Summary: Better glucose uptake compensates for age-related motor deterioration and extends lifespan in fruitflies.
Source: Tokyo Metropolitan University.
Researchers from Tokyo Metropolitan University have discovered that fruit flies with genetic modifications to enhance glucose uptake have significantly longer lifespans.
No that’s not clickbait.
Being able to stop and reverse aging is probably something every single person has yearned for at some point in their life. Now researchers are finally seeing successful implementations of methods for reversing aging in Animal cells. This creates the potential for countless benefits for humans. These range from simply preventing age related illness all the way to allowing women the opportunity to have kids at any point in their life when they are ready. We are living in very exciting scientific times.
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Researchers from Tokyo Metropolitan University have discovered that fruit flies with genetic modifications to enhance glucose uptake have significantly longer lifespans. Looking at the brain cells of aging flies, they found that better glucose uptake compensates for age-related deterioration in motor functions, and led to longer life. The effect was more pronounced when coupled with dietary restrictions. This suggests healthier eating plus improved glucose uptake in the brain might lead to enhanced lifespans.
The brain is a particularly power-hungry part of our bodies, consuming 20% of the oxygen we take in and 25% of the glucose. That’s why it’s so important that it can stay powered, using the glucose to produce adenosine triphosphate (ATP), the “energy courier” of the body. This chemical process, known as glycolysis, happens in both the intracellular fluid and a part of cells known as the mitochondria. But as we get older, our brain cells become less adept at making ATP, something that broadly correlates with less glucose availability. That might suggest that more food for more glucose might actually be a good thing. On the other hand, it is known that a healthier diet actually leads to longer life. Unraveling the mystery surrounding these two contradictory pieces of knowledge might lead to a better understanding of healthier, longer lifespans.
A team led by Associate Professor Kanae Ando studied this problem using Drosophila fruit flies. Firstly, they confirmed that brain cells in older flies tended to have lower levels of ATP, and lower uptake of glucose. They specifically tied this down to lower amounts of the enzymes needed for glycolysis. To counteract this effect, they genetically modified flies to produce more of a glucose-transporting protein called hGut3. Amazingly, this increase in glucose uptake was all that was required to significantly improve the amount of ATP in cells. More specifically, they found that more hGut3 led to less decrease in the production of the enzymes, counteracting the decline with age. Though this did not lead to an improvement in age-related damage to mitochondria, they also suffered less deterioration in locomotor functions.
I’m curious what biomarkers people here currently track? I did some research and came up with these 20 but any you would add/take away? (9 of them were mostly included to be able to use Morgan Levine’s biological age calculator).
This is the first article in a two-part series on the best aging biomarkers to track for longevity. The second article will compare different tests and testing companies on the market and supply a sample testing schedule you can use.
Continue reading “20 Best Aging Biomarkers to Track for Longevity” »
A breakthrough skin-gel is showing promising signs in Australian trials, with the ability to halt chronic pain in its tracks, halve healing time and even turn back the clock on ageing skin.
The gel, which is known as RM191A, is believed to be a new class of anti-inflammatory.
It’s a copper-based compound which is applied directly to the skin as a topical.
Important here is at 38:13 where he says not only is his TAME trial paid for but an organization is going to pay a billion dollars per year on aging. He was not allowed to give details but it was going to start this month. I’ll be watching for the news.
Zoom Transcription: https://otter.ai/u/vTb6HEbcyTXBPgVrgRzB3I0CDC8
Continue reading “TAME & Biomarker Q&A with Nir Barzilai, Institute for Aging Research” »
This last year has been not been one for the social calendar. It has left us all feeling more and more isolated with lockdown after lockdown and restricted travel options globally. It is something we need to actively work to overcome, for our own sakes and for those around us, it is as detrimental to our long term health as smoking, obesity or having an alcohol disorder. It increases the risk of many health conditions, and even alters gene expressions. If you want to know even more detail I break it down in this new video, and look out for those who are having a rougher time, pay it forward. Make this world a place you want to live in…
In Loneliness As Deadly As Smoking-How It Impacts Your Health & Longevity I will be talking about how social isolation, something becoming more and more apparent in many countries and cities across the globe, is a serious threat to health and longevity.
Continue reading “Loneliness As Deadly As Smoking — How It Impacts Your Health & Longevity” »
Elon Musk’s Neuralink showcases working implanted brain computer and promises future health benefits.
Elon Musk company Neuralink has been researching how directly interfacing with the brain could be used as therapy for chronic and debilitating medical conditions, as well as exploring how technological augmentation could expand and develop the capabilities of the human brain.
Continue reading “Neuralink reveals the ‘Fitbit for your brain’” »
HURRY. I’m getting old.
Recent advances in deep learning enabled the development of AI systems that outperform humans in many tasks and have started to empower scientists and physicians with new tools. In this Comment, we discuss how recent applications of AI to aging research are leading to the emergence of the field of longevity medicine.
