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Category: health – Page 231

Cancer evolution is mathematical

Cancer is not a uniform disease. Rather, cancer is a disease of phenotypic plasticity, meaning tumor cells can change from one form or function to another. This includes reverting to less mature states and losing their normal function, which can result in treatment resistance, or changing their cell type altogether, which facilitates metastasis.

In addition to direct changes in your DNA in cancer, a key driver of cancer progression is where and when your DNA is activated. If your DNA contains the “words” that spell out individual genes, then epigenetics is the “grammar” of your genome, telling those genes whether they should be turned on or off in a given tissue. Even though all tissues in the body have almost exactly the same DNA sequence, they can all carry out different functions because of chemical and structural modifications that change which genes are activated and how. This “epigenome” can be influenced by environmental exposures such as diet, adding a dimension to how researchers understand drivers of health beyond the DNA code inherited from your parents.

I’m a cancer researcher, and my laboratory at Johns Hopkins University studies how the differences among normal tissues are controlled by an epigenetic code, and how this code is disrupted in cancer. In our recently published review, colleague Andre Levchenko at Yale University and I describe a new approach to understanding cancer plasticity by combining epigenetics with mathematics. Specifically, we propose how the concept of stochasticity can shed light on why cancers metastasize and become resistant to treatments.

Testing shows people generate more respiratory aerosols during endurance exercise than resistance exercise

A team of biology researchers from Universität der Bundeswehr, Technische Universität München and the University of Cassino and Southern Lazio, has found that people exhale more aerosols when engaging in endurance exercise than they do when engaging in resistance exercise. The study is published in the Proceedings of the National Academy of Sciences.

As the global pandemic has progressed, scientists across the globe have studied various aspects of the SARS-CoV-2 virus spread. One such area of study has been comparison of types of activities that are more or less conducive to transmission of the .

In this new study, the researchers looked at exercise options and their related risk. Going to gyms to exercise is a popular way to keep in shape. But doing so can put people at risk from both airborne and surface viral and bacterial infections.

For the first time, researchers record long-term electrical activity in a single brain cell

When a person experiences a happy or sad mood, which brain cells are active?

To answer that question, scientists need to understand how individual brain cells contribute to a larger network of brain activity and what role each cell plays in shaping behavior and overall health. Until now, it’s been difficult to get a clear view of how in living animals behave over extended periods of time.

But Jia Liu’s group at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) has developed an electronic implant that collected detailed information about brain activity from a single cell of interest for more than a year. Their findings, based on research in mice, are reported in Nature Neuroscience.

Psyllium fiber protects against colitis

Psyllium fiber protects against ulcerative colitis and suppresses inflammation by activating the bile acid nuclear receptor, a mechanism that was previously unrecognized, according to a new study by researchers in the Institute for Biomedical Sciences at Georgia State University.

The findings published in the journal Cellular and Molecular Gastroenterology and Hepatology (CMGH) reveal that psyllium, which is semi-soluble and derived from Plantago seeds, inhibits inflammation that can lead to colitis in mice by increasing serum bile acids, resulting in the activation of the farnesoid X receptor (FXR), a bile acid nuclear receptor.

Fiber-rich foods promote intestinal and metabolic health, but the extent of protection varies for each fiber type and the mechanisms that offer this protection are poorly defined. It has been unclear whether can benefit severe forms of intestinal inflammation, such as Crohn’s disease and ulcerative colitis, which are collectively known as (IBD) and affect 3 million adults in the United States.

Science On Why Banana Leaves Have Been a Part of Indian Food For Centuries

Whether it is steamed idli, Gujarati snack, panki; Parsi’s patra ni machchi, Assam’s bhapot diya maach or the elaborate Onam Sandhya from Kerala, the humble banana leaf has found its way into many cuisines.

It is also very versatile as food can be steamed, grilled and deep-fried. It can also be used as a serving plate and packaging material.

