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Genetically engineered T cells could lead to therapies for autoimmune diseases

A new study has found that a novel T cell genetically engineered by University of Arizona Health Sciences researchers is able to target and attack pathogenic T cells that cause Type 1 diabetes, which could lead to new immunotherapy treatments.

The immune system fights bacteria, viruses and other pathogens by utilizing several types of T , all of which have receptors that are specific to particular antigens. On killer T cells, the receptor works in concert with three signaling modules and a coreceptor to destroy the . Michael Kuhns, Ph.D., an associate professor in the UArizona College of Medicine—Tucson Department of Immunobiology, copied the evolutionary design to engineer a five-module , or 5MCAR, T cell.

“The 5MCAR was an attempt to figure out if we could build something by biomimicry, using some of evolution’s natural pieces, and redirect T cells to do what we want them to do. We engineered a 5MCAR that would direct killer T cells to target autoimmune T cells that mediate Type 1 diabetes,” said Dr. Kuhns, who is member of the UArizona Cancer Center, BIO5 Institute and Arizona Center on Aging. “So now, a killer T cell will actually recognize another T cell. We flipped T cell-mediated immunity on its head.”

COVID vaccine made from GMO tobacco? It’s now in human trials

“BAT said KBP had cloned a portion of the genetic sequence of coronavirus and developed a potential antigen, which is then inserted into tobacco plants for reproduction.”

😲😲😲


While large pharmaceutical companies are already producing vaccines, [the company British American Tobacco] believes its own can be produced in six weeks, compared with the several months it takes using conventional methods.

This, the company claims, is because of proprietary technology that allows elements of the vaccine to gather quickly on tobacco plants.

BAT also says its vaccine is stable at room temperature, unlike the Pfizer/BioNTech jab being administered in the UK, which must be stored and transported at about-70C.

Tweaking two genes in cotton doubles crop yields—and may do the same in wheat, rice and corn

“The research was conducted by overexpressing two different genes, the AVP1 and OsSIZ1.”

😯😯😯


One group of Texas Tech University researchers has found a way to double fiber yield for cotton in semi-arid areas like that of West Texas, where drought, heat and salinity are working against farmers.

Hong Zhang is a professor of Plant Molecular Biology and Plant Biotechnology at Texas Tech. A few years ago, his group published a paper showing that he could increase cotton yield by 35%-40% in dryland conditions.

But he has continued to work on different genetic changes to cotton that could lead to even better results, and a new paper published in “Plant Biotechnology Journal” in September details those results. During Zhang’s first year of experimenting with a new set of genetic modifications, the fiber yield from cotton crops was up 133%.

Jawless lamprey takes a bite out of cancer gene evolution

Mice, fruit flies and dogs are common creatures of laboratories across the country, valuable to researchers for their genetic proximity to humans. But what about lampreys?

A new Yale School of Public Health study has enlisted this unlikely and slimy ally in the fight against .

By carefully tracing the evolution of a select number of cancer-causing genes in a variety of species, the researchers evaluated which animals are—and are not—effective in gauging how an analog of those genes in humans can lead to cancer. What they found is surprising: such as lampreys share significant similarities in these certain genes compared to humans, while do not. Their findings, published in the journal Genome Biology and Evolution, will help molecular biologists and other scientists as they work to find potential cures to certain cancers, such as lymphoma.

Raccoon intelligence at the borderlands of science

All hail the powerful One climbed my wood structure that went straight up then went to the roof o.o. Also their hands make them like chimps.


How does intelligence ofs compare with other species? That was a topic of heated debate between 1905 and 1915 within the then-nascent field of comparative psychology.

In 1907, psychologist Lawrence W. Cole, who had established a colony ofs at the University of Oklahoma, and Herbert Burnham Davis, a doctoral student at Clark University, each published the results of nearly identical experiments on the processes of learning, association and memory ins. They relied on E.L. Thorndike’s puzzle-box methodology, which involved placing animals in wooden crates from which the animal had to escape by opening the latch or sequence of latches. They observed the number of trials required for successful completion and the extent to which the animal retained the ability to solve the same problem more quickly when confronted again with it. Using this method, they sought what Davis called “a tolerable basis” for ranking the intelligence ofs on the phylogenetic scale of evolutionary development. They independently concluded thats bested the abilities of cats and dogs, most closely approximating the mental attributes of monkeys.

Raccoons had attracted interest because they flourished, rather than receded, in the face of human expansion. Over the centuries, people had hunteds for food and fur, decried them as agricultural pests and urban bandits, and kept them as household pets. This latter role brought the species to psychologists’ attention. Cole reported that he got the idea to work withs from observing the behavior of a pet kept at a local market. At the time, most animal experiments being conducted occurred on the borderlands of academic research, nature study and domestic life. Scientists such as Charles Darwin, William James and James Mark Baldwin all developed psychological theories based upon observations of their own children and pets. Cole’ss, for example, lived simultaneously as research objects and amusing pets, a relationship that shaped how these experiments were presented to and perceived by the public. Despite Davis’s protests, a widely printed newspaper story depicted his puzzle-box experiments as an example of teaching “tricks” to one’s pets.

FDA Approves Gene-Hacked Pigs for Human Consumption

I think I want non-gene hacked pigs for my supper. 😃


For the second time ever, the U.S. Food and Drug Administration (FDA) approved a gene-hacked animal for human consumption.

In this case, it’s the GalSafe pig, CNN reports, a genetically modified swine that’s safe even for people with allergies to eat. All in all, it’s a fresh sign that genetically-altered animals and sophisticated gene-hacking technology are now becoming commercially viable and entering the mainstream.

“Today’s first ever approval of an animal biotechnology product for both food and as a potential source for biomedical use represents a tremendous milestone for scientific innovation,” FDA Commissioner Stephen Hahn said in a press release.

Kris Verburgh | How to Live Longer? High-Tech and Low-Tech Approaches

A bit of everything here from hallmarks of aging to epigenetic reprogramming(which effects telomeres, gene expression, etc) and even diet.


In this talk given at Ending Age-Related Diseases 2020, Dr. Kris Verburgh of the Free University of Brussels discusses the methods by which people might lead longer, healthier lives. While some of these methods involve the use of advanced rejuvenation biotechnology techniques, others are simpler to implement and require a minimum amount of technology, such as nutrition and exercise, along with health-monitoring technology that already exists in the public space.

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Giving Blind Runners Independence With AI

Being able to see, move, and exercise independently is something most of us take for granted. [Thomas Panek] was an avid runner before losing his sight due to a genetic condition, and had to rely on other humans and guide dogs to run again. After challenging attendants at a Google hackathon, Project Guideline was established to give blind runners (or walkers) independence from a cane, dog or another human, while exercising outdoors. Using a smartphone with line following AI software, and bone conduction headphones, users can be guided along a path with a line painted on it. You need to watch the video below to get a taste of just how incredible it is for the users.

Getting a wheeled robot to follow a line is relatively simple, but a running human is by no means a stable sensor platform. At the previously mentioned hackathon, developers put together a rough proof of concept with a smartphone, using its camera to recognize a painted line on the ground and provide left/right audio cues. As the project developed, the smartphone was attached to a waist belt and bone conduction headphones were used, which don’t affect audio situational awareness as much as normal headphones.

The shaking and side to side movement of running, and varying light conditions and visual obstructions in the outdoors made the problem more difficult to solve, but within a year the developers had completed successful running tests with [Thomas] on a well-lit indoor track and an outdoor pedestrian path with a temporary line. For the first time in 25 years, [Thomas] was able to run independently.

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