https://gotopnews.com/post/1979903
Scientists created mice with two biological dads by producing eggs from male cells, which is a development that opens radical new possibilities for reproduction. Progress can ultimately pave way for treatments for severe infertility forms and increase possibility of attracting couples of same gender to have a biological child in future. Hayashi, who presented development at the third International Human Genome Regulation Summit at Francis Crick Institute in London on Wednesday, predicts it would be technically possible to create a human egg from a male skin cell in ten years. Considering that human eggs did not create eggs, he argued this timeline was optimistic. Previously, scientists have created mice technically with a detailed step chain, including genetic engineering. This is first time that can be applied first time, eggs were raised from male cells and pointing to an important progress. He was trying to reproduce with human cells, but there would be important obstacles for use of eggs grown in laboratory clinical purposes, including creating safety. “In terms of technology, it will be possible even in 10 years in 10 years, ve he personally added that the technology used clinically to allow two men to have a baby. Orum I don’t know if they are ready reproduction,” he said.“This is a question not only for the scientific program, but also[society].” Technique, X chromosome is missing or partially missing a copy of the turner syndrome, including women with severe infertility forms can be applied to treat and Hayashi, this application is the primary motivation for research, he said. Others argued that translating technique into human cells may be challenging. Human cells need much longer agricultural periods to produce a mature egg, which can increase the risk of undesirable genetic changes. Profess George Daley, the Dean of Harvard Medical Faculty, described the study as “fascinating„ but other researches also showed that creating gamet creating from human cells in laboratory is more difficult than mouse cells.said. The study, which was sent to be leading magazine, was based on a number of complex steps to transform skin cell that carries the combination of male XY chromosomes into an egg. Men’s skin cells were re-programmed into a stem cell-like condition to form the induced pluripotent root cells. Then the Y chromosome of these cells was deleted and changed and ” borrowed from another cell to produce IPS cells with two identical X chromosome. Hayashi said, ” The trick, greatest trick, the reproduction of X chromosome,” he said. ” We really tried to establish a system to replicate the X chromosome.” Finally, cells were grown in an ovary organoid with a cultural system designed to replicate the conditions within ovary. When Yumurtas were fertilized with normal sperm, scientists obtained approximately 600 embryos implanted in the mice, which resulted in birth of seven mouse offspring. ‘Efficiency was lower than the efficiency obtained by normal female-derived eggs, where approximately 5% of the embryos continued to produce a lively birth. Baby mice looked healthy, had a normal life, and as an adult continued to the offspring. ” They look good, they grow normal, they become a father, Hay Hayashi said. He and his colleagues are now trying to increase the creation of eggs grown in the laboratory using human cells. Working on Gamets grown in the laboratory at the University of California Los Angeles, Prof Amander Clark said that it would be a ” big jump in, because scientists have not yet created human eggs from women’s cells. Scientists have created the premises of human eggs, but so far, cells, mature eggs and sperm, a critical cell division step, which has stopped development before the point of meiosis. It can be 10 years or 20 years.”
A quick introduction to Yamanaka factors!
The quest for longevity has always been with us. Ever since the ancient kings of old we have been trying everything we can think of in order to stave off death and disease, with most of our efforts unfortunately baring little fruit. However, as it turns out, the power to reverse the aging process has been nestled within us this whole time. Not in the metaphorical sense, but rather in the quite literal sense. For you see, we have been reversing the aging process every single time we have reproduced.
Have you ever wondered how it is that regardless of how old the parents of a child are, the child is never born ‘pre-aged?’. This seems like a ridiculous question, but if the genetic material that came from the parents (especially from the father) has already undergone the aging process, then how is it that ‘genetic aging’ is not passed onto the child? If such a process were to occur, then it would obviously spell doom for our entire species, as we would eventually accumulate age with each subsequent generation and we would very quickly perish. Yet, this obviously does not happen. So the question was asked, why is this?
X-ray diffraction has been used for more than a hundred years to understand the structure of crystals or proteins—for instance, in 1952 the well-known double helix structure of the DNA that carries genetic information was discovered in this way. In this technique, the object under investigation is bombarded with short-wavelength X-ray beams. The diffracted beams then interfere and thus create characteristic diffraction patterns from which one can gain information about the shape of the object.
For several years now it has been possible to study even single nanoparticles in this way, using very short and extremely intense X-ray pulses. However, this typically only yields a two-dimensional image of the particle. A team of researchers led by ETH professor Daniela Rupp, together with colleagues at the universities of Rostock and Freiburg, the TU Berlin and DESY in Hamburg, have now found a way to also calculate the three-dimensional structure from a single diffraction pattern, so that one can “look” at the particle from all directions. In the future it should even be possible to make 3D-movies of the dynamics of nanostructures in this way. The results of this research have recently been published in the scientific journal Science Advances.
Daniela Rupp has been assistant professor at ETH Zurich since 2019, where she leads the research group “Nanostructures and ultra-fast X-ray science.” Together with her team she tries to better understand the interaction between very intense X-ray pulses and matter. As a model system they use nanoparticles, which they also investigate at the Paul Scherrer Institute. “For the future there are great opportunities at the new Maloja instrument, on which we were the first user group to make measurements at the beginning of last year. Right now our team there is activating the attosecond mode, with which we can even observe the dynamics of electrons,” says Rupp.
A method for turning male cells into egg cells in mice could one day be used to help men in a same-sex couple have children who are genetically related to them both.
Reverse the aging process and live decades longer? Transfer your brain onto a database and achieve digital immortality? Humans one day may have such options.
