An interesting solution to testing combinations of compounds for longevity effects. As we move into implementing multiple approach therapies eg, SENS, which need several interventions we will need ways to measure their efficacy. Good to see people are thinking about this problem already.
Combination testing can it work? One of the MMTP collaborators Josh Mitteldorf suggests a way we might make it work.
This came up recently and it occurred I never posted this here. This is a lecture by Robert Bradbury, not not Ray Bradbury. I had the pleasure of exchanging a few emails with him. Unfortunately those emails are lost so I cannot share them. He was an advocate of life extension and he was a big thinker. I’ll post both vids and a link to the M-brain page. He is not with us anymore I regret to say. Ready?
Renown aging expert Robert Bradbury discusses whole genome engineering, evolution and aging and ways to defeat aging. His talk touches on many areas including nanotechnology, biology, and computer science. More information can be found at http://manhattanbeachproject.com Follow updates at http://twitter.com/maxlifeorg
Hydras, simple fresh-water animals, have the ability to live forever if kept in ideal conditions, a recent study shows.
The organisms are made mostly of stem cells that have the ability to continually divide, thus constantly renewing the body.
“The differentiated cells of the tentacles and the foot are constantly being pushed off the body and replaced with new cells migrating from the body column,” Daniel Martinez, a biologist at Pomona College, said in a statement.
Death is a disease.
Diseases can and will be cured.
Do the math. wink
Disease GWAS show substantial genetic overlap with longevity. Shown are results for coronary artery disease and Alzheimer’s disease. The y axis is the observed P values for longevity, and the x axis is the expected P values under the null hypothesis that the disease is independent of longevity. The cyan, blue and purple lines show the P values for longevity of the top 100, 250, and 500 disease SNPs from independent genetic loci, respectively. Red lines show the background distribution of longevity P values for all independent genetic loci tested in both the longevity and disease GWAS. The grey horizontal line corresponds to the threshold for nominal significance (P = 0.05) for longevity. Significance of enrichment was determined with the hypergeometric test. (credit: Kristen Fortney et al./PLOS Genetics)
What’s the secret of centenarians who have health and diet habits similar to the average person but have remained active and alert at very old ages?
Genes. That’s according to scientists at Stanford University and the University of Bologna, who have written a new report published in PLOS Genetics, based on their finding of several disease variants that may be absent in centenarians compared to the general population.
Peter Thiel, Paypal founder and Facebook angel investor, explains in a beautiful 1-minute video the true purpose of our lives: to proactively fight aging and defeat death:
“The problem that I remain the most passionate about…fighting and aging and death… There is nothing more natural than for us to fight death.”
Quoted from Richard Dawkins’ book “Unweaving the Rainbow: Science, Delusion and the Appetite for Wonder”.The Richard Dawkins Foundation for Reason and Science (Official)
I am really pleased to announce that our mouse longevity program has finally begun. We have submitted our proposal for funding to Longecity and shortly will begin fundraising so we can begin testing.
You may enjoy our brand new podcast where our project lead explains what the project is about and how we can help develop longevity interventions.
We also have a website at www.majormouse.org
Twitter: https://twitter.com/MajorMouseMMTP
https://www.facebook.com/groups/ MajorMouseTestingProgram /
MMTP — Major Mouse Testing Program.
http://majormouse.org
is a project by the International Longevity Alliance.
http://longevityalliance.org
Podcast Adam Alonzi http://adamalonzi.libsyn.com/
Artwork by Semy Ingle.
Music by Andrew Vavrek of Tryad.
My new article for the International Business Times:
The US presidential candidate completes his three-month campaign aboard a coffin-shaped bus.
Isolated from the Comfrey plant, Allantoin is a popular ingredient in many skincare regimens. According to new research it may increase longevity by mimicking the benefits of calorie restriction.
Calorie restriction is a subject of debate within the longevity community, and on animal models success is variable. However, it remains one of the most proven ways of extending lifespan in many species, and molecules that mimic the effect at the molecular level have also been associated with protective effects — up-regulating repair and stress response mechanisms. One such molecule is resveratrol, which is responsible for the relatively recent red wine hype.
Researchers in Japan have found that human aging may be able to be delayed or even reversed, at least at the most basic level of human cell lines. In the process, the scientists from the University of Tsukuba also found that regulation of two genes is related to how we age.
The new findings challenge one of the current popular theories of aging, that lays the blame for humans’ inevitable downhill slide with mutations that accumulate in our mitochondrial DNA over time. Mitochondrion are sometimes likened to a cellular “furnace” that produces energy through cellular respiration. Damage to the mitochondrial DNA results in changes or mutations in the DNA sequence that build up and are associated with familiar signs of aging like hair loss, osteoporosis and, of course, reduced lifespan.
So goes the theory, at least. But the Tsukuba researchers suggest that something else may be going on within our cells. Their research indicates that the issue may not be that mitochondrial DNA become damaged, but rather that genes get turned “off” or “on” over time. Most intriguing, the team led by Professor Jun-Ichi Hayashi was able to flip the switches on a few genes back to their youthful position, effectively reversing the aging process.