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Category: genetics – Page 63

Medically, AI is helping us with everything from identifying abnormal heart rhythms before they happen to spotting skin cancer. But do we really need it to get involved with our genome? Protein-design company Profluent believes we do.

Founded in 2022 in Berkeley, California, Profluent has been exploring ways to use AI to study and generate new proteins that aren’t found in nature. This week, the team trumpeted a major success with the release of an AI-derived protein termed OpenCRISPR-1.

The protein is meant to work in the CRISPR gene-editing system, a process in which a protein cuts open a piece of DNA and repairs or replaces a gene. CRISPR has been actively in use for about 15 years, with its creators bagging the Nobel prize in chemistry in 2020. It has shown promise as a biomedical tool that can do everything from restoring vision to combating rare diseases; as an agricultural tool that can improve the vitamin D content of tomatoes, and slash the flowering time of trees from decades to months; and much more.

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In order to terraform new planets, we will need to be able transport entire ecologies & ecosystems through interstellar space in the future. Today we will examine how we could build and maintain such environments inside vast arks, generations ships able to colonize our galaxy, and the challenges these starships will face maintaining not just stores of DNA and genetic material but living organisms which depend heavily on other members of their species and other species to survive and thrive, not least of which is human ourselves. Visit our sponsor, Brilliant: https://brilliant.org/IsaacArthur/ Join this channel to get access to perks: / @isaacarthursfia Visit our Website: http://www.isaacarthur.net Join Nebula: https://go.nebula.tv/isaacarthur Support us on Patreon: / isaacarthur Support us on Subscribestar: https://www.subscribestar.com/isaac-a… Group: / 1,583,992,725,237,264 Reddit: / isaacarthur Twitter: / isaac_a_arthur on Twitter and RT our future content. SFIA Discord Server: / discord Listen or Download the audio of this episode from Soundcloud: Episode’s Audio-only version: / exporting-earth Episode’s Narration-only version: / exporting-earth-ships-narration-only Credits: Exporting Earth Episode 150, Season 4 E36 Writers: Isaac Arthur Editors: Darius Said Gregory Leal https://www.gregschool.org/ Jerry Guern Konstantin Sokerin Laura Graham Mark Warburton Matthew Acker Sigmund Kopperud Stuart Graham https://beyondnerva.wordpress.com Producer: Isaac Arthur Cover Artist: Jakub Grygier https://www.artstation.com/jakub_grygier Graphics Team: Darth Biomech https://www.artstation.com/darth_biomech Fishy Tree https://www.deviantart.com/fishytree/ Jarred Eagley Jeremy Jozwik https://www.artstation.com/zeuxis_of_… Katie Byrne Ken York / ydvisual Krisitijan Tavcar https://www.miragedereve.com LegionTech Studios Sam McNamara Sergio Boterio https://www.artstation.com/sboterod?f… Narrator: Isaac Arthur Music Manager: Luca DeRosa — [email protected] Music: Dracovallis, “Golden Meadows” https://dracovallis.bandcamp.com/ NJ Mandaville, “Intrumental Background 1” / nj-mandaville Kevin Macleod, “Infinite Wonder” / @incompetech_kmac Chris Zabriskie, “Candlepower” http://chriszabriskie.com Kai Engel, “Endless Story About Sun and Moon” https://www.kai-engel.com/ Lombus, “Amino” https://lombus.bandcamp.com Aerium, “Windmill Forests” / @officialaerium Epic Mountain, “Rising Sky” / epicmountain.

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Every cuckoo is an adopted child—raised by foster parents, into whose nest the cuckoo mother smuggled her egg. The cuckoo mother is aided in this subterfuge by her resemblance to a bird of prey. There are two variants of female cuckoos: a gray morph that looks like a sparrowhawk, and a rufous morph. Male cuckoos are always gray.

“With this mimicry, the bird imitates dangerous predators of the birds, so that they keep their distance instead of attacking,” says Professor Jochen Wolf from LMU Munich.

Together with researchers at CIBIO (Centro de Investigação em Biodiversidade e Recursos Genéticos, Portugal), the evolutionary biologist has investigated the genetic foundations of the variant coloring, which is limited to females and emerged over the long evolutionary arms race between host and . The research is published in the journal Science Advances.

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Using DNA and proteins, scientists have created new synthetic cells that act like living cells. Blurring the line between artificial and living materials, these cells can be reprogrammed to perform multiple functions, opening the door to new synthetic biology tech that goes beyond nature’s abilities.

Cells get their structure and stability from their cytoskeleton, a crosslinked framework of proteins that encases and protects other components. Depending on the type of cell, this cytoskeleton can be flexible to different degrees and respond in different ways to their environment, giving cells their specialized abilities.

For the new study, scientists from the University of North Carolina at Chapel Hill developed synthetic, self-assembling cytoskeletons, built out of DNA, peptides and other genetic material.

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Scientists champion global genomic surveillance using the latest technologies and a ‘One Health’ approach to protect against novel pathogens like avian influenza and antimicrobial resistance, catching epidemics before they start.

The COVID-19 pandemic turned the world upside down. In fighting it, one of our most important weapons was genomic surveillance, based on whole genome sequencing, which collects all the genetic data of a given microorganism. This powerful technology tracked the spread and evolution of the virus, helping to guide public health responses and the development of vaccines and treatments.

But genomic surveillance could do much more to reduce the toll of disease and death worldwide than just protect us from COVID-19. Writing in the journal Frontiers in Science, an international collective of clinical and public health microbiologists from the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) calls for investment in technology, capacity, expertise, and collaboration to put genomic surveillance of pathogens at the forefront of future pandemic preparedness.

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Cognitive decline and dementia already affect more than 55 million people worldwide. This number is projected to skyrocket over the next few decades as the global population ages.

There are certain risk factors of cognitive decline and dementia that we cannot change – such as having a genetic predisposition to these conditions. But other risk factors we may have more power over – with research showing certain modifiable lifestyle habits, such as smoking, obesity and lack of exercise, are all linked to higher risk of dementia.

What role nutrition plays in preventing cognitive decline and dementia has also been the focus of scientific research for quite some time.

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Thsi is a year old. But at 27 minutes David gets asked a couple fo “when” questions.

Dr. David Sinclair presents the progress of epigenetic reprogramming and rejuvenation in this video. He’s also answering questions on when he thinks the rejuvenation therapy be available in the Q\&A session at the end of the presentation.

00:54 Presentation.

Continue reading “Will Rejuvenation Therapy Be Available In Our LIFETIME? Gene Therapy VS Small Molecules” | >

The International Space Station has long been known as a unique — and uniquely gross — environment. But according to a new NASA study, it has stuff growing on it that is straight-up alien, too.

In a press release, NASA said that when scientists from the Jet Propulsion Lab looked at samples of the drug-resistant Enterobacter bugandensis bacteria found on the orbital outpost, they found that the strains had mutated into something that literally doesn’t exist on Earth.

“Study findings indicate that under stress, the ISS isolated strains were mutated and became genetically and functionally distinct compared to their Earth counterparts,” the press release reads. “The strains were able to viably persist in the ISS over time in significant abundances.”

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