While banana leaves have been an integral part of the desi food and traditions, did you know there are health benefits to it as well?

Can I Prevent Dementia?

Step one for uploading your brain after the singularity… keep it cognitively functional until then.

It’s been estimated that one in three cases of dementia is preventable. You can’t do anything right now to stop or reverse the underlying mechanisms of Alzheimer’s disease, but you can do something about hypertension and vascular disease risk factors.

#dementia #alzheimer #doctor #healthylifestyle #health #intermittentfasting

‘Electronic nose’ built with sustainably sourced microbial nanowires could revolutionize health monitoring

Scientists at the University of Massachusetts Amherst recently announced the invention of a nanowire, 10,000 times thinner than a human hair, which can be cheaply grown by common bacteria and can be tuned to “smell” a vast array of chemical tracers—including those given off by people afflicted with different medical conditions, such as asthma and kidney disease.

Thousands of these specially tuned wires, each sniffing out a different chemical, can be layered onto tiny, , allowing health-care providers an unprecedented tool for monitoring potential health complications. Since these wires are grown by bacteria, they are organic, biodegradable and far greener than any inorganic nanowire.

To make these breakthroughs, which were detailed in the journal Biosensors and Bioelectrics, senior authors Derek Lovley, Distinguished Professor of Microbiology at UMass Amherst, and Jun Yao, professor of electrical and computer engineering in the College of Engineering at UMass Amherst, needed to look no farther than their own noses.

Developing fabrics that change shape when they heat up

New textiles developed at Aalto University change shape when they heat up, giving designers a wide range of new options. In addition to offering adjustable esthetics, responsive smart fabrics could also help monitor people’s health, improve thermal insulation, and provide new tools for managing room acoustics and interior design.

The new fabrics weave together old technology and a new approach. Liquid crystalline elastomers (LCEs) were developed in the 1980s. LCEs are a smart material that can respond to heat, light, or other stimuli, and they’ve been used as thin films in soft robotics. Although LCEs have been made into fibers, so far they haven’t been made into textiles.

In collaboration with researchers at the University of Cambridge, a team from the Multifunctional Materials Design research group at Aalto, led by Prof. Jaana Vapaavuori, has now used LCE yarns to make woven fabric using conventional crafting techniques and tested how the fabric behaved. The findings were published in Advanced Materials.

Dr. Abdelali Haoudi, PhD — KAIMRC — Advancing Biomedical R&D & Clinical Development In Saudi Arabia

Advancing Biomedical R&D & Clinical Development In Saudi Arabia — Dr. Abdelali Haoudi, Ph.D., Managing Director, Biotechnology Park, King Abdullah International Medical Research Center, Ministry of National Guard Health Affairs.

Dr. Abdelali Haoudi, Ph.D. (https://kaimrc-biotech.org.sa/dr-abdelali-haoudi/) currently leads Strategy and Business Development functions, and is also Managing Director of the Biotechnology Park, at King Abdullah International Medical Research Center, at the Ministry of National Guard Health Affairs. He is also Distinguished Scholar at Harvard University-Boston Children’s Hospital.

Dr. Haoudi is an international Research & Development and Innovation Executive with over 25 years experience, having held several senior positions in Research and Development and Innovation. He has vast experience in science and technology policy development, strategy and business development, corporate development and international partnerships development.

Dr. Haoudi has held several senior and prestigious positions in the academia, government and private sectors globally, including North America, North Africa, Europe and Middle East. Some of the key positions include Founding Vice President for Research, Executive Director for Biomedical Research Institute, and Chairman, at the National Research Fund at Qatar Foundation.

Dr. Haoudi was also Research Professor of cancer and infectious diseases at the University of Virginia and Eastern Virginia Medical School and a fellow of the US National Institutes of Health (NIH). He has held several other positions in elite research and education institutions including Visiting Professor at Harvard Medical School (USA) and a fellow at Institute Pasteur (France).

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