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Category: genetics – Page 237

Jamie Metzl is an author specializing in topics of genetic engineering, biotechnology, and geopolitics. Please support this podcast by checking out our sponsors:
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Continue reading “Jamie Metzl: Lab Leak Theory | Lex Fridman Podcast #247” | >

Roche and its Genentech subsidiary have committed up to $12 billion to Recursion in return for using its Recursion Operating System (OS) to advance therapies in 40 programs that include “key areas” of neuroscience and an undisclosed oncology indication.

Recursion OS applies machine learning and high-content screening methods in what the companies said would be a “transformational” model for tech-enabled target and drug discovery.

The integrated, multi-faceted OS is designed to generate, analyze and glean insights from large-scale proprietary biological and chemical datasets—in this case, extensive single-cell perturbation screening data from Roche and Genentech—by integrating wet-lab and dry-lab biology at scale to phenomically capture chemical and genetic alterations in neuroscience-related cell types and select cancer cell lines.

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Lex Fridman Podcast full episode: https://www.youtube.com/watch?v=K78jqx9fx2I
Please support this podcast by checking out our sponsors:
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GUEST BIO:
Jamie Metzl is an author specializing in topics of genetic engineering, biotechnology, and geopolitics.

PODCAST INFO:
Podcast website: https://lexfridman.com/podcast.
Apple Podcasts: https://apple.co/2lwqZIr.
Spotify: https://spoti.fi/2nEwCF8
RSS: https://lexfridman.com/feed/podcast/
Full episodes playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOdP_8GztsuKi9nrraNbKKp4
Clips playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOeciFP3CBCIEElOJeitOr41

SOCIAL:

Continue reading “Sam Harris and Brett Weinstein Twitter feud | Jamie Metzl and Lex Fridman” | >

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Genetic Engineering and DNA alteration is an emerging technology with huge ramifications in the future, including potentially altering the DNA of adult humans, not just embryos or plants & animals.

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Credits:

Continue reading “DNA Manipulation in Living Subjects” | >

The earliest genetic traces of Native American ancestry among Polynesians.

The peopling of Polynesia was a stunning achievement: Beginning around 800 C.E., audacious Polynesian navigators in double-hulled sailing canoes used the stars and their knowledge of the waves to discover specks of land separated by thousands of kilometers of open ocean. Within just a few centuries, they had populated most of the Pacific Ocean’s far-flung islands. Now, researchers have used modern DNA samples to trace the exploration in detail, working out what order the islands were settled in and dating each new landfall to within a few decades.

“The whole question of the settlement of Polynesia has been going on for 200 years,” says University of Hawaii, Manoa, archaeologist Patrick Kirch, who was not involved in the research. “This is a really great paper, and I’m happy to see it.”

Archaeologists already had hints of how this great exploration took place. Studying the styles of stone tools and carvings, as well as languages, of the people on the various islands had suggested the original ancestors traced back to Samoa and that the expansion ended halfway across the ocean in Rapa Nui, or Easter Island. But they disagreed on whether it happened in a few centuries, beginning around 900 C.E., or started much earlier and lasted 1 millennium or more.

Continue reading “‘No one could have predicted.’ DNA offers surprises on how Polynesia was settled” | >

Chinese scientists developed a targeted delivery system that can conduct precise gene-editing for inflammatory bowel disease. /CFP

Chinese scientists have developed a targeted delivery system that can bring gene-editing tools to colon cells, offering a precise cure for inflammatory bowel disease.

The study, published on Thursday in the journal Science Advances, reported a CRISPR-Cas9 prodrug nanosystem that can transport a gene-editing protein exclusively to inflammatory lesions in mice colons and then “switch on” the protein.

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Many intractable diseases are the result of a genetic mutation. Genome editing technology promises to correct the mutation and thus new treatments for patients. However, getting the technology to the cells that need the correction remains a major challenge. A new study led by CiRA Junior Associate Professor Akitsu Hotta and in collaboration with Takeda Pharmaceutical Company Limited as part of the T-CiRA Joint Research Program reports how lipid nanoparticles provide an effective means for the delivery to treat Duchenne muscular dystrophy (DMD) in mice.

Last year’s Nobel Prize for Chemistry to the discoverers of CRISPR-Cas9 cemented the impact of genome editing technology. While CRISPR-Cas9 can be applied to agriculture and livestock for more nutritious food and robust crops, most media attention is on its medical potential. DMD is just one of the many diseases that researchers foresee a treatment using CRISPR-Cas9.

“Oligonucleotide drugs are now available for DMD, but their effects are transient, so the patient has to undergo weekly treatments. On the other hand, CRISPR-Cas9 effects are long lasting,” said Hotta.

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Gene therapy is a powerful developing technology that has the potential to address myriad diseases. For example, Huntington’s disease, a neurodegenerative disorder, is caused by a mutation in a single gene, and if researchers could go into specific cells and correct that defect, theoretically those cells could regain normal function.

A major challenge, however, has been creating the right “delivery vehicles” that can carry genes and molecules into the that need treatment, while avoiding the cells that do not.

Now, a team led by Caltech researchers has developed a gene-delivery system that can specifically target cells while avoiding the . This is important because a gene therapy intended to treat a disorder in the brain, for example, could also have the side effect of creating a toxic immune response in the liver, hence the desire to find delivery vehicles that only go to their intended target. The findings were shown in both mouse and marmoset models, an important step towards translating the technology into humans.

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