Lifeboat Foundation

A newly discovered type of transferable DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Great ape animal studies have long been prohibited in Europe due to ethical concerns. An alternative to using animals in studies is the use of so-called organoids, which are three-dimensional cell structures that can be generated in the lab and are just a few millimeters in size.

These organoids can be created using pluripotent stem cells, which then subsequently develop into particular cell types like nerve cells. The study team was able to create both chimpanzee and human brain organoids by using this method.

“These brain organoids allowed us to investigate a central question concerning ARHGAP11B,” says Wieland Huttner of the Max Planck Institute of Molecular Cell Biology and Genetics, one of the three lead authors of the study.

Just a quick vid. He mentions the hope of replacing current gene therapy with a pill or three which I heard Cynthia Kenyon say many years ago.

Dr David Sinclair talks about longevity genes, genes therapies and his works on resetting the eyes in this short clip.

Continue reading “That Our Body Has A MEMORY OF YOUTH Has Been Proved | Dr David Sinclair Interview Clips” »

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The CRISPR system, which involves a Cas enzyme to cut DNA, is a powerful tool for gene editing. But the genetic scissors sometimes make changes at the wrong place, creating a major safety problem that could limit their therapeutic use.

Now, scientists at the University of Texas (UT) at Austin have refined the Cas9 protein used in the Nobel Prize-winning CRISPR-Cas9 tool. The new version, dubbed SuperFi-Cas9, was thousands of times less likely to perform off-target editing but just as efficient at on-target editing as the original version, the team said in a paper published in Nature.

“This really could be a game-changer in terms of a wider application of the CRISPR-Cas systems in gene editing,” Kenneth Johnson, Ph.D., the study’s co-senior author, said in a statement.

Over the last several decades, obesity has rapidly grown to affect more than 2 billion people, making it one of the biggest contributors to poor health globally. Many individuals still have trouble losing weight despite decades of study on diet and exercise regimens. Researchers from Baylor College of Medicine and affiliated institutions now believe they understand why, and they argue that the emphasis should be shifted from treating obesity to preventing it.

The research team reports in the journal Science Advances that early-life molecular processes of brain development are likely a major determinant of obesity risk. Previous large human studies have shown that the genes most strongly associated with obesity are expressed in the developing brain. This most recent study in mice focused on epigenetic development. Epigenetics is a molecular bookmarking system that regulates whether genes are utilized or not in certain cell types.

“Decades of research in humans and animal models have shown that environmental influences during critical periods of development have a major long-term impact on health and disease,” said corresponding author Dr. Robert Waterland, professor of pediatrics-nutrition and a member of the USDA Children’s Nutrition Research Center at Baylor. “Body weight regulation is very sensitive to such ‘developmental programming,’ but exactly how this works remains unknown.”

Strange libraries of supplementary genes nicknamed “Borg” DNA appear to supercharge the microbes that possess them, giving them an uncanny ability to metabolize materials in their environment faster than their competitors.

By learning more about the way organisms use these unusual extrachromosomal packets of information, researchers are hoping to find new ways of engineering life to take a big bite out of methane emissions.

In the wake of a study publicized last year (and now published in Nature), researchers have continued to analyze the diversity of sequences methane-munching microbes store in these unusual genetic depositaries in an effort to learn more about the evolution of life.

A newly identified colon cancer gene may drive the disease by making the environment in the vicinity of tumors more hospitable to them, researchers say. The…

Dr_Microbe/iStock.

Called Upstaza, the therapy not only improved the symptoms of all participants in the small-scale trial but also gave some children the ability to walk and talk for the first time.