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Microbes living in our guts help us digest food by reshaping the bile acids that our livers produce for breaking down fats. It turns out that two of these microbially-modified bile acids may affect our risk—in opposite directions—for developing colon cancer.

The link between these bile acids and colon cancer risk was recently uncovered as University of Wisconsin–Madison scientists sought to better understand the relationship between gut microbes and our bodies.

In many ways, that relationship revolves around a specific protein called the farnesoid X receptor, or FXR, which helps maintain a healthy gut through its intimate relationship with bile acids. FXR controls the production of bile acids in the liver, but it also responds in different ways to the presence of various bile acids that microbes have modified.

Using digital blueprints of the metabolism of microbes, scientists can simulate expensive and time-intensive experiments set in space, power plants and farm fields.

Scientists at the University of Alberta found a new way to improve plant-based foods, and it involves plasma, the same stuff that makes up stars, as reported by Phys.org.

The breakthrough makes 3D-printed pea protein hold its shape, opening doors for more affordable and tasty meat alternatives.

Pea protein is already in many foods we eat, from bread to dairy-free milk to meatless burgers. It’s cheap and packed with nutrients, but until now, it wouldn’t keep its shape when pushed through a 3D printer, limiting its use in food production.

A team of materials scientists, physicists, mechanical engineers, and molecular physiologists at Stanford University have developed a nanoparticle technique that can be used to measure force dynamics inside a living creature, such as Caenorhabditis elegans worms biting their food.

In their paper published in the journal Nature, the group describes how they used to excite luminescent nanocrystals in a way that allowed the energy levels of cells inside a C. elegans worm to be measured.

Andries Meijerink, with Utrecht University, has published a News & Views piece in the same journal issue, outlining the work done by the team in California.

Sensitive cells: Scientists discovered dozens of specific cell types, mostly glial cells, known as brain support cells, that underwent significant gene expression changes with age. Those strongly affected included microglia and border-associated macrophages, oligodendrocytes, tanycytes, and ependymal cells.

Inflammation and neuron protection: In aging brains, genes associated with inflammation increased in activity while those related to neuronal structure and function decreased.

Aging hot spot: Scientists discovered a specific hot spot combining both the decrease in neuronal function and the increase in inflammation in the hypothalamus. The most significant gene expression changes were found in cell types near the third ventricle of the hypothalamus, including tanycytes, ependymal cells, and neurons known for their role in food intake, energy homeostasis, metabolism, and how our bodies use nutrients. This points to a possible connection between diet, lifestyle factors, brain aging, and changes that can influence our susceptibility to age-related brain disorders.

Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice.


Year 2023 I have found both spiders and bees are sentient because their emotional intelligence is very high much like a human child.


‘Fringe’ research suggests the insects that are essential to agriculture have emotions, dreams and even PTSD, raising complex ethical questions.

Research led by Zhejiang Agriculture and Forestry University in China has performed a metadata investigation into the presence of microplastics in humans. They report a concerning relationship between micro and nanoplastic (MNP) concentrations in damaged tissues and links with multiple health conditions.

Plastic usage soared from 1.5 million metric tons in the 1950s to nearly 390.7 million in 2021. With the increased use in came elevated microscopic plastic pollution circulating in soil and waterways, eventually accumulating in the environment, food webs and human tissues.

Consistent methods to pinpoint and quantify MNPs in human tissues are lacking. Reliable data linking MNPs to human diseases are necessary for assessing potential risks and developing mitigation measures.

The work-related death rate fell 95% in the U.S. between 1913 & 2015.

Labor union activism is often credited with the decline, but economic expansion is what made better working conditions possible in the first place.

Read more about this trend.


All economic activity involves some degree of physical risk. Credible data on work injuries and fatalities among our agrarian ancestors are difficult to come by. Yet agricultural work must have been quite unappealing, considering that so many people in the early 19th century preferred factory work over farm work.