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Category: genetics – Page 377

From DNA to protein — 3D

We can reprogram our DNA. The nucleus of a cell is not read only. It is actually read and write. Basically, the cell is a programmable device, in response to environmental information.

The templates for protein synthesis are RNA (ribonucleic acid) molecules. In particular, a class of RNA molecules called messenger RNA (mRNA) are the information-carrying intermediates in protein synthesis. Other RNA molecules, such as transfer RNA (tRNA) and ribosomal RNA (rRNA), are part of the protein-synthesizing machinery. All forms of cellular RNA are synthesized by RNA polymerases that take instructions from DNA templates. This process of transcription is followed by translation, the synthesis of proteins according to instructions given by mRNA templates.

The flow of information is dependent on the genetic code, which defines the relation between the sequence of bases in DNA (or its mRNA transcript) and the sequence of amino acids in a protein.

We can send therapeutic messages to the DNA inside the stem cells’ nucleus. DNA sends the information (in the form of nerve impulses) to the RNA molecules called messenger RNA. The transfer RNA synthesizes proteins to carry out the instructions given by messenger RNA templates for the stem cells to become new neurons and cells to replace the neurons and cells that were damaged or destroyed.

This 3D animation shows how proteins are made in the cell from the information in the DNA code.

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Transhumanism 2.0 (Full Documentary)

TABLE OF CONTENTS —————
:00–15:11 : Introduction
:11–36:12 CHAPTER 1: POSTHUMANISM
a. Neurotechnology b. Neurophilosophy c. Teilhard de Chardin and the Noosphere.

—————————————————————————————–
POSTHUMAN TECHNOLOGY
—————————————————————————————–

:12–54:39 CHAPTER 2 : TELEPATHY/ MIND-READING
a. MRI
b. fMRI
c. EEG
d. Cognitive Liberty e. Dream-recording, Dream-economies f. Social Credit Systems g. Libertism VS Determinism.

:02:07–1:25:48 : CHAPTER 3 : MEMORY/ MIND-AUGMENTING
a. Memory Erasure and Neuroplasticity b. Longterm Potentiation (LTP/LTD)
c. Propanolol d. Optogenetics e. Neuromodulation f. Memory-hacking g. Postmodern Dystopias h. Total Recall, the Matrix, and Eternal Sunshine of the Spotless Mind i. Custom reality and identity.

:25:48–1:45:14 CHAPTER 4 : BCI/ MIND-UPGRADING
a. Bryan Johnson and Kernel b. Mark Zuckerberg and Neuroprosthetics c. Elon Musk, Neural Lace, and Neuralink d. Neurohacking, Neuroadvertizing, Neurodialectics e. Cyborgs, Surrogates, and Telerobotics f. Terminator, Superintelligence, and Merging with AI
g. Digital Analogs, Suffering, and Virtual Drugs h. Neurogaming and “Nervana” (technological-enlightenment)

:45:14 −2:02:57 CHAPTER 5 : CONNECTOME/ MIND-MAPPING

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New molecular insights into how gut bacteria influences memory

New research from an international team of scientists has tracked a compelling series of connections between the gut microbiome and memory. Using a novel mouse model engineered to simulate the genetic diversity of a human population, the study illustrates how genetics can influence memory via bacterial metabolites produced in the gut.

Over the past few years there has been significant research interest in the relationship between memory, cognition and the gut microbiome. While certain families of bacteria that live in our gut have been implicated in memory function, this new study set out to investigate the connection from a different angle, starting with the role genetics play in this relationship.

“To know if a microbial molecule influenced memory, we needed to understand the interaction between genetics and the microbiome,” explains co-corresponding author on the study, Antoine Snijders.

Hidden symmetry found in chemical kinetic equations

Rice University researchers have discovered a hidden symmetry in the chemical kinetic equations scientists have long used to model and study many of the chemical processes essential for life.

The find has implications for drug design, genetics and biomedical research and is described in a study published this month in the Proceedings of the National Academy of Sciences. To illustrate the biological ramifications, study co-authors Oleg Igoshin, Anatoly Kolomeisky and Joel Mallory of Rice’s Center for Theoretical Biological Physics (CTBP) used three wide-ranging examples: protein folding, enzyme catalysis and motor protein efficiency.

In each case, the researchers demonstrated that a simple mathematical ratio shows that the likelihood of errors is controlled by kinetics rather than thermodynamics.

Deep-space travel, colonization may rely on genetically engineered life forms

On Earth, there are organisms that resist radiation, heat, cold, and drying, even to the point of being able to live in the space vacuum.

Genetic biotechnology is usually discussed in the context of current and emerging applications here on Earth, and rightly so, since we still live exclusively in our planetary cradle. But as humanity looks outward, we ponder what kind of life we ought to take with us to support outposts and eventually colonies off the Earth.

While the International Space Station (ISS) and the various spacecraft that ferry astronauts on short bouts through space depend on consumables brought up from Earth to maintain life support, this approach will not be practical for extensive lunar missions, much less long term occupation of more distant sites. If we’re to build permanent bases, and eventually colonies, on the Moon, Mars, asteroids, moons of outer planets or in free space, we’ll need recycling life support systems. This means air, water, and food replenished through microorganisms and plants, and it’s not a new idea.

Space exploration enthusiasts have been talking about it for decades, and it’s the most obvious application of microorganisms and plants transplanted from Earth. What is new, however, is the prospect of a comprehensive use of synthetic biology for a wide range of off-Earth outpost and colonization applications.

Molecules identified that reverse cellular aging process

Central to a lot of scientific research into aging are tiny caps on the ends of our chromosomes called telomeres. These protective sequences of DNA grow a little shorter each time a cell divides, but by intervening in this process, researchers hope to one day regulate the process of aging and the ill health effects it can bring. A Harvard team is now offering an exciting pathway forward, discovering a set of small molecules capable of restoring telomere length in mice.

Telomeres can be thought of like the plastic tips on the end of our shoelaces, preventing the fraying of the DNA code of the genome and playing an important part in a healthy aging process. But each time a cell divides, they grow a little shorter. This sequence repeats over and over until the cell can no longer divide and dies.

This process is linked to aging and disease, including a rare genetic disease called dyskeratosis congenita (DC). This is caused by the premature aging of cells and is where the team focused its attention, hoping to offer alternatives to the current treatment that involves high-risk bone marrow transplants and which offers limited benefits.

Sustainable light achieved in living plants

The movie Avatar evoked an imaginary world of lush bioluminescent jungles. Now the popular fascination for sustainably glowing foliage is being realized through advances in designer genetics. This week in Nature Biotechnology, scientists have announced the feasibility of creating plants that produce their own visible luminescence.

The scientists revealed that bioluminescence found in some mushrooms is metabolically similar to the natural processes common among plants. By inserting DNA obtained from the mushroom, the scientists were able to create plants that glow much brighter than previously possible.

This biological can be used by scientists for observing the inner workings of plants. In contrast to other commonly used forms of bioluminescence, such as from fireflies, unique chemical reagents are not necessary for sustaining mushroom bioluminescence. Plants containing the mushroom DNA glow continuously throughout their lifecycle, from seedling to maturity.