Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: computing – Page 437

Combating Antibiotic-Resistant Bacteria — Dr. Erin Duffy, Ph.D., Chief of Research & Development, and Kevin Outterson, ESQ., Executive Director, CARB-X.

The Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X — https://carb-x.org/) is a global non-profit partnership accelerating antibacterial products to address drug-resistant bacteria, a leading cause of death around the world. 1.27 million deaths worldwide were attributed to resistant bacterial infections in 2019.

The CARB-X portfolio is the world’s most scientifically diverse, early development pipeline of new antibiotics, vaccines, rapid diagnostics and other products and represents the only global partnership that integrates solutions for the prevention, diagnosis and treatment of life-threatening bacterial infections, translating innovation from basic research to first-in-human clinical trials.

Dr. Erin Duffy, PhD., is Chief of Research & Development at CARB-X and she has two decades of drug-discovery and problem-solving experience in the antibiotic arena. She was previously with Rib-X Pharmaceuticals (now Melinta Therapeutics) where in increasing roles she helped to build and sustain a team of researchers that translated the company’s scientific platform into next-generation and novel antibiotics that target the ribosome. Her team’s most recent achievements include the de novo design and optimization of a completely new class of antibiotics, the pyrrolocytosines, which were supported in part by CARB-X. Prior to Rib-X, Erin was the Associate Director of Innovative Discovery Technologies at Achillion Pharmaceuticals, responsible for building the structure and computational teams and platform for their antiviral efforts. She began her industrial career at Pfizer Central Research, in Groton, Connecticut, where she joined a team of computational and structural drug designers in multiple therapeutic areas. Erin was trained formally at Yale University, where she became a physical-organic chemist focused on defining computationally how small molecules interact and react in the group of Professor William L. Jorgensen. She expanded her experience to large molecules under the mentorship of Professor Axel Brunger, whose group at Yale was transitioning to a mix of computational and laboratory structural biology.

Kevin Outterson, ESQ., is Executive Director of CARB-X and is a global thought leader on business models for antibiotic development and use. He is Professor of Law and N. Neil Pike Scholar of Health and Disability Law at Boston University School of Law, where he leads multi-disciplinary teams to solve global health issues. Professor Outterson is the Executive Director and Principal Investigator of CARB-X and a partner in DRIVE-AB (aka Driving Reinvestment In Research And Development And Responsible Antibiotic Use) a project composed of 15 public and 7 private partners from 12 countries that is funded by the Innovative Medicines Initiative (IMI) joint undertaking between the European Union and the European Pharmaceutical Industry Association (EFPIA). He also leads the Social Innovation on Drug Resistance program at Boston University.

Continue reading “Dr. Erin Duffy, Ph.D. & Kevin Outterson, ESQ — Combating Antibiotic-Resistant Bacteria (CARB-X)” | >

The brain is inarguably the single most important organ in the human body. It controls how we move, react, think and feel, and enables us to have complex emotions and memories. The brain is composed of approximately 86 billion neurons that form a complex network. These neurons receive, process, and transfer information using chemical and electrical signals.

Learning how respond to different signals can further the understanding of cognition and development and improve the management of disorders of the brain. But experimentally studying neuronal networks is a complex and occasionally invasive procedure. Mathematical models provide a non-invasive means to accomplish the task of understanding , but most current models are either too computationally intensive, or they cannot adequately simulate the different types of complex neuronal responses. In a recent study, published in Nonlinear Theory and Its Applications, IEICE, a research team led by Prof. Tohru Ikeguchi of Tokyo University of Science, has analyzed some of the complex responses of neurons in a computationally simple neuron model, the Izhikevich neuron model.

“My laboratory is engaged in research on neuroscience and this study analyzes the basic mathematical properties of a neuron model. While we analyzed a single neuron model in this study, this model is often used in computational neuroscience, and not all of its properties have been clarified. Our study fills that gap,” explains Prof. Ikeguchi. The research team also comprised Mr. Yota Tsukamoto and Ph.D. student Ms. Honami Tsushima, also from Tokyo University of Science.

Read more | >

Scientists from Beijing set a new quantum secure direct communication (QSDC) world record of 102.2 km (64 miles), a massive leap over the previous record of 18 km (11 miles), according to The Eurasian Times.

The research could eventually lead to a massive quantum communications network that would be virtually hacker-proof due to the nature of the technology.

The researchers, who published their findings in a paper in Nature, demonstrated transmission speeds of 0.54 bits per second, much slower than communications using classical computing devices. Still, this was fast enough for phone call and text message encryption over a distance of 30 km (19 miles).

