The Future of Skunkworks Management, Now! By Mr. Andres Agostini This is an excerpt from the conclusion section of, “…The Future of Skunkworks Management, Now!…” that discusses some management theories and practices and strategies. To view the entire piece, just click the link at the end of this post: Peter Drucker asserted, “…In a few hundred years, when the story of our [current] time is written from a long-term perspective, it is likely that the most important event those historians will see is not technology, not the Internet, not e-commerce [not so-called ‘social media’]. IT is an unprecedented change in the human condition. For the first time ─ literally ─ substantial and growing numbers of people have choices. for the first time, they will have to manage themselves. And society is totally unprepared for it…” Please see the full presentation at http://goo.gl/FnJOlg
This is an excerpt from the conclusion section of, “…NASA’s Managerial and Leadership Methodology, Now Unveiled!..!” by Mr. Andres Agostini, that discusses some management theories and practices. To read the entire piece, just click the link at the end of this illustrated article and presentation:
In addition to being aware and adaptable and resilient before the driving forces reshaping the current present and the as-of-now future, there are some extra management suggestions that I concurrently practice:
1. Given the vast amount of insidious risks, futures, challenges, principles, processes, contents, practices, tools, techniques, benefits and opportunities, there needs to be a full-bodied practical and applicable methodology (methodologies are utilized and implemented to solve complex problems and to facilitate the decision-making and anticipatory process).
The manager must always address issues with a Panoramic View and must also exercise the envisioning of both the Whole and the Granularity of Details, along with the embedded (corresponding) interrelationships and dynamics (that is, [i] interrelationships and dynamics of the subtle, [ii] interrelationships and dynamics of the overt and [iii] interrelationships and dynamics of the covert).
Both dynamic complexity and detail complexity, along with fuzzy logic, must be pervasively considered, as well.
To this end, it is wisely argued, “…You can’t understand the knot without understanding the strands, but in the future, the strands need not remain tied up in the same way as they are today…”
For instance, disparate skills, talents, dexterities and expertise won’t suffice ever. A cohesive and congruent, yet proven methodology (see the one above) must be optimally implemented.
Subsequently, the Chinese proverb indicates, “…Don’t look at the waves but the currents underneath…”
2. One must always be futurewise and technologically fluent. Don’t fight these extreme forces, just use them! One must use counter-intuitiveness (geometrically non-linearly so), insight, hindsight, foresight and far-sight in every day of the present and future (all of this in the most staggeringly exponential mode). To shed some light, I will share two quotes.
The Panchatantra (body of Eastern philosophical knowledge) establishes, “…Knowledge is the true organ of sight, not the eyes.…” And Antonio Machado argues, “… An eye is not an eye because you see it; an eye is an eye because it sees you …”
Managers always need a clear, knowledgeable vision. Did you already connect the dots stemming from the Panchatantra and Machado? Did you already integrate those dots into your big-picture vista?
As side effect, British Prime Minister W. E. Gladstone considered, “…You cannot fight against the future…”
3. In all the Manager does, he / she must observe and apply, at all times, a sine qua non maxim, “…everything is related to everything else…”
4. Always manage as if it were a “project.” Use, at all times, the “…Project Management…” approach.
5. Always use the systems methodology with the applied omniscience perspective.
In this case, David, I mean to assert: The term “Science” equates to about a 90% of “…Exact Sciences…” and to about 10% of “…Social Sciences…” All science must be instituted with the engineering view.
6. Always institute beyond-insurance risk management as you boldly integrate it with your futuring skill / expertise.
7. In my firmest opinion, the following must be complied this way (verbatim): the corporate strategic planning and execution (performing) are a function of a grander application of beyond-insurance risk management. It will never work well the other way around. Transformative and Integrative Risk Management (TAIRM) is the optimal mode to do advanced strategic planning and execution (performing).
TAIRM is not only focused on terminating, mitigating and modulating risks (expenses of treasure and losses of life), but also concentrated on bringing under control fiscally-sound, sustainable organizations and initiatives.
