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Aerobic respiration began hundreds of millions of years earlier than previously thought, study suggests

Oxygen is a vital and constant presence on Earth today. But that hasn’t always been the case. It wasn’t until around 2.3 billion years ago that oxygen became a permanent fixture in the atmosphere, during a pivotal period known as the Great Oxidation Event (GOE), which set the evolutionary course for oxygen-breathing life as we know it today. A new study by MIT researchers suggests some early forms of life may have evolved the ability to use oxygen hundreds of millions of years before the GOE. The findings may represent some of the earliest evidence of aerobic respiration on Earth.

In their study published in the journal Palaeogeography, Palaeoclimatology, Palaeoecology, MIT geobiologists traced the evolutionary origins of a key enzyme that enables organisms to use oxygen. The enzyme is found in the vast majority of aerobic, oxygen-breathing lifeforms today. The team discovered that this enzyme evolved during the Mesoarchean —a geological period that predates the Great Oxidation Event by hundreds of millions of years.

The team’s results may help to explain a longstanding puzzle in Earth’s history: Why did it take so long for oxygen to build up in the atmosphere?

Lactobacillus delbrueckii surface protein P4430 attenuates intestinal inflammation by modulating macrophage polarization via Mincle

Zhang et al. reveal that Lactobacillus del brueckii ameliorates ulcerative colitis by suppressing proinflammatory macrophages via its surface protein, P4430. This mechanism, which involves targeting the host Mincle receptor, defines a microbial strategy for combating intestinal inflammation and suggests a potential therapeutic path.

Microsoft to shut down Exchange Online EWS in April 2027

Microsoft announced today that the Exchange Web Services (EWS) API for Exchange Online will be shut down in April 2027, after nearly 20 years.

EWS is a cross-platform API for developing apps that can access Exchange mailbox items, such as email messages, meetings, and contacts, retrieved from various sources, including Exchange Online and on-premises editions of Exchange (starting with Exchange Server 2007).

Microsoft will begin blocking Exchange Online EWS by default on October 1, 2026, but administrators can temporarily maintain access via an application allowlist. The final shutdown occurs on April 1, 2027, with no exceptions granted.

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