Read more | >

Summary: The Izhikevich neuron model allows the simulation of both periodic and quasi-periodic responses in neurons at lower computational cost.

Source: Tokyo University of Science.

The brain is inarguably the single most important organ in the human body. It controls how we move, react, think and feel, and enables us to have complex emotions and memories. The brain is composed of approximately 86 billion neurons that form a complex network. These neurons receive, process, and transfer information using chemical and electrical signals.

Read more | >

Scientists from the National Synchrotron Light Source II (NSLS-II) and Computational Science Initiative (CSI) at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory have helped to solve a common problem in synchrotron X-ray experiments: reducing the noise, or meaningless information, present in data. Their work aims to improve the efficiency and accuracy of X-ray studies at NSLS-II, with the goal of enhancing scientists’ overall research experience at the facility.

NSLS-II, a DOE Office of Science user facility, produces X-ray beams for the study of a huge variety of samples, from potential new battery materials to plants that can remediate contaminated soil. Researchers from across the nation and around the globe come to NSLS-II to investigate their samples using X-rays, collecting huge amounts of data in the process. One of the many X-ray techniques available at NSLS-II to visiting researchers is X-ray photon correlation spectroscopy (XPCS). XPCS is typically used to study material behaviors that are time-dependent and take place at the nanoscale and below, such as the dynamics between and within structural features, like tiny grains. XPCS has been used, for example, to study magnetism in advanced computing materials and structural changes in polymers (plastics).

While XPCS is a powerful technique for gathering information, the quality of the data collected and range of materials that can be studied is limited by the “flux” of the XPCS X-ray beam. Flux is a measure of the number of X-rays passing through a given area at a point in time, and high flux can lead to too much “noise” in the data, masking the signal the scientists are seeking. Efforts to reduce this noise have been successful for certain experimental setups. But for some types of XPCS experiments, achieving a more reasonable signal-to-noise ratio is a big challenge.

Read more | >

In a discovery that could speed research into next-generation electronics and LED devices, a University of Michigan research team has developed the first reliable, scalable method for growing single layers of hexagonal boron nitride on graphene.

The process, which can produce large sheets of high-quality hBN with the widely used molecular-beam epitaxy process, is detailed in a study in Advanced Materials.

Graphene-hBN structures can power LEDs that generate deep-UV light, which is impossible in today’s LEDs, said Zetian Mi, U-M professor of and and a corresponding author of the study. Deep-UV LEDs could drive smaller size and greater efficiency in a variety of devices including lasers and air purifiers.

Read more | >

Mushrooms could be communicating in a structure that resembles human language, suggests a study published in the Royal Society Open Science.

Professor Andrew Adamatzky analysed the electrical signals in fungi and found patterns that have a structural similarity to English and Swedish languages at the University of the West of England’s Unconventional Computing Laboratory. The hope is to better understand how information is transferred and processed in mycelium networks, and to one day create fungi-based computing devices.

Read more | >

Around the rim of the lens is an array of other electronics, including a custom-designed chip with a radio that streams content to the display and a variety of sensors, including an accelerometer, gyroscope, and magnetometer for tracking the user’s eye movements. This eye tracking capability not only ensures that AR imagery holds still as the user looks around, but also makes it possible to control the device through eye movements alone.

Despite their efforts to pack as much into the lens as possible, it won’t be a stand-alone piece of equipment. Most of the computing power required to run AR applications will be contained in a companion device worn around the neck, which will stream the content to the lens wirelessly.

The lens also hasn’t yet been cleared by the FDA for human use, so early demonstrations involve looking through a lens on a stick just in front of the eye. At present it is only capable of producing images in a green monochrome. But according to CNET , the device allows a user to select a variety of apps arranged in a ring around the periphery of their field of vision using nothing more than their gaze. These make it possible to do everything from checking flight information to using a compass to navigate and track fitness data like heart rate and lap number.

Read more | >

To fully embrace the benefits of quantum computing in the future, we need to focus on education and workforce development and become quantum-ready today.

The 13-year-old daughter of a friend visiting my workplace — the IBM Research lab in Zurich — seemed puzzled. She knew I worked in a research lab and I that work with computers, but the computers she knows don’t typically resemble the chandelier-like structure that hung from the ceiling in front of us.

Yet, it is a computer – a quantum computer. And while someone in their early teens right now can be excused for not knowing what a quantum computer is, I would very much like that to change.

Read more | >