So much here I never knew:

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Dr. Axel Montagne is a chancellor’s fellow and group leader at the UK Dementia Research Institute at the University of Edinburgh Centre for Clinical Brain Sciences. His group aims to understand how, when, and where critical components of the blood-brain barrier become dysfunctional preceding dementia and in the earliest stages of age-related cognitive decline. With this knowledge, they hope to develop precise treatments targeting brain vasculature to protect brain function.

More importantly his work, and that of his colleagues, provide a critical lens through which to view the contributions of vascular dysfunction (or, conversely, vascular health – if we choose to preserve it) as a critical common thread in dementia and neurodegeneration.

EPISODE LINKS:
Show notes and transcript: https://www.foundmyfitness.com/episodes/axel-montagne.
Montagne lab website: https://montagnelab.com/
Axel Montagne — Google Scholar: https://scholar.google.com/citations?user=dRTfpRoAAAAJ
Twitter: @AxL_Montagne: https://twitter.com/AxL_Montagne.

PODCAST INFO:

Aging is a complex process, a river fed by several tributaries connected by countless interweaving streams. Its direction is set inexorably towards infirmity, or so it would first appear. Daunting as navigation may seem, their interrelatedness should inspire hope instead of fear.

Aging is undeniably the root of the most common and costly noncommunicable diseases in the developed world, as well as a predisposing factor to severe or fatal reactions to infectious ones. Whatever can be done to slow, halt, or reverse its course holds inestimable economic and humanitarian value (Lee, 2017).

The hallmarks of aging were assembled to broadly conceptualize what lies behind phenomena as seemingly unrelated as gray hair, wrinkles, heart disease, cognitive decline, and cancer. They serve as explanations for why everything from our joints to our eyesight steadily give out over time.

“People on metformin have 30% lower rates of almost every kind of cancer. It delays cognitive decline. Even people with diabetes who are obese and have more disease to start with but are on metformin have lower mortality rates than people without diabetes who aren’t on the drug.”

What he says is born out in numerous studies. Overall, this safe, super-cheap, decades-old drug not only treats diabetes, but it also seems to delay and compress the years of chronic illness associated with the final stage of life and extend what geroscientists call the “healthspan.”

Metformin is just one of many medications, including other old ones and some brand new inventions, that academic researchers and biotech startups are exploring to slow, stop, or perhaps even reverse aging.

For the first time, a researcher at the University of Delaware College of Health Sciences in collaboration with a team at the National Institute on Aging, a division of the National Institutes of Health, has determined that the naturally occurring dietary supplement known as nicotinamide riboside (NR) can enter the brain.

The discovery was made by Christopher Martens, assistant professor of kinesiology and applied physiology and director of the Delaware Center for Cognitive Aging Research, and Dr. Dimitrios Kapogiannis, a senior investigator at the National Institute on Aging. The finding is significant because it supports the idea that NR, upon reaching the brain, can alter the metabolism of relevant biological pathways involved in neurodegenerative diseases like Alzheimer’s. Their work was recently published in the journal Aging Cell.

Upon consumption, NR is readily converted into nicotinamide adenine dinucleotide (NAD+), which is critical to cellular repair and the repair of damaged DNA.