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Talk kindly contributed by Michael Levin in SEMF’s 2022 Spacious Spatiality.

https://semf.org.es/spatiality.

TALK ABSTRACT
Life was solving problems in metabolic, genetic, physiological, and anatomical spaces long before brains and nervous systems appeared. In this talk, I will describe remarkable capabilities of cell groups as they create, repair, and remodel complex anatomies. Anatomical homeostasis reveals that groups of cells are collective intelligences; their cognitive medium is the same as that of the human mind: electrical signals propagating in cell networks. I will explain non-neural bioelectricity and the tools we use to track the basal cognition of cells and tissues and control their function for applications in regenerative medicine. I will conclude with a discussion of our framework based on evolutionary scaling of intelligence by pivoting conserved mechanisms that allow agents, whether designed or evolved, to navigate complex problem spaces.

TALK MATERIALS
· The Electrical Blueprints that Orchestrate Life (TED Talk): https://www.ted.com/talks/michael_levin_the_electrical_bluep…trate_life.
· Michael Levin’s interviews and presentations: https://ase.tufts.edu/biology/labs/levin/presentations/
· Michael Levin’s publications: https://ase.tufts.edu/biology/labs/levin/publications/
· The Institute for Computationally Designed Organisms (ICDO): https://icdorgs.org/

MICHAEL LEVIN
Department of Biology, Tufts University: https://as.tufts.edu/biology.
Tufts University profile: https://ase.tufts.edu/biology/labs/levin/
Wyss Institute profile: https://wyss.harvard.edu/team/associate-faculty/michael-levin-ph-d/
Wikipedia: https://en.wikipedia.org/wiki/Michael_Levin_(biologist)
Google Scholar: https://scholar.google.com/citations?user=luouyakAAAAJ
Twitter: https://twitter.com/drmichaellevin.
LinkedIn: https://www.linkedin.com/in/michael-levin-b0983a6/

SEMF NETWORKS

Summary: Probiotics might play a vital role in preventing cognitive decline associated with aging. By providing participants suffering from mild cognitive impairment with the probiotic Lactobacillus rhamnosus GG for three months, researchers observed enhanced cognitive performance and gut microbiome modifications.

The study suggests that altering gut microbiome might be a strategic approach to enhancing cognitive function in individuals with mild cognitive impairment. If replicated, these findings could revolutionize preventive strategies in cognitive health using gut microbiome-focused approaches.

A healthy immune system: the ultimate balancing act

The immune system is comprised of innate and adaptive immune responses, both of which are crucial in maintaining our health. The innate immune response is the first line of defense that immediately works to prevent the spread of pathogens and tumors.1 The adaptive immune response is a more sophisticated, secondary response that is specialized to clear specific pathogens and provide long-lasting immunity.2

The efficacy of these two systems depends on balanced inflammatory and anti-inflammatory responses, referred to as immunomodulation. For example, upon injury or infection, macrophages secrete molecules that promote inflammation to dilate blood vessels and recruit other immune cells to the damaged site. Once the infection is cleared, the immune system mounts an anti-inflammatory, reparatory response.

Recent research published in Nature Communications has used machine learning algorithms to find new compounds that can eliminate senescent cells [1].

Senolytics are molecules that destroy senescent cells. Only a small number of such molecules have been identified, and only two have shown efficacy in clinical trials: dasatinib and quercetin in combination [2]. One of the biggest challenges is that senolytics often only work against specific types of cells. Additionally, some senolytics may work well for one cell type while being toxic to other, non-senescent cell types [3].

There is also a group of senolytics that are used in cancer therapies. However, most of them target pathways that are mutated in cancer. Therefore, they cannot be used as therapeutic agents in different contexts.

Age is a risk factor for hematologic malignancies. Attributes of the aging hematopoietic system include increased myelopoiesis, impaired adaptive immunity, and a functional decline of the hematopoietic stem cells (HSCs) that maintain hematopoiesis. Changes in the composition of diverse HSC subsets have been suggested to be responsible for age-related alterations, however, the underlying regulatory mechanisms are incompletely understood in the context of HSC heterogeneity. In this study, we investigated how distinct HSC subsets, separated by CD49b, functionally and molecularly change their behavior with age. We demonstrate that blood lineage differentiation progressively shifts to a higher myeloid cellular output in both lymphoid-biased and myeloid-biased HSC subsets during aging. In parallel, we show that HSCs selectively undergo age-dependent gene expression and gene regulatory molecular changes in a progressive manner, which is initiated already in the pre-adult stage. Overall, our studies suggest that aging intrinsically alters both cellular and molecular properties of HSCs.

The authors have declared no competing interest.