The link between inflammation, cellular senescence, aging, and cancer is a complex relationship, but a new study sheds light on how these four interact.

The light and dark side of inflammation and cellular senescence

Cellular senescence is a protective mechanism that helps us to stay healthy and avoid cancer by removing damaged and aged cells from the cell cycle while preventing them from creating damaged copies of themselves. Senescent cells are disposed of via a self-destruct process known as apoptosis.

Whenever the topic of increasing human lifespan is discussed the concern is sometimes raised that a longer life would mean a life spent frail and decrepit. This is sometimes known as the Tithonus error and shows a fundamental misunderstanding of the aims of rejuvenation biotechnology. The concern is based on the ancient Greek myth of Tithonus which might be thought of as a cautionary tale warning seekers of an eternal life of its alleged inherent dangers.

The myth of Tithonus in brief

Tithonus, the story goes, was a mere mortal who was in love with Eos, the beautiful titan of the dawn. His feelings were requited, but, unfortunately, their idyll was not destined to last. Being a titan, Eos was also a deity and thus immortal, unlike Tithonus, who one day would die of old age if not of some other cause. Eos thus turned to Zeus and asked him to make Tithonus immortal as well. Zeus granted Eos’ wish, but even this did not solve the two lovers’ problem; the father of the gods had granted Tithonus immortality, not eternal youth.

As we age, the thymus begins to shrink, and fewer numbers of T cells are created and trained to fight. This structural decay of the thymus is one of the main reasons why we become increasingly vulnerable to infectious diseases, such as influenza and pneumonia. The other reason is immune cells becoming senescent.

So, what can we do about it? Check out our new exclusive interview and find out.

For this new book, Jim and Al have spent a year sifting through the cutting-edge research, visiting laboratories and interviewing key opinion leaders in the field of life extension. https://www.juvenescence-book.com/

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My guest today on Stuff That Interests Me is one of Britain’s most successful investors, Jim Mellon.

You’re going to live till your 120.

Jim explains why — a combination of new drugs, technologies and lifestyles. What are you going to do with all your time?

The next great investment trend will be around the fact that we are all going to love a lot longer. Find out more in the this fascinating interview.

By treating one of the root causes of aging – senescent cells – a new class of drugs, known as senolytics, has the potential to treat a wide range of age-related diseases rather than the traditional approach of dealing with them one at a time.

Today we are going to take a look at what senescent cells are, how they contribute to age-related diseases and a new review by the Mayo Clinic that shows what we can do about this problem. We all age, but the research suggests that we may not have to suffer from age-related ill health.