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David Sinclair on Aging and How we can reset our age

Good talk, not just about NAD. Q&A just before 35 minutes. A lot of epigenetics here.


David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 16 years. His research has been primarily focused on the sirtuins, protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction (CR) with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer. The Sinclair lab was the first one to identify a role for NAD+ biosynthesis in regulation of lifespan and first showed that sirtuins are involved in CR in mammals. They first identified small molecules that activate SIRT1 such as resveratrol and studied how they improve metabolic function using a combination of genetic, enzymological, biophysical and pharmacological approaches. They recently showed that natural and synthetic activators require SIRT1 to mediate the in vivo effects in muscle and identified a structured activation domain. They demonstrated that miscommunication between the mitochondrial and nuclear genomes is a cause of age-related physiological decline and that relocalization of chromatin factors in response to DNA breaks may be a cause of aging.

How the pandemic fast-tracked this multibillion-dollar industry | Make It International

The coronavirus pandemic has been a real learning curve, not least for educators. But with many schools now reopening, questions are being asked about what the future of education might look like. CNBC Make It’s Karen Gilchrist spoke to entrepreneurs in India, Hong Kong and the U.S. to learn more about the multibillion-dollar business opportunity.

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Have humans reached the end of evolution? Not under these 4 scenarios

3. Evolution shifts to off-world human colonies.

4. Transhumanism will drive evolution.


Is natural selection still a major force in human evolution? As far back as high school biology, we’ve been taught to think the answer must be yes. But is it really true?

Charles Darwin published his groundbreaking On the Origin of Species back in 1859, around the same time that Charles Dickens was making a name for himself writing about social conditions in England. Dickens’ stories emerge from a period in which only 50 percent of British children survived to adulthood — a number not so different from animals in the jungle. In that vein, Darwin was right when he said natural selection was operating on humans full force.

Yet the forces that came into play in the 1850s are far different from those we experience today, prompting some high profile biologists to suggest that our advanced medical capabilities have, in effect, blunted natural selection. In a 2013 Radio Times interview, science communicator David Attenborough described it this way:

Alien Carnivorous Frog Invasion Wreaks Havoc on Natural Habitat

“The state government should consider managing the invasive population of spotted-thighed frogs at Streaky Bay. This should include education programs to inform people about what to do if they find a frog, as well as the feasibility of exterminating the population in South Australia.

“Importantly, if you do see one of these critters in your travels – leave it be. We don’t want it hitchhiking any further.”

Reference: ” Indiscriminate feeding by an alien population of the spotted-thighed frog (Litoria cyclorhyncha) in southern Australia and potential impacts on native biodiversity” by Christine M. Taylor, Gunnar Keppel, Shaun O’Sullivan, Stefan Peters, Gregory D. Kerr and Craig R. Williams, 9 April 2020, Australian Journal of Zoology. DOI: 10.1071/ZO19042

Putin orders creation of national genetic database as Russia prioritizes genetic research

The president also ordered a boost in the education of specialists in genetics and genome sequencing and the domestic production of necessary laboratory equipment, as well as tax cuts for biomedical research. Russia will also open world-class genome research centers which will, among their immediate goals, work on the development of treatments and vaccines for Covid-19.


The future database will be one of the tools that Russia hopes to use to assume a leading position in the biomedical industry. The government sees it as crucial for keeping the country competitive on the world stage going forward.

The Kurchatov Institute, which is best known for nuclear research, has been tasked with laying the foundation for the database, choosing the storage format and making tools for search and analysis. The institute has experience in the secure handling of large amounts of sensitive data and operates a number of data centers across Russia which are used for scientific collaboration projects.

The pandemic is challenging China’s breakneck race to the top of science

Like all countries, China is facing severe economic losses from the pandemic, and that will certainly have a negative impact on scientific research, because funding will be reduced and projects will be delayed, says physicist Wang Yifang, director of the Institute of High Energy Physics in Beijing. Some universities have already announced a cut in funding. The research budget given by the education ministry to Jiangnan University in Wuxi, for example, will drop by more than 25% for 2020, and other universities are facing similar reductions. “An overall budget cutting of government spending on higher education is highly possible, though the level and scope may vary by regions, universities and fields,” says Tang Li, a science-policy scientist at Fudan University in Shanghai.


The country is rapidly gaining on the United States in research, but problems could slow its rise: part 5 in a series on science after the pandemic.

Chasing immortality | The Future is Now

#Eternal life might not be attainable in the near future, but genetic engineers and doctors are working on new life extension technology. The research could lead to keeping our bodies young, and scientists are developing ways of downloading our brain’s consciousness onto digital media once the body is at the end of its life cycle.

#RT #Documentary offers you in-depth documentary films on topics that will leave no one indifferent. It’s not just front-page stories and global events, but issues that extend beyond the headlines. Social and environmental issues, shocking traditions, intriguing personalities, history, sports and so much more – we have documentaries to suit every taste. RTD’s film crews travel far and wide to bring you diverse and compelling stories. Discover the world with us!

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Dr. Michael R. Rose presents “Biological Immortality is REAL”

Dr. Michael R. Rose is Professor at Department of Ecology and Evolutionary Biology at University Of California, Irvine. His main area of work has been the evolution of aging.
“Our task is to make nature, the blind force of nature, into an instrument of universal resuscitation and to become a union of immortal beings.“
- Nikolai F. Fedorov

We hold faith in the technologies & discoveries of humanity to END AGING and Defeat involuntary Death within our lifetime.

Working to Save Lives with Age Reversal Education.

========== Perpetual Life Creed ==========

We believe that all of life is sacred and that we have been given this one life to make unlimited. We believe in our Creator’s divine plan for all of humanity to have infinite lifespans in perfect health and eternal joy, rendering death to be optional.

By following our Gospel we achieve eternal life creating a heaven here on earth.

How Do Quantum States Manifest In The Classical World?

Education Saturday with Space Time.


This episode of space time is brought to you by the information flowing through an impossibly complex network of quantum entanglement, that just happens to mutually agree that you and I exist inside it. Oh, and Schrodinger’s cat is in here too.

In quantum world things are routinely in multiple states at once – what we call a “superposition” of states. But in the classical world of large scales, things are either this or that. The famous thought experiment is Schrodinger’s cat – in which a cat is in an opaque box with a vial of deadly poison that’s released on the radioactive decay of an atom. Quantum mechanics tells us that the atom’sfunction can be in a superposition of states – simultaneously decayed or not decayed. So is the cat’sfunction also in a superposition of both dead and alive.