Lifeboat Foundation

A chance finding ten years ago led to the creation by researchers of the Spanish National Cancer Research Centre (CNIO) of the first mice born with much longer telomeres than normal in their species. Given the relationship between telomeres and ageing – telomeres shorten throughout life, so older organisms have shorter telomeres -, scientists launched a study generating mice in which 100% of their cells had hyper-long telomeres. The findings are published in Nature Communications and show only positive consequences: the animals with hyper-long live longer in better health, free from cancer and obesity. The most relevant thing for the authors is the fact that longevity has been significantly increased for the first time ever without any genetic modification.

“This finding supports the idea that, when it comes to determining longevity, genes are not the only thing to consider”, indicates Maria Blasco, Head of the CNIO Telomeres and Telomerase Group and intellectual author of the paper. “There is margin for extending life without altering the genes”.

Telomeres form the end of chromosomes, in the nucleus of each cell in the body. Their function is to protect the integrity of the genetic information in DNA. Whenever the cells divide the telomeres, they are shortened a little, so one of the main characteristics of ageing is the accumulation of short telomeres in cells. “Telomere shortening is considered to be one of the primary causes of ageing, given that short telomeres cause ageing of the organism and reduce longevity”, as the paper published in Nature Communications explains.

Dr. Nick interviews Liz Parrish, the Founder, and CEO of BioViva Sciences USA Inc at RaadFest in Las Vegas. Nick Delgado, ABAAHP is one of the leading experts in the field of bio-identical hormones, herbs, nutrition, exercise, partner intimacy, mindful self-motivation. Our goal is to help you restore your cellular health to radically improve the quality of life and world health.
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Liz Parrish is the Founder and CEO of BioViva Sciences USA Inc. BioViva is committed to extending healthy lifespans using gene therapy. Liz is known as “the woman who wants to genetically engineer you,” she is a humanitarian, entrepreneur and innovator and a leading voice for genetic cures.
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Correlations between pain phenotypes and psychiatric traits such as depression and the personality trait of neuroticism are not fully understood. In this study, we estimated the genetic correlations of eight pain phenotypes (defined by the UK Biobank, n = 151,922–226,683) with depressive symptoms, major depressive disorders and neuroticism using the cross-trait linkage disequilibrium score regression (LDSC) method integrated in the LD Hub. We also used the LDSC software to calculate the genetic correlations among pain phenotypes. All pain phenotypes, except hip pain and knee pain, had significant and positive genetic correlations with depressive symptoms, major depressive disorders and neuroticism. All pain phenotypes were heritable, with pain all over the body showing the highest heritability (h² = 0.31, standard error = 0.072). Many pain phenotypes had positive and significant genetic correlations with each other indicating shared genetic mechanisms. Our results suggest that pain, neuroticism and depression share partially overlapping genetic risk factors.

New research from a team of Canadian scientists has for the first time demonstrated how exposure to Narrow Band Ultraviolet B light (UVB) can directly influence gut microbiome diversity in humans. The research hypothesizes that this result is modulated by vitamin D and presents evidence of a novel skin-gut communication pathway.

Autoimmune diseases such as inflammatory bowel disease (IBD) and multiple sclerosis are thought to be caused by a number of environmental and genetic factors. Gut bacterial diversity, exposure to sunlight and vitamin D levels, have all been observed as influential factors for inflammatory disease, however a new study is asserting a causal chain may link all three of these elements.

The new research examined 21 female subjects who were all administered three 60-second full-body UVB exposure sessions across one week. Blood and fecal samples were taken from all subjects at the beginning and end of the study to track changes to vitamin D levels and gut bacterial diversity. Half of the subjects were noted as having taken vitamin D supplements across the prior three winter months.

The low cost of genetic testing has prompted a slew of Chinese companies, including 23Mofang and Shenzhen-based WeGene, to enter the market and tap growing demand in the world’s second largest economy, which is expected to reach US$4.3 billion by 2023. Compared to the US, China remains a fairly nascent market for direct-to-consumer genetic testing.

The low cost of direct-to-consumer genetic testing has prompted a slew of Chinese companies to enter the domestic market, which is expected to reach US$4.3 billion by 2023.

Researchers in epigenetics are learning how to slow down—and even turn back—the clock that governs aging in our cells.

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Rare genetic variants could point to new treatments for severe psychiatric disorder.

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