Toggle light / dark theme

Platinum chemotherapy may cause decades’ worth of DNA changes in children’s healthy cells

The amount of DNA damage caused by certain chemotherapies used to effectively treat childhood cancer has been revealed, along with a hidden impact on the liver, paving the way for future research into new ways to mitigate these effects.

Platinum-based chemotherapy drugs are powerful at treating cancer but can have an underappreciated impact on the rest of the body. To investigate this, a team at the Wellcome Sanger Institute, the University of Cambridge, the Francis Crick Institute and King’s College London used new sequencing technologies and found distinctive DNA damage in the liver. They suggest that further research could lead to new ways to protect against this.

Published in Science, the researchers also discovered that while effectively destroying cancer cells, chemotherapy can “age” a child’s healthy cells. This results in children’s healthy cells having the same number of DNA changes that adult cells gain over many decades.

Four Spy Groups Used the Same Chrome and Windows Exploit Kit Within a Week

Multiple espionage-motivated threat activity clusters have been found deploying a previously undocumented exploit kit called BlueMoon that chains together multiple vulnerabilities in Microsoft Windows and Google Chrome.

The first in-the-wild use of BlueMoon has been attributed to the China-aligned state-sponsored group tracked as APT31 (aka Bronze Vinewood, Judgement Panda, JungleBamboo, PerplexedGoblin, RedBravo, TA412, Tide Castle, and Violet Typhoon) on August 28, 2026.

“Within days, several other espionage-motivated clusters began using BlueMoon, the majority of which have a suspected China nexus,” Proofpoint said in a report published today. “However, BlueMoon may not be exclusive to China-aligned actors, as some usage remains unattributed and there are also potentially more actors using the exploit kit.”

Around 2000, a Florida tropicalfish collector hung rescued coral fragments from underwater “trees”; the small nursery grew into a reefrestoration network

Both the deterioration of the Florida Keys reef and the response to it took time. Staghorn and elkhorn corals grew so numerous throughout the Florida Reef Tract for decades that divers reported swimming through underwater thickets.

Visual Salience Controls the Speed of Evidence Accumulation in Value-Based Decisions by Rats

Studies of visual discrimination in rodents can confound the effects of cue salience with reward value making it difficult to determine which factor guides choice behavior. We examined this issue by testing how changes in relative salience affect decision dynamics in rats (nine females and five males) performing a two-alternative forced-choice task with visual cues associated with high or low sucrose rewards. After initial training with high-and low-luminance cues, we introduced a novel cue of intermediate luminance as a “luminance shift” test. The intermediate luminance cue substituted for either the brighter or dimmer cue and had the same reward value as the replaced cue. We found that while rats maintained a preference for the higher-value option, the introduction of a perceptually more similar cue reduced choice preference and eliminated latency differences compared with baseline.

How the mouse brain learns from a single experience

Sometimes, even a single experience can be highly impactful, prompting humans and other animals to change their behavior or influencing their future choices. The formation of influential memories from a single, brief experience is also known as one-shot learning.

Researchers at Collège de France (CNRS/INSERM/Université PSL), Inria, Université Claude Bernard Lyon 1 and Brandeis University recently conducted a study investigating the neural underpinnings of one-shot learning in mice.

Their findings, published in Nature Neuroscience, suggest that one-shot learning is partly supported by endocannabinoid-mediated long-term potentiation (eCB-LTP), a lasting strengthening of communication at synapses, the junctions through which neurons exchange signals.