizona, along with a certificate in gerontology, Mr. Curley worked as a gerontological planner at an Area Agency on Aging in Pima County, Arizona, where he was instrumental in establishing a county public fiduciary program. As a lobbyist in Washington, D.C., he successfully advocated for the passage of Title VI of the Older Americans Act, an amendment which he wrote.

Mr. Curley directed the Navajo Nation’s Head Start program, one of the five largest Head Start programs in the country, and has served as a nursing home administrator of a tribal, long-term care facility, a hospital administrator in northern Nevada, and as a college instructor at the University of Nevada-Reno and Eastern Washington University.

Continue reading “Larry Curley — Executive Director — The National Indian Council on Aging (NICOA)” | >

Staying Young: Scientists Discover New Enzymatic Complex That Can Stop Cells From Aging

Scientists in Montreal discover a new enzymatic complex that can stop cells from aging, opening the way to possible new cancer therapies.

Researchers at Université de Montréal and McGill University have discovered a new multi-enzyme complex that reprograms metabolism and overcomes “cellular senescence,” when aging cells stop dividing.

In their study published on September 16 2021, in Molecular Cell, the researchers show that an enzyme complex named HTC (hydride transfer complex) can inhibit cells from aging.

New foundation will distribute $1bn for aging research

“The Foundation has created a unique and transparent mechanism for boosting early longevity research worldwide and ensuring mass public participation in decision making,” said Alex Zhavoronkov, Visionary Board member and an expert in AI-powered drug discovery. “This approach finally allows us to speak about getting closer to the idea of mass adoption of longevity ideas and treatments.”

“Age is the greatest risk factor for nearly every major cause of death and disability in developed nations. Therapeutically targeting biological aging is key to fulfilling the promise of 21st century medicine, and the Foundation is poised to play a central role in making this a reality,” said Matt Kaeberlein, CEO of the American Aging Association and Professor at the University of Washington, where he leads several major initiatives.

“In five years, healthy longevity will not only exist as a lab-proven concept, but will become part of everyone’s life,” said Andrea Maier, Visionary Board member and co-director of the Centre for Healthy Longevity at the National University of Singapore.

Higher rates of mutation alone are not to blame for age-related disease

New research exploring theories of aging has found that small mutations accumulating in DNA are unlikely to be fully responsible for this process.

The research, a collaboration between the Wellcome Sanger Institute, University of Birmingham, University of Edinburgh and others, found that and tissues can accumulate many more than are normally present, without the body showing the features associated with aging.

The new study, published today (30 September) in Nature Genetics, compared DNA taken from individuals with inherited mutations in genes involved in DNA replication with DNA from individuals who have normal versions of these genes. The researchers aimed to understand the impact of defective DNA replication on and features associated with aging. The results suggest that build-up of mutations in is unlikely to be the only factor in the development of age-related disease, adding to the ongoing debate about the causes of aging.

Dr. Evelyne Bischof, MD — Advancing The Frontiers Of Preventative And Precision Longevity Medicine

(https://www.linkedin.com/in/evelyne-yehudit-bischof/) is an expert in internal medicine and oncology, with a focus on preventative and precision medicine, bio-gerontology, and geronto-oncology.

Dr. Bischof is deeply passionate about next-generation medical technology, and the applications of artificial intelligence for biomedical research and practice.

Dr. Bischof spent a decade practicing medicine and performing translational research in Switzerland, US, and China.

Dr. Bischof is a medical doctor with an MD from Max Planck Institute for Molecular Biology and Genetics, and interned at Columbia University, Harvard MGH, and Beth Israel Medical Deaconess.

Dr. Bischof is the author of over 40 peer-reviewed papers and is a frequent speaker at scientific and medical conferences.

Dr. Bischof serves as Assistant Professor — Shanghai University of Medicine and Health Sciences; Associate Faculty Shanghai Jiao Tong University, and Researcher at University Hospital of Basel.

Continue reading “Dr. Evelyne Bischof, MD — Advancing The Frontiers Of Preventative And Precision Longevity Medicine” | >

No Shame In Wanting To Look Younger — It Is Natural And You Might As Well Live Longer

Like many other living organisms, humans are born, survive, compete for resources, reach maturity, reproduce, take care of their young, sometimes the young of their young, continuously decline, and die. Evolution needs us for just two purposes – adapt and reproduce. But, unlike other species, humans are very conscious of their fate. Humans are very much aware that after reaching peak performance they will eventually grow old and die. We are very conscious of our fate after reaching peak performance – loss of function, frailty, and eventual loss of everything we worked so hard to earn.

We observe our parents, and other elderly around them, attend funerals, and understand that eventually we will get into this state. We are also very contempt with that fate as evolution made sure that. The more ambitious of us are trying to advance science, the rest seek refuge in religion, some in philosophy, some in accumulation of wealth, and some see the continuation of ourselves in our children. But despite the many technological advances transpiring in the laboratories all over the world, there is nothing we can do at this point to escape aging. There are diets, exercises, sleep, and supplements, but these provide very marginal benefits. We do not see 120+ old yoga and diet practitioners or marathon runners around. But these simple habits do help look younger longer. And many people that have very harmful habits like smoking but still diet and exercise to look younger.

$1B longevity fund launches to pursue 120+ lifespan

$100 million a year. All you gotta do is apply for funding.

A consortium of biotech founders, clinicians, and leading longevity research institutions announced today the launch of the Longevity Science Foundation. The new Swiss foundation has committed to distributing more than $1 billion over the next ten years to research, institutions and projects advancing healthy human longevity and extending the healthy human lifespan to more than 120 years.

Longevity. Technology: The Foundation is advised by a aptly-named “Visionary Board” of leading longevity researchers, led by Evelyne Bischof and joined by Andrea B Maier, Eric Verdin, Matt Kaeberlein and Alex Zhavoronkov, all key opinion leaders who be top picks for a longevity dream team.

We love the bold and simple drive of the fund– projects that can realise rapid change, making “a significant difference in people’s lives as soon as possible” and setting a hopeful goal of possibly effecting that difference within a five-year time frame.

The Longevity Science Foundation will provide funding to promising longevity research institutions and groups around the world. The focus of the Foundation will be to select support projects in four major areas of healthy longevity medicine and tech – therapeutics, personalised medicine, AI and predictive diagnostics. The Foundation is seeking to fund projects that can make a significant difference in people’s lives as soon as possible – even within five years.

New Insights Into How Metabolism Changes Over the Human Lifespan

Metabolism and total energy expenditure change throughout our lives, and now a new study documents a series of distinct, related changes in unprecedented detail. The data – drawn from a large cohort of humans spanning from birth to old age – shed new light on human development and aging and could help shape targeted nutrition and health strategies across the human lifespan.

The complex machine that is the human body requires a substantial amount of energy to fuel day-to-day physical activity and sustain life. However, while energy use is central to understanding many aspects of human health and physiology, including daily nutritional requirements and metabolic investment in myriad activities, very little is known about total energy expenditure in humans or how it varies over the human lifespan.

Most large-scale surveys of human energy expenditure have focused on basal expenditure, which only accounts for roughly half of total expenditure. And, while doubly labeled water (DLW) studies can provide a measure of total energy expenditure in free-living individuals, they, too, are often limited in sample size and diversity.

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