TAIRM underpins sensible business prosperity and sustainable growth and progress.
8. I also believe that we must pragmatically apply the scientific method in all we manage to the best of our capacities.
If we are “…MANAGERS…” in a Knowledge Economy and Knowledge Era (not a knowledge-driven eon because of superficial and hollow caprices of the follies and simpletons), we must do therefore extensive and intensive learning and un-learning for Life if we want to succeed and be sustainable.
As a consequence, Dr. Noel M. Tichy, PhD. argues, “…Today, intellectual assets trump physical assets in nearly every industry…”
Consequently, Alvin Toffler indicates, “…In the world of the future, THE NEW ILLITERATE WILL BE THE PERSON WHO HAS NOT LEARNED TO LEARN…”
We don’t need to be scientists to learn some basic principles of advanced science.
Accordingly, Dr. Carl Sagan, PhD. expressed, “…We live in a society exquisitely dependent on science and technology, in which hardly anyone knows about science and technology…” And Edward Teller stated, “…The science of today is the technology of tomorrow …”
And it is also crucial this quotation by Winston Churchill, “…If we are to bring the broad masses of the people in every land to the table of abundance, IT CAN ONLY BE BY THE TIRELESS IMPROVEMENT OF ALL OF OUR MEANS OF TECHNICAL PRODUCTION…”
I am not a scientist but I tirelessly support responsible scientists and science. I like scientific and technological knowledge and methodologies a great deal.
Chiefly, I am a college autodidact made by his own self and engaged into extreme practical and theoretical world-class learning for Life.
9. In any management undertaking, and given the universal volatility and rampant and uninterrupted rate of change, one must think and operate in a fluid womb-to-tomb mode.
The manager must think and operate holistically (both systematically and systemically) at all times.
The manager must also be: i) Multidimensional, ii) Interdisciplinary, iii) Multifaceted, iv) Cross-functional, and v) Multitasking.
That is, the manager must now be an expert state-of-the-art generalist and erudite. ERGO, THIS IS THE NEWEST SPECIALIST AND SPECIALIZATION.
Managers must never manage elements, components or subsystems separately or disparately (that is, they mustn’t ever manage in series).
Managers must always manage all of the entire system at the time (that is, managing in parallel or simultaneously the totality of the whole at once).
10. In any profession, beginning with management, one must always and cleverly upgrade his / her learning and education until the last exhale.
An African proverb argues, “…Tomorrow belongs to the people who prepare for it…” And Winston Churchill established, “…The empires of the future are the empires of the mind…” And an ancient Chinese Proverb: “…It is not our feet that move us along — it is our minds…” And Malcolm X observed, “…The future belongs to those who prepare for it today…” And Leonard I. Sweet considered, “…The future is not something we enter. The future is something we create…”
And finally, James Thomson argued, “…Great trials seem to be a necessary preparation for great duties …”
Consequently, Dr. Gary Hamel, PhD. indicates, “…What distinguishes our age from every other is not the world-flattening impact of communications, not the economic ascendance of China and India, not the degradation of our climate, and not the resurgence of ancient religious animosities. RATHER, IT IS A FRANTICALLY ACCELERATING PACE OF CHANGE…”
In this essay I argue that technologies and techniques used and developed in the fields of Synthetic Ion Channels and Ion Channel Reconstitution, which have emerged from the fields of supramolecular chemistry and bio-organic chemistry throughout the past 4 decades, can be applied towards the purpose of gradual cellular (and particularly neuronal) replacement to create a new interdisciplinary field that applies such techniques and technologies towards the goal of the indefinite functional restoration of cellular mechanisms and systems, as opposed to their current proposed use of aiding in the elucidation of cellular mechanisms and their underlying principles, and as biosensors.
