Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: life extension – Page 231

Dr Brian Kennedy — validating aging interventions and why rapamycin is the gold standard

Dr Brian Kennedy explains why verifying longevity interventions work is key and why the transition to human trials is so important.

Brian Kennedy is one of the busiest people in the longevity business, with fingers in many of the most interesting antiaging pies. He was at the Longevity Investors Conference recently, discussing some of the latest discoveries in longevity research and giving a longevity industry overview.

The Longevity Investors Conference (LIC) is the world’s leading and most private longevity-focused investors-only conference. Providing relevant insights into the fast-growing field of longevity, the conference also offers expert education and investment opportunities, as well as fostering excellent networking opportunities. It was our privilege to attend and talk to so many key opinion leaders.

Visit Longevity. Technology — https://bit.ly/3PwtH8Y

Follow Longevity. Technology on:
Twitter — https://bit.ly/3AMIXuq.
Facebook — https://bit.ly/3z8H1v5
Instagram — https://bit.ly/3IDvVRX
Linkedin — https://bit.ly/3yIfDmf

Dr Charles Brenner: longevity is not a simple engineering problem

Dr Charles Brenner on the longevity understanding disconnect, the best interventions for longevity, and the NR trials he’d like to see.

The Longevity Investors Conference is a key event for those interested in learning about longevity investment opportunities and finding out more about the exciting directions in which the field is accelerating. The world’s leading and most private longevity-focused investors-only conference, LIC attracts some of the most prominent thought leaders.

One of those thought leaders is Charles Brenner, the biochemist whose work on nicotinamide adenine dinucleotide (NAD), the central catalyst of metabolism, includes the discovery of nicotinamide riboside (NR) kinase pathway and the resulting tech that led to the development of NR as an NAD-booster.

As Eric Verdin did recently, Brenner is one for driving the longevity debate, even if it causes more than a few ripples, and in cautioning against overstating progress, he is a significant calibration point for our industry (Twitter wars, notwithstanding). We were able to grab a few moments with Brenner at LIC to find out more about his thoughts on the current state of play.

Visit Longevity. Technology — https://bit.ly/3PwtH8Y

Follow Longevity. Technology on:

Continue reading “Dr Charles Brenner: longevity is not a simple engineering problem” | >

The next wave of regenerative medicine

Regenerative medicine company Frequency Therapeutics is developing new drugs that activate our innate abilities to restore function and reverse degenerative diseases. The company is working on small molecules that selectively activate progenitor cells already present within our bodies to create healthy, functional tissues. Frequency’s initial focus is on hearing loss and multiple sclerosis, and the company has just completed enrolment of a Phase 2b trial in adults with acquired sensorineural hearing loss (SNHL).

Longevity. Technology: Frequency is focused on progenitor cells, which are like stem cells but can only make cells that belong to the same tissue or organ. While progenitor cells remain active in some of our organs and tissues, they can become dormant in others. Frequency’s small molecules are designed to selectively target and induce dormant progenitor cells to create specific cell types to restore tissue structure and function. We caught up with Frequency’s Chief Scientific Officer Dr Chris Loose to learn more.

Nasdaq-listed Frequency was founded in 2014, licensing technology developed by professors Robert Langer from MIT and Jeffrey Karp from Harvard Medical School.

Tobias Reichmuth — the longevity market starts now

Dr talks taking hardcore science to market without biotech approval risk and the catalyst that is translational research.

We were lucky enough to attend the Longevity Investors Conference last month; this key event attracts those interested in learning about longevity investment opportunities and finding out more about the exciting directions in which the field is accelerating. To put it succinctly, as MIT Tech Review did recently, LIC “brings academic scientists and biotech companies together with deep-pocketed investors. We’re talking millionaires and billionaires.”

One of the driving forces behind the Longevity Investors Conference is Dr Tobias Reichmuth; a company-builder since the age of 21, Reichmuth has invested in more than 20 startups and is one of the founding partners of Maximon, the longevity company building. Along with his Maximon colleague Marc P Bernegger, Riechmuth launched the Longevity Investors Conference, and we couldn’t pass up the chance to grab some time with him to discuss the current longevity market.

Visit Longevity. Technology — https://bit.ly/3PwtH8Y

Follow Longevity. Technology on:
Twitter — https://bit.ly/3AMIXuq.
Facebook — https://bit.ly/3z8H1v5
Instagram — https://bit.ly/3IDvVRX
Linkedin — https://bit.ly/3yIfDmf

“Unexpected” — Scientists Discover an Anti-Aging Mechanism

A multinational team headed by University College London scientists has discovered a new mechanism that slows down and maybe even prevents the normal aging of immune cells, one of the nine “hallmarks of aging.”

The discovery in-vitro (cells) and validated in mice was “unexpected,” according to the researchers, who believe harnessing the mechanism might extend the life of the immune system, enabling people to live healthier and longer lives, and would also have therapeutic use for diseases such as cancer and dementia. Their findings were recently published in the journal Nature Cell Biology.

Explaining the study, lead author, Dr. Alessio Lanna, Honorary Professor at UCL Division of Medicine, said: Immune cells are on constant high-alert, always ready to fight pathogens. To be effective they also must persist for decades in the body – but the strategies employed to execute this life-long protection are largely unknown.

