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The Science of Keeping Your Chips Cool

All of the cooling methods we’ve discussed so far work by the simple transfer of heat from a hot chip to the surrounding air. This means a chip can never get colder than the ambient temperature of the room it’s in. If we want to cool below ambient temperatures, or if we need to cool something massive like an entire data center, we need to apply some additional science. This is where chillers and thermoelectric coolers come in.

Thermoelectric cooling, also known as a Peltier device, is not very popular at the moment but has the potential to become very useful. These devices transfer heat from one side of a cooling plate to the other by consuming electricity. They use special thermoelectric materials that can create a temperature difference via an electric potential.

When a DC current flows through the device, heat is absorbed from one side and transferred to the other, allowing the “cool” side to drop below ambient temperature. Currently, these devices remain niche because they require a lot of energy to achieve significant cooling. However, researchers are working to develop more efficient versions for broader use.

Blaise Agüera y Arcas and Michael Levin: The Computational Foundations of Life and Intelligence

In this remarkable conversation, Michael Levin (Tufts University) and Blaise Agüera y Arcas (Google) examine what happens when biology and computation collide at their foundations. Their recent papers—arriving simultaneously yet from distinct intellectual traditions—illuminate how simple rules generate complex behaviors that challenge our understanding of life, intelligence, and agency.

Michael’s \

History of Brain-Computer Interfaces | Neuralink — DJ Seo and Lex Fridman

Lex Fridman Podcast full episode: https://www.youtube.com/watch?v=Kbk9BiPhm7o.
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GUEST BIO:
Elon Musk is CEO of Neuralink, SpaceX, Tesla, xAI, and CTO of X. DJ Seo is COO & President of Neuralink. Matthew MacDougall is Head Neurosurgeon at Neuralink. Bliss Chapman is Brain Interface Software Lead at Neuralink. Noland Arbaugh is the first human to have a Neuralink device implanted in his brain.

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Brain-Computer Interface: No Open Brain Surgery Required 🧠

Synchron has developed a Brain-Computer Interface that uses pre-existing technologies such as the stent and catheter to allow insertion into the brain without the need for open brain surgery.

Read the CNET article for more info:
You Might Not Need Open Brain Surgery to Get Mind Control https://cnet.co/3sZ7k67

0:00 Intro.
0:25 History of Brain Chip Implants.
0:44 About Synchron.
0:54 How Synchron implants the interface.
1:55 How brain patterns transmit signals.
2:50 Risks and Concerns.
3:50 Patients and Clinical Testing.
4:25 Brain Health Monitoring.
5:04 Synchron Switch Price.

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#WhatTheFuture #Synchron #BCI

Tool for tracking antibiotic resistance genes

The global proliferation of antibiotic resistance genes (ARGs) poses a significant threat to the efficacy of antibiotic-based treatments for diseases. Effective monitoring of ARGs across both spatial and temporal dimensions is essential to understanding their transmission and implementing preventive measures.

A research team has developed a computational tool, Argo, designed to accurately track ARGs in environmental samples, providing insights into their dissemination and associated risks.

“Short-read sequencing method is currently used as a high-throughput DNA sequencing technique that generates large volumes of short DNA fragments, typically 150 base pairs. However, it often fails to provide information on the hosts of ARGs,” explained the senior author. “Without detailed host information, it becomes challenging to accurately assessing the risks of ARGs and tracing their transmission, hindering our understanding of their impact on human health and the environment.”

Saturday Citations: Is the universe a computational process? Plus: Psychological benefits of gaming

This week, researchers uncovered the negative pressure mechanisms plants use to communicate stress. Linguists found that the melody of spoken language in English functions as its own, distinct language. And there was also depressing news! Like the Trump administration slashing NASA’s budget, which could scrap the James Webb Space Telescope right at the beginning of its operational life (they’re also pushing to scrap the completed Nancy Grace Roman Space Telescope before its launch).

Additionally, researchers found that the video game Dark Souls has positive psychological effects on players; a physicist made a new contribution to the theory that the universe is a computational process; and scientists in Spain mapped the brain connectivity patterns of psychosis patients:

Simulating multilayered protein condensates support learning and memory

Our brain’s remarkable ability to form and store memories has long fascinated scientists, yet most of the microscopic mechanisms behind memory and learning processes remain a mystery. Recent research points to the importance of biochemical reactions occurring at postsynaptic densities—specialized areas where neurons connect and communicate. These tiny junctions between brain cells are now thought to be crucial sites where proteins need to organize in specific ways to facilitate learning and memory formation.

More specifically, a 2021 study revealed that memory-related proteins can bind together to form droplet-like structures at postsynaptic densities. What makes these structures particularly intriguing is their unique “droplet-inside-droplet” organization, which scientists believe may be fundamental to how our brains create lasting memories. However, understanding exactly how and why such complex protein arrangements form has remained a significant challenge in neuroscience.

Against this backdrop, a research team has developed an innovative computational model that reproduces these intricate protein structures. Their paper, published online in Cell Reports, explores the mechanisms behind the formation of multilayered protein condensates.