In earlier essays (see here and here) I identified approaches to the synthesis of non-biological functional equivalents of neuronal components (i.e. ion-channels ion-pumps and membrane sections) and their sectional integration with the existing biological neuron — a sort of “physical” emulation if you will. It has only recently come to my attention that there is an existing field emerging from supramolecular and bio-organic chemistry centered around the design, synthesis, and incorporation/integration of both synthetic/artificial ion channels and artificial bilipid membranes (i.e. lipid bilayer). The potential uses for such channels commonly listed in the literature have nothing to do with life-extension however, and the field is to my knowledge yet to envision the use of replacing our existing neuronal components as they degrade (or before they are able to), rather seeing such uses as aiding in the elucidation of cellular operations and mechanisms and as biosensors. I argue here that the very technologies and techniques that constitute the field (Synthetic Ion-Channels & Ion-Channel/Membrane Reconstitution) can be used towards the purpose of the indefinite-longevity and life-extension through the iterative replacement of cellular constituents (particularly the components comprising our neurons – ion-channels, ion-pumps, sections of bi-lipid membrane, etc.) so as to negate the molecular degradation they would have otherwise eventually undergone.
While I envisioned an electro-mechanical-systems approach in my earlier essays, the field of Synthetic Ion-Channels from the start in the early 70’s applied a molecular approach to the problem of designing molecular systems that produce certain functions according to their chemical composition or structure. Note that this approach corresponds to (or can be categorized under) the passive-physicalist sub-approach of the physicalist-functionalist approach (the broad approach overlying all varieties of physically-embodied, “prosthetic” neuronal functional replication) identified in an earlier essay.
The field of synthetic ion channels is also referred to as ion-channel reconstitution, which designates “the solubilization of the membrane, the isolation of the channel protein from the other membrane constituents and the reintroduction of that protein into some form of artificial membrane system that facilitates the measurement of channel function,” and more broadly denotes “the [general] study of ion channel function and can be used to describe the incorporation of intact membrane vesicles, including the protein of interest, into artificial membrane systems that allow the properties of the channel to be investigated” [1]. The field has been active since the 1970s, with experimental successes in the incorporation of functioning synthetic ion channels into biological bilipid membranes and artificial membranes dissimilar in molecular composition and structure to biological analogues underlying supramolecular interactions, ion selectivity and permeability throughout the 1980’s, 1990’s and 2000’s. The relevant literature suggests that their proposed use has thus far been limited to the elucidation of ion-channel function and operation, the investigation of their functional and biophysical properties, and in lesser degree for the purpose of “in-vitro sensing devices to detect the presence of physiologically-active substances including antiseptics, antibiotics, neurotransmitters, and others” through the “… transduction of bioelectrical and biochemical events into measurable electrical signals” [2].
Thus my proposal of gradually integrating artificial ion-channels and/or artificial membrane sections for the purpse of indefinite longevity (that is, their use in replacing existing biological neurons towards the aim of gradual substrate replacement, or indeed even in the alternative use of constructing artificial neurons to, rather than replace existing biological neurons, become integrated with existing biological neural networks towards the aim of intelligence amplification and augmentation while assuming functional and experiential continuity with our existing biological nervous system) appears to be novel, while the notion of artificial ion-channels and neuronal membrane systems ion general had already been conceived (and successfully created/experimentally-verified, though presumably not integrated in-vivo).
The field of Functionally-Restorative Medicine (and the orphan sub-field of whole-brain-gradual-substrate-replacement, or “physically-embodied” brain-emulation if you like) can take advantage of the decades of experimental progress in this field, incorporating both the technological and methodological infrastructures used in and underlying the field of Ion-Channel Reconstitution and Synthetic/Artificial Ion Channels & Membrane-Systems (and the technologies and methodologies underlying their corresponding experimental-verification and incorporation techniques) for the purpose of indefinite functional restoration via the gradual and iterative replacement of neuronal components (including sections of bilipid membrane, ion channels and ion pumps) by MEMS (micro-electrocal-mechanical-systems) or more likely NEMS (nano-electro-mechanical systems).
