In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don’t Have To, and the host of the Lifespan Podcast, which launches January 5, 2022. In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. We discuss fasting and supplementation with resveratrol, NAD, metformin, and NMN. We also discuss the use of caffeine, exercise, cold exposure, and why excessive iron load is bad for us. We discuss food choices for offsetting aging and promoting autophagy (clearance of dead cells). And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age. We also discuss the future of longevity research and technology. This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it. #HubermanLab #DavidSinclair #Longevity
Category: genetics – Page 164
The future of heart health: Researchers develop vaccine to lower cholesterol
Nearly two in five U.S. adults have high cholesterol, according to the Centers for Disease Control and Prevention (CDC). Untreated, high cholesterol can lead to heart disease and stroke, which are two of the top causes of death in the U.S. Worldwide; cardiovascular diseases claim nearly 18 million lives every year, according to the World Health Organization.
A new vaccine developed by researchers at The University of New Mexico School of Medicine could be a game-changer, providing an inexpensive method to lower “bad” LDL cholesterol, which creates dangerous plaques that can block blood vessels.
In a recent study published in npj Vaccines, a team led by Bryce Chackerian, Ph.D., Regents’ Professor in the Department of Molecular Genetics & Microbiology, reported the vaccines lowered LDL cholesterol almost as effectively as an expensive class of drugs known as PCSK9 inhibitors.
A CRISPR pioneer looks back as the first gene-editing therapy is approved
In 2007, Luciano Marraffini struck out on what was then a scientifically lonely path: to understand CRISPR, which had been discovered in bacteria only about a decade before.
Seventeen years later, we all know what CRISPR is: a revolution in medicine. A once-in-a-lifetime scientific breakthrough. The most promising tool for gene therapy ever discovered. But back then, “clustered regularly interspaced short palindromic repeats” were merely curious genetic fragments with no known purpose.
“When I started, there was nothing that indicated that it was going to one day help people to cure genetic diseases,” Marraffini recalls.
Unveiling the Dark Genome: LINE-1’s Role in Disease
Summary: A new study illuminated a part of the “dark genome,” specifically focusing on LINE-1, a genetic element linked to various diseases and aging.
Researchers have provided the first high-resolution images and structural details of LINE-1, an “ancient genetic parasite” with about 100 active copies in each person. This research, involving international collaboration, reveals LINE-1’s mechanism of integrating DNA into the human genome and its correlation with diseases like cancer and neurodegeneration.
The study’s findings offer a foundation for potential treatments targeting this retrotransposon.
Avoiding The Age-Related Increase For Blood Pressure
Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhDDiscount Links: Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7x…
Vertex’s First Crispr Gene Editing Therapy Gets EU Backing
Europe’s health regulator followed the US and UK in backing the first gene-editing therapy to use Crispr technology, a Vertex Pharmaceuticals Inc. and Crispr Therapeutics AG treatment for sickle cell disease.
The European Medicines Agency’s expert panel recommended on Friday authorizing the Vertex and Crispr drug, Casgevy, for people with severe sickle cell disease and another serious hereditary blood disorder, beta-thalassemia, which is traditionally treated with repeated transfusions. Vertex said before the ruling that it had yet to establish a European list price for the one-time therapy, which costs $2.2 million in the US.
The treatment makes precisely targeted changes in patients’ DNA, a months-long process that requires removing bone marrow and a stem cell transplant. In Europe, Vertex said its initial focus will be on countries with the highest numbers of patients, including France, Italy, the UK and Germany.
8th FNIP webinar|1st speaker|Dr. G. Perea: Time-Controlling Activation of Astrocyte–Neuron Networks
ABSTRACT: Optogenetics has been widely expanded to enhance or suppress neuronal activity and it has been recently applied to glial cells. Here, we will discuss about a novel approach based on selective expression of melanopsin, a G-protein-coupled photopigment, in astrocytes. We will show the selective expression of melanopsin in astrocytes allows triggering astrocytic Ca2+ signalling, but also studying astrocyte–neuron networks and the behavioral astrocytic contribution.\
Chair and introduction: Dr. Letizia Mariotti (CNR — Institute of Neuroscience)
Aging Rewind: What The Studies Show — Can Young Plasma Turn Back the Epigenetic Clock?
A quickie about E5.
Dr. Steve Horvath shares some studies on evaluating whether young plasma fraction affects the epigenetic clock and lifespan in this short video.\
https://pubmed.ncbi.nlm.nih.gov/37875…\
https://www.ncbi.nlm.nih.gov/pmc/arti…\
https://pubmed.ncbi.nlm.nih.gov/37500…\
https://www.theguardian.com/science/2…\
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DISCLAIMER: The information and opinions expressed in this video are for informational purposes only and are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please consult with your doctor or other qualified health provider before start taking any supplements. \
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Researchers define new class of regulatory element in DNA
Researchers at the MRC Weatherall Institute of Molecular Medicine’s Laboratory of Gene Regulation, led by Professor Doug Higgs and Dr. Mira Kassouf, have published a study in the journal Cell, in which they reveal another piece of the puzzle of how the code in our DNA is read.
In this study, the authors introduce the concept of “facilitators,” a newly identified type of non-coding DNA that can help to drive gene expression.
All of the cells in your body contain the same DNA. However, these cells are able to develop into over 200 different types and make up a variety of different specialized tissues such as the skin, the blood, and the brain.