Aubrey de Grey on longevity at scale

New foundation aims for scientific and rhetorical value – and to run the debug cycle for longevity research.

The Longevity Investors Conference is quickly turning into one of the highlights in the longevity calendar, and we were delighted to be able to interview some of the speakers in a few ‘backstage’ moments.

Held in the exclusive location of Gstaad in Switzerland, The Longevity Investors Conference (LIC) is the world’s leading and most private longevity-focused investors-only conference. Providing relevant insights into the fast-growing field of longevity, the conference also offers expert education and investment opportunities, as well as fostering excellent networking opportunities. Dr Aubrey de Grey was in Gstaad to address the conference on rejuvenation biotechnology as well as being part of a panel discussing where crypto meets longevity.

Visit Longevity. Technology — https://bit.ly/3PwtH8Y

Follow Longevity. Technology on:
Twitter — https://bit.ly/3AMIXuq.
Facebook — https://bit.ly/3z8H1v5
Instagram — https://bit.ly/3IDvVRX
Linkedin — https://bit.ly/3yIfDmf

H+ Academy Roundtable Features Dr. Michael Rose

Dr. Michael Rose is an evolutionary biologist and authority in gerontology. His many years of research and keen insight establish unique methods to frame the problems of aging. Michael made scientific history with experiments manipulating the life spans of fruit flies. As a pragmatist, Michael sees beyond today’s quick fixes to examine what could be the most important changes in the longevity industry to slow down and stop aging. His view is that genomics in conjunction with machine learning is the future of longevity.

Immortality trailer (PC Gaming Show 2022)

The latest trailer for Immortality, a narrative FMV game from Sam Barlow, creator of Her Story. Immortality releases July 26 on Game Pass, Steam, and GOG.

Catch everything that was revealed at the PC Gaming Show: https://www.pcgamer.com/how-to-watch-pc-gaming-show-2022/

#PCGamingShow2022 #gaming #pc.

Twitter: twitter.com/PCGamer.
Instagram: @pcgamer_mag.
Facebook: facebook.com/pcgamermagazine.
Forum: forums.pcgamer.com.

To subscribe to the magazine in the US, UK, or elsewhere, visit myfavouritemagazines.co.uk.

PC Gamer is the global authority on PC games. We’ve been covering PC gaming for more than 20 years, and continue that legacy today with worldwide print editions and around-the-clock news, features, esports coverage, hardware testing and game reviews on PCGamer.com, as well as major yearly events including the PC Gaming Show at E3.

Continue reading “Immortality trailer (PC Gaming Show 2022)” | >

Dr. Jacob Hanna, MD, Ph.D. — Synthetic Embryo R&D In Regenerative Medicine & Developmental Biology

(https://hannalabweb.weizmann.ac.il/) is a Senior Scientist and Professor in the Department of Molecular Genetics at the Weizmann Institute of Science in Israel, where his lab, and the interdisciplinary group of scientists within it, are focused on understanding the complexity of early embryonic stem cell biology and early developmental dynamics, as well as advancing human disease modeling.

More specifically, Dr. Hanna’s lab investigates the detailed process of cellular reprogramming, in which induced pluripotent stem cells are generated from somatic cells, and they investigate how pluripotency is maintained throughout development in mouse and human. In their studies they employ a diverse arsenal of biological experimentation methods, high throughput screening, advanced microscopy and genomic analyses seeking to combine biological experimentation with computational biology, theory and modeling, to elucidate various biological questions.

Dr. Hanna completed both his MD and PhD at The Hebrew University of Jerusalem, where his work was focused in the domain of immunology with his thesis focus on novel molecular and functional properties of human NK Subsets. He then went on to do postdoctoral studies at the Whitehead Institute for Biomedical Research at MIT under the tutelage of Prof. Dr. Rudolf Jaenisch with a field of study of pluripotency and epigenetic reprogramming.

Dr. Hanna is also Founder and Chief Scientific Advisor, of Renewal Bio (https://www.renewal.bio/), a biotech company looking to leverage the power of these new stem cell technologies, potentially applying them to a wide variety of human ailments including infertility, genetic diseases, and longevity.

Sites in the brain where RNA is edited could help our understanding of neurodevelopment and disease

Mount Sinai researchers have cataloged thousands of sites in the brain where RNA is modified throughout the human lifespan in a process known as adenosine-to-inosine (A-to-I) editing, offering important new avenues for understanding the cellular and molecular mechanisms of brain development and how they factor into both health and disease.

In a study published in Cell Reports, the team described how the rate of RNA editing in the brain increases as individuals age, with implications for dissecting the pathology of altered A-to-I editing across a range of neurodevelopmental and aging disorders.

“Our work provides more nuanced and accurate insights into the contribution of RNA modifications by A-to-I editing during human brain development,” says senior author Michael Breen, Ph.D., Assistant Professor of Psychiatry, and Genetics and Genomic Sciences, at the Icahn School of Medicine at Mount Sinai, and a member of the Seaver Center for Autism Research and Treatment.

/* */