Breaking link between early, late stages of disease may prevent dementia.
Alzheimer’s disease has plagued one large Colombian family for generations, striking down half of its members in the prime of life. But one member of that family evaded what had seemed would be fate: Despite inheriting the genetic defect that caused her relatives to develop dementia in their 40s, she stayed cognitively healthy into her 70s.
Study Reveals Protective Gene Mutation
The Genetic Revolution is a compelling science documentary that invites viewers into the groundbreaking world of DNA manipulation and genetic engineering. This intriguing documentary showcases the innovative science behind genetic modifications and chronicles a diverse team of scientists from around the world as they utilize advanced DNA editing technologies like CRISPR in ways previously deemed unthinkable.\
With its exploration into the rapidly evolving science of DNA editing, \.
Primates are among the most intelligent creatures with distinct cognitive abilities. Their brains are relatively large in relation to their body stature and have a complex structure. However, how the brain has developed over the course of evolution and which genes are responsible for the high cognitive abilities is still largely unclear. The better our understanding of the role of genes in brain development, the more likely it will be that we will be able to develop treatments for serious brain diseases.
Researchers are approaching these questions by knocking out or activating individual genes and thus drawing conclusions about their role in brain development. To avoid animal experiments as far as possible, brain organoids are used as an alternative. These three-dimensional cell structures, which are only a few millimeters in size, reflect different stages of brain development and can be genetically modified. However, such modifications are usually very complex, lengthy and costly.
Researchers at the German Primate Center (DPZ)—Leibniz Institute for Primate Research in Göttingen have now succeeded in genetically manipulating brain organoids quickly and effectively. The procedure requires only a few days instead of the usual several months and can be used for organoids of different primate species. The brain organoids thus enable comparative studies of the function of genes at early stages of brain development in primates and help to better understand neurological diseases.
Full Video of the NeuroTechnolgy Center at Columbia University’s Optogenetics 2020 WebinarQ&A Transcript: tinyurl.com/yajfeozsTable of Contents:00:00:00 — In…
2023 was the year that CRISPR gene-editing sliced its way out of the lab and into the public consciousness—and American medical system. The Food and Drug Administration recently approved the first gene-editing CRISPR therapy, Casgevy (or exa-cel), a treatment from CRISPR Therapeutics and partner Vertex for patients with sickle cell disease. This comes on the heels of a similar green light by U.K. regulators in a historic moment for a gene-editing technology whose foundations were laid back in the 1980s, eventually resulting in a 2020 Nobel Prize in Chemistry for pioneering CRISPR scientists Jennifer Doudna and Emmanuelle Charpentier.
That decades-long gap between initial scientific spark, widespread academic recognition, and now the market entry of a potential cure for blood disorders like sickle cell disease that afflict hundreds of thousands of people around the world is telling. If past is prologue, even newer CRISPR gene-editing approaches being studied today have the potential to treat diseases ranging from cancer and muscular dystrophy to heart disease, birth more resilient livestock and plants that can grapple with climate change and new strains of deadly viruses, and even upend the energy industry by tweaking bacterial DNA to create more efficient biofuels in future decades. And novel uses of CRISPR, with assists from other technologies like artificial intelligence, might fuel even more precise, targeted gene-editing—in turn accelerating future discovery with implications for just about any industry that relies on biological material, from medicine to agriculture to energy.
With new CRISPR discoveries guided by AI, specifically, we can expand the toolbox available for gene editing, which is crucial for therapeutic, diagnostic, and research applications… but also a great way to better understand the vast diversity of microbial defense mechanisms, said Feng Zhang, another CRISPR pioneer, molecular biologist, and core member at the Broad Institute of MIT and Harvard in an emailed statement to Fast Company.
7 month treatment, 6 years returned according to a methylation clock, mostly in people who’s biological age was greater than their calendar age.
Dr. Brian Kennedy presents 4 molecules which show promising effects in both healthspan & lifespan in this video. https://pubmed.ncbi.nlm.nih.gov/37289866/http… https://pubmed.ncbi.nlm.nih.gov/37637… https://pubmed.ncbi.nlm.nih.gov/37925… https://pubmed.ncbi.nlm.nih.gov/35584… https://pubmed.ncbi.nlm.nih.gov/35050… https://pubmed.ncbi.nlm.nih.gov/28199… https://pubmed.ncbi.nlm.nih.gov/37904… https://pubmed.ncbi.nlm.nih.gov/37697… https://pubmed.ncbi.nlm.nih.gov/37217… https://pubmed.ncbi.nlm.nih.gov/34952… https://pubmed.ncbi.nlm.nih.gov/34847…
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ICYMI: In a groundbreaking achievement, researchers have successfully created a chimeric monkey with two different sets of DNA through the injection of stem cells from one monkey embryo into another of the same species.
[Source]
Scientists based in China have successfully created a chimeric monkey.
How they did it: A chimera is a human or an animal whose body is composed of cells that are genetically distinct. For their study, the researchers used two sets of DNA: stem cells from a cynomolgus (crab-eating macaque) monkey and a genetically distinct four-to five-day-old embryo from the same species. After implanting embryos into 40 female macaques, they recorded 12 pregnancies and six live births.
Occam’s razor—the principle that when faced with competing explanations, we should choose the simplest that fits the facts—is not just a tool of science. Occam’s razor is science, insists a renowned molecular geneticist from the University of Surrey.
In a paper published in the Annals of the New York Academy of Sciences, Professor Johnjoe McFadden argues Occam’s razor—attributed to the Surrey-born Franciscan friar William of Occam (1285–1347)—is the only feature that differentiates science from superstition, pseudoscience or fake news.
Professor McFadden said, “What is science? The rise of issues such as vaccine hesitancy, climate skepticism, alternative medicine, and mysticism reveals significant levels of distrust or misunderstanding of science among the general public. The ongoing COVID inquiry also highlights how scientific ignorance extends into the heart of government. Part of the problem is that most people, even most scientists, have no clear idea of what science is actually about.”