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Category: life extension – Page 233

As we age, our muscles gradually become smaller, weaker and less able to heal after injury. In a new study, UPMC and University of Pittsburgh researchers pinpoint an important mediator of youthfulness in mouse muscle, a discovery that could advance muscle regeneration therapies for older people.

Published today in Nature Aging, the study demonstrates that circulating shuttles called , or EVs, deliver for the longevity protein known as Klotho to cells. Loss of muscle function and impaired muscle repair in old may be driven by aged EVs, which carry fewer copies of these instructions than those in .

The findings are an important advance in understanding why the capacity for muscles to regenerate dwindles with age.

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Combining knowledge of chemistry, physics, biology, and engineering, scientists from McGill University develop a biomaterial tough enough to repair the heart, muscles, and vocal cords, representing a major advance in regenerative medicine.

“People recovering from heart damage often face a long and tricky journey. Healing is challenging because of the constant movement tissues must withstand as the heart beats. The same is true for vocal cords. Until now there was no injectable material strong enough for the job,” says Guangyu Bao, a PhD candidate in the Department of Mechanical Engineering at McGill University.

The team, led by Professor Luc Mongeau and Assistant Professor Jianyu Li, developed a new injectable hydrogel for wound repair. The hydrogel is a type of biomaterial that provides room for cells to live and grow. Once injected into the body, the biomaterial forms a stable, porous structure allowing live cells to grow or pass through to repair the injured organs.

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Due to last years success, I am back with an updated list of my 5 most promising anti-aging compounds.

There are more than 200 different geroprotective compounds. Some of these are already available as supplements, some are in clinical trials and some have FDA approval. Which are my top 5 that I think i most promising in terms of their anti-aging effects (so focusing more on healthspan than lifespan). And note the use of “promising” — there is still much work to be done to better investigate the long-term safety, dose and timings of different supplements which you should always bear in mind.

Anyway, I made this video more for a bit of fun and to make a longer summary video to pull ideas together from multiple previous videos with some new info too! So hope you like it! And disclaimer — this is not recommendation or health advise — i am not a medical doctor!!

Do my top 5 match yours?

Continue reading “5 Most Promising Anti-Aging Compounds (Updated 2022)” | >

Combining knowledge of chemistry, physics, biology, and engineering, scientists from McGill University develop a biomaterial tough enough to repair the heart, muscles, and vocal cords, representing a major advance in regenerative medicine.

“People recovering from heart damage often face a long and tricky journey. Healing is challenging because of the constant movement tissues must withstand as the heart beats. The same is true for vocal cords. Until now there was no injectable material strong enough for the job,” says Guangyu Bao, a PhD candidate in the Department of Mechanical Engineering at McGill University.

Read more | >

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Papers referenced int the video:
Joint distribution of lipoprotein cholesterol classes. The Framingham study.
https://pubmed.ncbi.nlm.nih.gov/6573877/

Long-term coronary heart disease risk associated with very-low-density lipoprotein cholesterol in Chinese: the results of a 15-Year Chinese Multi-Provincial Cohort Study (CMCS)
https://pubmed.ncbi.nlm.nih.gov/20223457/

Red blood cell distribution width and cardiovascular diseases.

Continue reading “How Many Calories Are Optimal For Health?” | >

Engie and Macquarie to build 150MW one hour battery at site of shuttered Hazelwood coal generator.

French energy giant Engie and Macquarie’s Green Investment Group are to jointly fund the construction of a 150MW/150MWh big battery at the site of the now closed Hazelwood brown coal generator.

The announcement, which comes four years after Engie closed what was Australia’s dirtiest power station, continues the trend of using the sites of closed or ageing coal and gas plants to build battery storage to support the switch to 100 per cent renewables.

Construction has already begun on the Hazelwood Battery, which will be built and maintained over a 20-year period by US-based Fluence, using – for the first time in Australia – its sixth-generation Gridstack product and its AI-enabled bidding system.

Continue reading “Engie and Macquarie to fund 150MW big battery at Hazelwood” | >

In this episode, I talk to world-renowned biologist David Sinclair about aging and longevity. David rejects the notion that the deterioration of health is a natural part of growing old and asserts that aging is a disease itself that we need to reverse. But how will a reset of our biological clocks affect our interactions, responses to adversity, morality, and how we live our lives? We discuss the ethical implications of limitless lifespans and also touch on the topics of death, evolution, genetics, medicine, and data tracking.

Bio.
Dr. David Sinclair is a professor in the department of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School and co-founder of the scientific journal Aging. He is best known for his work on understanding why we age and how to slow its effects. In addition to being a co-founder of several biotechnology companies, he’s the author of the book Lifespan: Why We Age – and Why We Don’t Have To. Dr. Sinclair was listed by TIME magazine as one of the “100 most influential people in the world”.

Website: sinclair.hms.harvard.edu.

Twitter: @davidasinclair.

Continue reading “David Sinclair || Why We Age and Why We Don’t Have To” | >