Scientists don’t actually agree on why we age (which I find a little wild), but there are a number of competing theories of aging.
I dug into 4 of the most representative and current. Any ones you’d add?:
Why do we age? Lots of theories have tried to explain the aging process, but the truth is scientists still don’t agree on a single reason.
Long but annotated! Most important here is human data for specific treatments due out starting in May or June. And apparently they had a mouse study where they expected a paper due out already but other groups chimed in to help with more testing so there is a delay.
Liz Parrish, CEO of BioViva Science and patient zero of biological rejuvenation with gene therapies, is interviewed by Zora Benhamou on her fresh podcast “HackMyAge”.
During the conversation, Liz enters deep into the world of gene therapies, either to cure monogenic diseases, multifactorial genetic diseases, or the mother of all diseases: aging itself.
The conversation lasts for one hour and twenty minutes and has no waste. However, to go direct to certain themes use the following time marks:
0:00:00 Zora introduces the podcast: who is Liz Parrish and what the conversation will be about.
Here’s my latest video!
In November 2020, I made a HDL video based on a meta-analysis in ~3.4 million subjects that was published in July 2020. In Dec 2020, a larger study (n=15.8 million subjects) was published-those data are presented in the video, and compared against the meta-analysis.
In addition, I’ve tested my HDL 2 more times since November 2020, so how’s my progress for getting it into the optimal range? Also, I attempt to derive clinical significance by identifying correlations for higher HDL with lower Lp(a) and hs-CRP.
Studies referenced in the video:
High-density lipoprotein cholesterol and all-cause mortality by sex and age: a prospective cohort study among 15.8 million adults:
https://pubmed.ncbi.nlm.nih.gov/33313654/
HDL-C is associated with mortality from all causes, cardiovascular disease and cancer in a J-shaped dose-response fashion: a pooled analysis of 37 prospective cohort studies:
The regeneration of damaged central nervous system (CNS) tissues is one of the biggest goals of regenerative medicine.
Most stroke victims don’t receive treatment fast enough to prevent brain damage. Scientists at The Ohio State University Wexner Medical Center, College of Engineering and College of Medicine have developed technology to “retrain” cells to help repair damaged brain tissue. It’s an advancement that may someday help patients regain speech, cognition and motor function, even when administered days after an ischemic stroke.
Engineering and medical researchers use a process created by Ohio State called tissue nanotransfection (TNT) to introduce genetic material into cells. This allows them to reprogram skin cells to become something different—in this case vascular cells—to help fix damaged brain tissue.
Study findings published online today in the journal Science Advances.
Today at 1 PM PST.
On Sunday, February 212021, at 1 p.m. U.S. Pacific Time, the U.S. Transhumanist Party invites Dr. Aubrey de Grey of the SENS Research Foundation, for an in-depth conversation about recent developments in the quest to reverse the damage of biological aging. The discussion will cover current in rejuvenation research and advocacy, as well as delve into how the prospects for reaching longevity escape velocity have changed since Dr. de Grey’s remarks at the U.S. Transhumanist Party Discussion Panel on Life Extension nearly 4 years ago in 2017.
Dr. Aubrey de Grey is the biomedical gerontologist who researched the idea for and founded SENS Research Foundation — http://www.sens.org/. He received his BA in Computer Science and Ph.D. in Biology from the University of Cambridge in 1985 and 2000, respectively. Dr. de Grey is Editor-in-Chief of Rejuvenation Research, is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organizations.
Watch this Virtual Enlightenment Salon on YouTube here: https://www.youtube.com/watch?v=ohet4kAfskM
I will look at the idea that all disease could be almost stopped in its tracks with a universal treatment for aging. A lot of people ask when we will cure aging and the answer is it may well be here sooner than many realise.
It doesn’t matter how good the treatments are that we develop for cancer, heart disease, alzheimers, and any other of a number of the most common ways we finally die, it is really just a game of whack a mole. If you survive one, just wait a few years and another will get you.
And they cost society, both socially and economically on a massive scale.
Does that sound morbid, sad, as if it is all just pointless?
Well it kind of is, in a way.
But it doesn’t have to be that way…
Biomedical gerontologist Aubrey de Grey, who’s Chief Science Officer of the SENS Research Foundation, is now predicting a 50% chance that people will begin retaining their youthful state via advanced science and technologies by the year 2036.
This is roughly around the same timeline that The Last Generation to Die is based on. Nailed it (hopefully)!
who’s Chief Science Officer of the SENS Research Foundation, is now predicting a 50% chance that people will begin retaining their youthful state via advanced science and technologies by the year 2036.
This is roughly around the same timeline that The Last Generation to Die is based on. Nailed it (hopefully)!
By 2050, the number of adults over the age of 65 globally will double, reaching a staggering 1.6 billion, with the largest growth in the developing world. This growth will be one of the greatest social, economic, and political transformations of our time, that will impact existing healthcare, government and social systems, that today are largely not inclusive of the ageing population or built to the scale needed to support it.
But we can begin to make investments in our support systems (enabled and scaled by technology) that encompass a coordinated response from governments, society, academia, and the private sector.
A precursor to investing in innovative solutions will be to acknowledge the needs of older adults and identify their caregiving challenges. These are the issues that will inform the solutions agenda.
Following in my recent series on subjects that are all the rage in anti-aging and longevity circles, to help you get a good grasp of the essentials so you can know what all the talk is about, and can make informed judgements rather than just following the herd blindly. This time it is on Metformin. This is a drug widely known as a diabetes drug and it has been in use for a very long time, indeed it is one of the most prescribed drugs there is. Recently it has also been a buzz word in the anti aging/longevity communities following the review of data and with it s mechanism of action, being touted and recommended by a variety of voices in the public domain. But how does it work, and how could it improve longevity? Is it safe? Well, if you want to go into a bit more depth and know all the details, I have put together a video which helps you understand what all the fuss is about. And whatever you are doing, have a great day.
Metformin is very popular in the anti aging paradigm currently so let’s have a look at what it is, what it offers, and what the trade offs are… because, well, it is always wise to have all the data.
In this video I will look at the history of metformin and describe its mechanism of action before delving into the current thoughts on its use as an anti aging supplement and longevity benefits due to its overall health benefits.
If you would like to know more about longevity in general as well as the hallmarks of aging then why not check out this video next.
If you would like to look at the articles and studies mentioned they can be found at these links.
