In Biology 101, we learn that RNA is a single, ribbon-like strand of base pairs that is copied from our DNA and then read like a recipe to build a protein. But there’s more to the story. Some RNA strands fold into complex shapes that allow them to drive cellular processes like gene regulation and protein synthesis, or catalyze biochemical reactions.
We know that these active molecules, called non-coding RNAs, are present in all life forms, yet we’re just starting to understand their many roles—and how they can be harnessed for applications in environmental science, agriculture, and medicine.
To study—and potentially modify—the functions of non-coding RNAs, we need to determine their structure. Scientists from Lawrence Berkeley National Laboratory (Berkeley Lab) and the Hebrew University of Jerusalem have developed a streamlined process that predicts the structure of an RNA molecule down to the atomic level.
A new study combining satellite imagery with genetic analysis reveals that climate and land use changes are driving increased vegetation growth in Europe’s mountain regions, ultimately leading to a decline in the genetic diversity of medicinal plants such as Greek mountain tea. Mountain regions a.
A method is developed for expressing large dystrophins to enhance muscle function in mouse models of muscular dystrophy, with potential clinical benefits for numerous disorders caused by mutations in large genes that exceed the adeno-associated virus capacity.
One of the most terrifying things about Dune is the fact that it rather accurately predicted what the next front of warfare will look like: genetic warfare. In twenty twenty five, gene manipulation is the biggest threat in the theatre of war, because one gene-altering weapon can render an enemy force infertile at best, and terribly mutated at worst. But that’s not something that happens to the products of breeding programmes in the Dune-verse, at least on a physical level. In this video, we will take a look at every breeding programme in Frank Herbert’s creation, and talk about their horrifying histories in detail.
Developmental time (or time to maturity) strongly correlates with an animal’s maximum lifespan, with late-maturing individuals often living longer. However, the genetic mechanisms underlying this phenomenon remain largely unknown. This may be because most previously identified longevity genes regulate growth rate rather than developmental time. To address this gap, we genetically manipulated prothoracicotropic hormone (PTTH), the primary regulator of developmental timing in Drosophila, to explore the genetic link between developmental time and longevity. Loss of PTTH delays developmental timing without altering the growth rate. Intriguingly, PTTH mutants exhibit extended lifespan despite their larger body size. This lifespan extension depends on ecdysone signaling, as feeding 20-hydroxyecdysone to PTTH mutants reverses the effect. Mechanistically, loss of PTTH blunts age-dependent chronic inflammation, specifically in fly hepatocytes (oenocytes). Developmental transcriptomics reveal that NF-κB signaling activates during larva-to-adult transition, with PTTH inducing this signaling via ecdysone. Notably, time-restricted and oenocyte-specific silencing of Relish (an NF-κB homolog) at early 3rd instar larval stages significantly prolongs adult lifespan while delaying pupariation. Our study establishes an aging model that uncouples developmental time from growth rate, highlighting NF-κB signaling as a key developmental program in linking developmental time to adult lifespan.
On this mind-bending episode of Impact Theory, Tom Bilyeu sits down with Ben Lamm, the visionary entrepreneur behind Colossal Biosciences, to explore a world that sounds straight out of science fiction—yet is rapidly becoming our reality. Together, they pull back the curtain on the groundbreaking technology making de-extinction not only possible, but increasingly practical, from resurrecting woolly mammoths and dire wolves to saving endangered species and unraveling the secrets of longevity.
Ben explains how CRISPR gene editing has unlocked the power to make precise DNA changes—editing multiple genes simultaneously, synthesizing entirely new genetic blocks, and pushing the limits of what’s possible in biology and conservation. The conversation dives deep into the technical hurdles, ethical questions, and the unexpected magic of re-engineering life itself, whether it’s creating hairier, “woolly” mice or tackling the colossal challenge of artificial wombs and universal eggs.
But this episode goes way beyond Jurassic Park fantasies. Tom and Ben debate the future of human health, gene selection through IVF, the specter of eugenics, global competition in biotechnology, and how AI will soon supercharge the pace of biological engineering. They even touch on revolutionary solutions to our plastic crisis and what it means to inspire the next generation of scientists.
Get ready to have your mind expanded. This is not just a podcast about bringing back extinct creatures—it’s a deep dive into the next frontiers of life on Earth, the technologies changing everything, and the choices we’ll face as architects of our own biology. Let’s get legendary.
A multi-institutional collaboration of synthetic biology research centers in China has developed a genetically engineered strain of Vibrio natriegens capable of bioremediating complex organic pollutants, including biphenyl, phenol, naphthalene, dibenzofuran, and toluene, in saline wastewater and soils.
Complex organic pollutants are prevalent in industrial wastewater generated by petroleum refining and chlor-alkali processing. Due to their chemical stability and resistance to natural degradation, these compounds persist in marine and saline environments, posing ecological risks and potential threats to public health.
Microbial bioremediation methods typically use consortia of wild-type bacterial strains, yet these organisms demonstrate limited capacity to degrade complex pollutant mixtures. Elevated salinity levels further inhibit bacterial activity, diminishing bioremediation efficacy in industrial and marine wastewater. Developing bacterial strains capable of degrading pollutants while tolerating saline conditions remains a critical challenge.
The human brain is known to contain a wide range of cell types, which have different roles and functions. The processes via which cells in the brain, particularly its outermost layer (i.e., the cerebral cortex), gradually become specialized and take on specific roles have been the focus of many past neuroscience studies.
Researchers at the University of California Los Angeles (UCLA) analyzed different datasets collected using single-cell transcriptomics, a technique to study gene expression in individual cells, to map the emergence of different cell types during the brain’s development.
Their findings, published in Nature Neuroscience, unveil gene “programs” that drive the specialization of cells in the human cerebral cortex.
Scientists have developed an AI algorithm that can identify different types of neurons from brain activity recordings with 95% accuracy—without needing genetic tools.
