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Archive for the ‘genetics’ category: Page 70

Nov 20, 2023

New study reveals the genetics of human head shape

Posted by in categories: biotech/medical, genetics, neuroscience

Researchers at the University of Pittsburgh and KU Leuven have discovered a suite of genes that influence head shape in humans. These findings, published this week in Nature Communications, help explain the diversity of human head shapes and may also offer important clues about the genetic basis of conditions that affect the skull, such as craniosynostosis.

By analyzing measurements of the cranial —the part of the skull that forms the rounded top of the head and protects the brain—the team identified 30 regions of the genome associated with different aspects of head , 29 of which have not been reported previously.

“Anthropologists have speculated and debated the genetics of cranial vault shape since the early 20th century,” said co-senior author Seth Weinberg, Ph.D., professor of oral and craniofacial sciences in the Pitt School of Dental Medicine and co-director of the Center for Craniofacial and Dental Genetics.

Nov 18, 2023

Scientists Have Developed an Engineered Protein That Improves Memory

Posted by in categories: biotech/medical, genetics, life extension, neuroscience

Researchers from the Faculty of Medicine and Surgery at the Catholic University, Rome and the Fondazione Policlinico Universitario A. Gemelli IRCCS have developed an engineered protein that boosts memory.

Neuroscientists at the Faculty of Medicine and Surgery of the Catholic University, Rome, and the Fondazione Policlinico Universitario Agostino Gemelli IRCCS have genetically modified a molecule, the protein LIMK1, which is normally active in the brain, with a key role in memory.

They added a “molecular switch” that is activated by administering a drug, rapamycin, known for its several anti-aging effects on the brain.

Nov 17, 2023

‘Lab on a Chip’ Genetic Test device can Identify Viruses within Three Minutes with Top-Level Accuracy

Posted by in categories: biotech/medical, genetics

Compact genetic testing device created for Covid-19 could be used to detect a range of pathogens, or conditions including cancer.

A virus diagnosis device that gives lab-quality results within just three minutes has been invented by engineers at the University of Bath, who describe it as the ‘world’s fastest Covid test’

The prototype LoCKAmp device uses innovative ‘lab on a chip’ technology and has been proven to provide rapid and low-cost detection of Covid-19 from nasal swabs. The research team, based at the University of Bath, say the technology could easily be adapted to detect other pathogens such as bacteria — or even conditions like cancer.

Nov 16, 2023

Crispr Surges After Winning The First CRISPR Gene-Editing Approval

Posted by in categories: biotech/medical, genetics

In a world first, regulators in the U.K. approved Crispr’s gene-editing treatment for two blood diseases on Thursday, and CRSP stock surged.

Nov 16, 2023

AI Model Weighs Epigenetic Factors to Predict Cancer Outcomes

Posted by in categories: biotech/medical, genetics, robotics/AI

Findings lay the groundwork for developing targeted therapies aimed at regulating epigenetic factors in cancer therapy.

Nov 16, 2023

U.K. Greenlights World’s First Crispr Gene Editing Therapy

Posted by in categories: bioengineering, biotech/medical, genetics

The one-time treatment helped relieve symptoms of disease and could free patients from the need for bone marrow transplants or regular blood transfusions, Beach said, adding that the drug hopefully offers a permanent fix for the condition.

The MHRA said it identified no significant safety concerns during the trials and will continue to closely monitor Casgevy’s safety after approval.

Vertex CEO and President Reshma Kewalramanit celebrated Casgevy’s approval as “a historic day in science and medicine” and Samarth Kulkarni, CEO and Chairman of Crispr Therapeutics, said it will hopefully mark “the first of many applications of this Nobel Prize winning technology to benefit eligible patients with serious diseases.” The two companies are hoping for similarly positive decisions from the MHRA’s counterparts in the Europe Union and the U.S., which are in the process of evaluating Casgevy, also known as exa-cel. The Food and Drug Administration is expected to make a decision in early December and has a deadline of December 8. The agency appears poised to follow the MHRA and approve the treatment, with its advisors confident of the drug’s efficacy and benefit but wary of theoretical unintended consequences of genetic modifications.

Nov 15, 2023

Drug-Activated Protein Boosts Memory

Posted by in categories: bioengineering, biotech/medical, chemistry, genetics, life extension, neuroscience

Summary: Researchers made a breakthrough in memory research by genetically modifying the LIMK1 protein, crucial for memory, to be controlled by the drug rapamycin.

This study demonstrates the ability to enhance memory functions by manipulating synaptic plasticity in the brain.

The engineered protein showed significant memory improvement in animal models with age-related cognitive decline, offering potential for innovative treatments for neuropsychiatric diseases like dementia. This ‘chemogenetic’ approach, blending genetics and chemistry, opens new avenues in neurological research and therapy.

Nov 15, 2023

Slow Wave Sleep % Loss Is Associated With An Increased Dementia Risk

Posted by in categories: biotech/medical, genetics, life extension, neuroscience

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Nov 15, 2023

New study identifies 4,749 key gene clusters that influence progression of 32 cancer types

Posted by in categories: biotech/medical, genetics

Researchers at the Mount Sinai Center for Transformative Disease Modeling have released a groundbreaking study identifying 4,749 key gene clusters, termed “prognostic modules,” that significantly influence the progression of 32 different types of cancer. The study, published in Genome Research, serves as a comprehensive resource and lays the foundation for the development of next-generation cancer treatments and diagnostic markers.

Despite significant progress in cancer research, understanding the disease’s genetic intricacies remains challenging. Previous research often focused on isolated gene functions in specific cancer types.

We aimed to fill this knowledge gap by providing a comprehensive analysis of gene-gene interactions across various forms of cancer.

Nov 15, 2023

Scientists debunk notions of optogenetics controlling the human brain

Posted by in categories: biotech/medical, genetics, robotics/AI

In an exclusive interview, Peter Hegemann said AI is more dangerous than optogenetics.


Contrary to popular belief, there is very little chance that optogenetics will be used in the future to control the human brain, says Peter Hegemann, a biochemist and biophysicist, in a conversation with Interesting Engineering (IE) at the Hong Kong Laureate Forum 2023.

Optogenetics is a scientific technique that uses light to control and manipulate cells within living tissues, particularly in the brain. It allows researchers to control the activity of specific neurons with high precision, both in terms of location and timing.

Continue reading “Scientists debunk notions of optogenetics controlling the human brain” »

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