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Category: life extension – Page 132

How to Defeat Aging? Two Scientists Offer Their Visions

In a much-anticipated debate, prominent aging researchers Aubrey de Grey and Peter Fedichev presented their competing, but also overlapping, theories.

When the non-profits Foresight Institute, Open Longevity, and Say Forever had the idea to hold debates on the best strategy to defeat aging, there was little question about whom they should invite first. Aubrey de Grey, head of LEV Foundation and one of the faces of the longevity field, and Peter Fedichev, CEO of Gero and a rising star in the same field, already had an impromptu debate last year in Zuzalu, the longevity/crypto/AI-themed pop-up city in Montenegro. I had the honor to witness that clash of titans, which kept a small but dedicated crowd on its toes for more than two hours.

The impromptu debate in Zuzalu. Photo: Arkadi Mazin.

Targeted Covalent Inhibition of Telomerase

I think this could lead to immortality basically allowing for limited growth of dna structures but still offering unlimited lifespan. In short this also prevents cancer aswell.

Telomerase is a ribonuceloprotein complex responsible for maintaining telomeres and protecting chromosomal integrity. The human telomerase reverse transcriptase (hTERT) is expressed in ∼90% of cancer cells where it confers the capacity for limitless proliferation. Along with its established role in telomere lengthening, telomerase also serves noncanonical extra-telomeric roles in oncogenic signaling, resistance to apoptosis, and enhanced DNA damage response. We report a new class of natural-product-inspired covalent inhibitors of telomerase that target the catalytic active site.

Nicotine rebalances NAD+ homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity

This also an amazing supplement that also exists in all foods called nad plus that stops age related symptoms.

Nicotine, a metabolite of the NAD+ metabolic pathway, has been found to possess anti-inflammatory and neuroprotective properties, yet the underlying molecular mechanisms remained unknown. Here, the authors show that low-dose nicotine promotes SIRT1 deacetylation of NAMPT and enhanced NAMPT activity which boosts NAD generation and improves age related symptoms.

Comparative genomics of mortal and immortal cnidarians unveils novel keys behind rejuvenation

Though hardly conclusive, this study strongly suggests that boosting NAD+ levels in humans could have incredible health benefits.

That’s where Basis comes in.

Created by Elysium Health, Basis is a proprietary formulation of crystalline nicotinamide riboside and pterostilbene, which the human body converts into NAD+. In a double-blind, randomized, placebo-controlled clinical trial, it was demonstrated that, on average, Basis increases NAD+ levels by 40 percent. These elevated NAD+ levels won’t necessarily stop the aging process. But they will certainly maximize cellular health, boost energy, and support healthy sleep. This in turn should allow people who are in good health to maintain it longer, and thus age better.

Biohacker who is ‘reverse aging’ reveals $20k medical procedure that ‘edits his DNA’ so he ‘lives forever’

He added: “Their target: follistatin gene therapy. A pioneering technology with the potential to improve muscle and strength [and] slow the speed of aging and many more benefits.”

The millionaire explained that the procedure involves an injection in the stomach and in the buttocks.

It also costs $20,000, so not exactly cheap.

Are Children The Future?: Longtermism, Pronatalism, and Epistemic Discounting

From the article:

Longtermism asks fundamental questions and promotes the kind of consequentialism that should guide public policy.

Based on a talk delivered at the conference on Existential Threats and Other Disasters: How Should We Address Them? May 30–31, 2024 – Budva, Montenegro – sponsored by the Center for the Study of Bioethics, The Hastings Center, and The Oxford Uehiro Center for Practical Ethics.

For twenty years, I have been talking about old age dependency ratios as an argument for universal basic income and investing in anti-aging therapies to keep elders healthy longer. A declining number of young workers supporting a growing number of retirees is straining many welfare systems. Healthy seniors are less expensive and work longer. UBI is more intergenerationally equitable, especially if we face technological unemployment.

But as a person anticipating grandchildren, I think the declining fertility part of the demographic shift is more on my mind. It’s apparently on the minds of a growing number of people, including folks on the Right, ranging from those worried that feminists are pushing humanity to suicide or that there won’t be enough of their kind of people in the future to those worried about the health of innovation and the economy. The reluctance by the Left to entertain any pronatalism is understandable, given the reactionary ways it has been promoted. But I believe a progressive pro-family agenda is possible.

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