Whether through genetics or training, scientists say, even mere mortals can develop extraordinary abilities.
Category: genetics – Page 161
Groundbreaking study shows how lifestyle changes can reverse biological aging
In a groundbreaking study led by Dr. Karen Fitzgerald, six women between the ages of 45 and 65 experienced a remarkable reduction in their biological age by an average of five years in just eight weeks. The findings offer promising insights into the potential of lifestyle changes to combat aging.
The study, which focused on the distinction between chronological age and biological age, revealed that while chronological age remains fixed, biological age — the age of one’s cells — can be influenced and even reversed through targeted interventions.
Using Dr. Steven Horvath’s epigenetic clock, which measures 353 markers associated with methylation changes linked to aging, the researchers assessed the participants’ biological age before and after the intervention.
‘Exhausted’ immune cells in healthy women could be target for breast cancer prevention
Everyone has BRCA1 and BRCA2 genes, but mutations in these genes—which can be inherited—increase the risk of breast and ovarian cancer.
The study found that the immune cells in breast tissue of healthy women carrying BRCA1 or BRCA2 gene mutations show signs of malfunction known as exhaustion. This suggests that the immune cells can’t clear out damaged breast cells, which can eventually develop into breast cancer.
This is the first time that exhausted immune cells have been reported in non-cancerous breast tissues at such scale—normally these cells are only found in late-stage tumors. The results raise the possibility of using existing immunotherapy drugs as early intervention to prevent breast cancer developing, in carriers of BRCA1 and BRCA2 gene mutations.
CRISPR could disable and cure HIV, suggests promising lab experiment
The gene-editing technique CRISPR disabled HIV that lay dormant in immune cells in a lab experiment, raising hopes for an eventual cure.
By Clare Wilson
Unlocking TNA: Researchers Develop Artificial Building Blocks of Life
Groundbreaking research has led to the creation of threofuranosyl nucleic acid (TNA), offering enhanced stability and therapeutic potential, with applications in drug delivery and diagnostics.
The DNA carries the genetic information of all living organisms and consists of only four different building blocks, the nucleotides. Nucleotides are composed of three distinctive parts: a sugar molecule, a phosphate group, and one of the four nucleobases adenine, thymine, guanine, and cytosine. The nucleotides are lined up millions of times and form the DNA double helix, similar to a spiral staircase.
Breakthrough in Nucleic Acid Research.
Genetic secrets from 4,000-year-old teeth illuminate the impact of changing human diets over the centuries
Researchers at Trinity College Dublin have recovered remarkably preserved microbiomes from two teeth dating back 4,000 years, found in an Irish limestone cave. Genetic analyses of these microbiomes reveal major changes in the oral microenvironment from the Bronze Age to today. The teeth both belonged to the same male individual and also provided a snapshot of his oral health.
Human brains getting larger in size, and this may be good news for some
A new study has revealed that the size of human brains is getting larger, which means increased brain reserve and decreased chances of developing dementia. The researchers at UC Davis Health reached the conclusion by comparing the size of the brains of people born in the 1930s with those of people born in the 1970s. They noticed that the latter had 6.6 per cent larger brains. The study was published in JAMA Neurology.
“The decade someone is born appears to impact brain size and potentially long-term brain health,” said Charles DeCarli, first author of the study.
He further adds that genetics may also play a major role in determining the size of the brain. “Genetics plays a major role in determining brain size, but our findings indicate external influences — such as health, social, cultural and educational factors — may also play a role,” he said.
Multiomic approach boosts disease prediction accuracy beyond traditional methods
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In a recent study published in the journal Nature Aging, researchers assessed the added predictive value of integrating polygenic risk scores (PRSs) and gut microbiome scores with conventional risk factors for common diseases in a long-term cohort study.
Analysis: Integration of polygenic and gut metagenomic risk prediction for common diseases. Image Credit: remotevfx.com / Shutterstock.
Background
Multiomic technologies are transforming disease prediction by integrating genomic and microbiomic data, offering new insights into age-related conditions like heart disease, diabetes, and cancer. Previously, risk assessments relied mainly on demographic, lifestyle, and clinical metrics. Now, the integration of PRSs and gut microbiome analysis into risk models promises to improve predictive accuracy beyond traditional factors. PRSs provide a cost-effective genetic predisposition metric, while the gut microbiome adds a novel dimension to understanding disease risk. This emerging approach necessitates further research to refine its accuracy and ensure its effectiveness across various populations and healthcare systems.