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The Coming Age for Tech x Bio: The ‘Industrial Bio Complex’

Driving this revolution has been a new breed and wave of founders and startups that merge the worlds of technology and bio — importantly, not just the old world of biotech (or a narrow definition of tech in bio as only “digital health”), but something much broader, bigger, and blending both worlds. In short, biology — enabled by technology — is eating the world. This has not only changed how we diagnose, treat, and manage disease, but has been changing the way we access, pay for, and deliver care in the healthcare system. It is now entering into manufacturing, food, and several other industries as well. Bio is becoming a part of everything.

This new era of industrialized bio — enabled by AI as well as an ongoing, foundational shift in biology from empirical science to more engineered approaches — will be the next industrial revolution in human history. And propelling it forward is an enormous new driving force, the novel coronavirus SARS-CoV-2, its ever-evolving strains, and the resulting COVID-19 disease pandemic and response — which I believe is analogous to our generation’s World War II (WW2). In other words: a massive global upheaval, but that later led to unprecedented innovation and significant new players.

As a result, we will now see the emergence of bio’s version of GAFA — playing off the “Google Amazon Facebook Apple” of the leading companies in computing, social, mobile — but for bio. And with it, a post-WW2/ post-Covid “Industrial Bio Complex”.

First new treatment for sickle cell in 20 years

Sickle-cell disease is incurable and affects 15,000 people in the UK.

And the National Institute for Health and Care Excellence said the hope of reducing health inequalities for black people, who are predominantly affected and often have poorer health to start with, made the drug worth recommending.

It called it “an innovative treatment”.


The hope of reducing health inequalities for black people made it worth recommending, the regulator says.

The Medical Minute: Real-time tumor tracking improves cancer cure rates

Image-guided radiation therapy has evolved to include the ability to track tumors in real time during treatment. It’s improving cure rates and limiting side effects for a growing number of cancer patients.

Think of it like radio making way for television. For more than a century, radiation therapy has been effective in treating cancer. From the first X-rays, to today’s computed tomography (CT) scans, physicians have relied on various imaging techniques to locate tumors and guide their treatment. Enter real-time tumor tracking.

“Magnetic Resonance-guided therapy is really a new paradigm,” said Dr. Rodney Ellis, chair of the Department of Radiation Oncology at Penn State Health Milton S. Hershey Medical Center. He notes the leading-edge technology merges MRI (Magnetic Resonance Imaging) with a linear accelerator, making it possible to reshape radiation dosage based on daily changes in a tumor’s shape, size and position and its surrounding healthy anatomy.

Deleted coronavirus genome sequences trigger scientific intrigue

Efforts to study the early stages of the coronavirus pandemic have received help from a surprising source. A biologist in the United States has ‘excavated’ partial SARS-CoV-2 genome sequences from the beginnings of the pandemic’s probable epicentre in Wuhan, China, that were deposited — but later removed — from a US government database.

The partial genome sequences address an evolutionary conundrum about the early genetic diversity of the coronavirus SARS-CoV-2, although scientists emphasize that they do not shed light on its origins. Nor is it fully clear why researchers at Wuhan University asked for the sequences to be removed from the Sequence Read Archive (SRA), a repository for raw sequencing data maintained by the National Center for Biotechnology Information (NCBI), part of the US National Institutes of Health (NIH).


Partial SARS-CoV-2 sequences from early outbreaks in Wuhan were removed from a US government database by the scientists who deposited them.

Kimberly A Reed — Fmr EXIM Chairman / President — Stimulating STEM & Securing U.S. High-Tech Economy

Stimulating STEM Innovation & Securing U.S. High-Tech Economy — Kimberly A. Reed, Fmr President and Chairman Export-Import Bank of the United States.


Kimberly A. Reed just finished up a 2-year term as President and Chairman of the Board of Directors of the Export-Import Bank of the United States (EXIM — https://www.exim.gov). She was the first woman to lead EXIM in the agency’s 87-year history, was the first recipient of EXIM’s highest honor, the Franklin D. Roosevelt Award, and was confirmed by the U.S. Senate in 2019 on a strong bi-partisan basis.

EXIM provides loans, guarantees, and export credit insurance for the export of U.S. goods and services from enterprises ranging from Fortune 100 companies to small businesses in a multitude of sectors including infrastructure, power, agriculture, transportation/aviation, health care, commodities, industrial, and technology.

Ms. Reed was recognized for successfully navigating Congress to re-open EXIM after four years of dormancy and transforming the mission and impact of the 515-person independent federal agency.

Ms. Reed also spearheaded EXIM’s historic, longest-ever Congressional re-authorization of seven years and a significant new mandate, the Program on China and Transformational Exports, which focuses on industries including biomedical sciences, biotechnology, wireless communication (5G), renewable energy, financial technologies, artificial intelligence, and the space industry.

The race for Israel’s homegrown COVID-19 vaccine

#Israel is on the verge of finalizing a #COVID19 vaccine whose creators believe could offer better protection against variants than its international counterparts such as #Pfizer. In an interview with ‘The Jerusalem Post’, the father of Israel’s BriLife coronavirus vaccine, Prof. Shmuel Shapira, predicted that when the country’s #vaccine is ready, “it will be better” than what its citizens have today.


HEALTH AFFAIRS: The father of the BriLife initiative explains Israel’s strategic imperative to have its own vaccine.

The durability of immunity against reinfection

The timeframe for reinfection is fundamental to numerous aspects of public health decision making. As the COVID-19 pandemic continues, reinfection is likely to become increasingly common. Maintaining public health measures that curb transmission—including among individuals who were previously infected with SARS-CoV-2—coupled with persistent efforts to accelerate vaccination worldwide is critical to the prevention of COVID-19 morbidity and mortality.

US National Science Foundation.

United Health Centers reportedly compromised

A ransomware gang called Vice Society claims it grabbed confidential data such as patient benefits, financial documents and lab results.

Another health care provider has apparently been the victim of a ransomware attack that exposed private patient information and other sensitive data. A ransomware group known as Vice Society has claimed responsibility for an August attack against United Health Centers that allegedly impacted all of its locations. The incident reportedly led to the theft of patient data and forced the organization to shut down its entire network, BleepingComputer reported on Friday.

Radiation to the heart corrects arrhythmia

Scientists at the Washington University School of Medicine have made an intriguing discovery that could see radiation therapy become a less invasive treatment for heart arrhythmia. The technique seems to activate the heart cells to revert to a younger state and repair the tissue.

Arrhythmia is a condition where the heart beats in an irregular fashion, which can lead to potentially dangerous health problems. It’s a result of issues with the way electrical signals are sent through the tissue, and one of the main treatments is called catheter ablation. This invasive procedure involves threading thin tubes through arteries into the heart, making a small burn to create scar tissue that interrupts the signals.

A few years ago, the Washington University team discovered a far less invasive alternative – radiation therapy, of the kind often used to treat cancer patients. When directed at the heart, the treatment was found to improve arrhythmia symptoms, just as well as, or perhaps even better than, catheter ablation.

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