Toggle light / dark theme

A precise neuronal mechanism allows the brain to plan future routes to remembered goals

When humans and other animals move through familiar or unfamiliar environments, their brains rely on numerous intricate neural processes to decide which path to take next. Past studies have identified a specific population of cells in the hippocampus, a structure deep within the brain, that appears to play a key role in spatial navigation.

These cells, called place cells, become active when an animal either visits or thinks about a specific location. Place cells often fire in rapid sequences during so-called theta oscillations (i.e., rhythmic brain activity patterns that cycle approximately 4–12 times per second). These rapid bursts of sequential place cell activity, also known as theta sweeps, were previously associated with the mental evaluation of possible future routes.

Two distinct research teams based at Cornell University and University College London recently shed new light on the contribution of theta sweeps to spatial navigation.

First mRNA flu shot approved by FDA bodes well for improving drugs of the future few hurdles remain before mRNA can move beyond vaccines

From COVID-19 vaccines to Moderna’s mRNA flu vaccine, using mRNA as medicine has shown promise. But before mRNA drugs can go beyond vaccines, researchers need to identify the right diseases to treat.

Frequency and Causes of Hospital ReAdmissions among PostKidney Transplant Recipients at Specialized Centers in Khartoum, Sudan A CrossSectional Study

Abstract

Background: Hospital readmissions after kidney transplantation are common and may predict future adverse outcomes. Previous studies using claims data have been limited. A better understanding of the risk factors associated with readmissions is necessary to develop accurate predictive models. Objective and Rationale: To determine the frequency, causes, and duration of hospital readmissions among post-kidney transplant recipients in specialized centers in Khartoum State, Sudan. Study Design: A descriptive, cross-sectional study. Setting and Participants: Three hundred post-kidney transplant recipients at Ahmed Gasim and Ibn Sina centers were enrolled in this study. Data on recipient, donor, and transplantation characteristics were collected. Readmission frequency, duration, causes, sites, and length of hospital stay were recorded using structured questionnaires and medical record reviews. Results: The hospital readmission rate was 39% (n = 117). Of these, 72.6% (n = 85) were readmitted only once, and infection was the leading cause of readmissions. Recipient male gender (P-value = 0.031), high body mass index (P-value = 0.014), chronic lung diseases and diabetes mellitus among comorbidities (P-value = 0.000), prior dialysis before kidney transplantation, especially peritoneal dialysis and peritoneal combined hemodialysis (P-value = 0.003), missed post-transplantation follow-up (P-value = 0.000), older-aged donor above 60 years (P-value = 0.003), kidney transplantation from second-degree related donors (P-value = 0.034), and intermediate & high immunological risks (P-value = 0.000) were major predisposing factors for hospital readmission post kidney transplantation. Conclusion: The hospital readmission rate after kidney transplantation among Sudanese recipients was high and mainly due to infection; a specific preventive program based on infection prevention and graft function monitoring should be established.

Post-Kidney Transplant Recipients, Hospital Readmission, Sudan

/* */