The technological and methodological infrastructure underlying this field can be utilized for both the creation of artificial neurons and for the artificial synthesis of normative biological neurons. Much work in the field required artificially synthesizing cellular components (e.g. bilipid membranes) with structural and functional properties as similar to normative biological cells as possible, so that the alternative designs (i.e. dissimilar to the normal structural and functional modalities of biological cells or cellular components) and how they affect and elucidate cellular properties, could be effectively tested. The iterative replacement of either single neurons, or the sectional replacement of neurons with synthesized cellular components (including sections of the bi-lipid membrane, voltage-dependent ion-channels, ligand-dependent ion channels, ion pumps, etc.) is made possible by the large body of work already done in the field. Consequently the technological, methodological and experimental infrastructures developed for the fields of Synthetic
Ion-Channels and Ion-Channel/Artificial-Membrane-Reconstitution can be utilized for the purpose of a.) iterative replacement and cellular upkeep via biological analogues (or not differing significantly in structure or functional & operational modality to their normal biological counterparts) and/or b.) iterative replacement with non-biological analogues of alternate structural and/or functional modalities.
Rather than sensing when a given component degrades and then replacing it with an artificially-synthesized biological or non-biological analogue, it appears to be much more efficient to determine the projected time it takes for a given component to degrade or otherwise lose functionality, and simply automate the iterative replacement in this fashion, without providing in-vivo systems for detecting molecular or structural degradation. This would allow us to achieve both experimental and pragmatic success in such cellular-prosthesis sooner, because it doesn’t rely on the complex technological and methodological infrastructure underlying in-vivo sensing, especially on the scale of single neuron components like ion-channels, and without causing operational or functional distortion to the components being sensed.
A survey of progress in the field [3] lists several broad design motifs. I will first list the deign motifs falling within the scope of the survey, and the examples it provides. Selections from both papers are meant to show the depth and breadth of the field, rather than to elucidate the specific chemical or kinetic operations under the purview of each design-variety.
For a much more comprehensive, interactive bibliography of papers falling within the field of Synthetic Ion-Channels or constituting the historical foundations of the field, see Jon Chui’s online biography here, which charts the developments in this field up until 2011.
First Survey
Unimolecular ion channels:
Examples include a.) synthetic ion channels with oligocrown ionophores, [5] b.) using a-helical peptide scaffolds and rigid push–pull p-octiphenyl scaffolds for the recognition of polarized membranes, [6] and c.) modified varieties of the b-helical scaffold of gramicidin A [7]
Barrel-stave supramolecules:
Examples of this general class falling include avoltage-gated synthetic ion channels formed by macrocyclic bolaamphiphiles and rigidrod p-octiphenyl polyols [8].
Macrocyclic, branched and linear non-peptide bolaamphiphiles as staves:
Examples of this sub-class include synthetic ion channels formed by a.) macrocyclic, branched and linear bolaamphiphiles and dimeric steroids, [9] and by b.) non-peptide macrocycles, acyclic analogs and peptide macrocycles [respectively] containing abiotic amino acids [10].
Dimeric steroid staves:
Examples of this sub-class include channels using polydroxylated norcholentriol dimer [11].
pOligophenyls as staves in rigid rod b barrels:
Examples of this sub-class include “cylindrical self-assembly of rigid-rod b-barrel pores preorganized by the nonplanarity of p-octiphenyl staves in octapeptide-p-octiphenyl monomers” [12].
Synthetic Polymers:
Examples of this sub-class include synthetic ion channels and pores comprised of a.) polyalanine, b.) polyisocyanates, c.) polyacrylates, [13] formed by i.) ionophoric, ii.) ‘smart’ and iii.) cationic polymers [14]; d.) surface-attached poly(vinyl-n-alkylpyridinium) [15]; e.) cationic oligo-polymers [16] and f.) poly(m-phenylene ethylenes) [17].
Helical b-peptides (used as staves in barrel-stave method):
Examples of this class include: a.) cationic b-peptides with antibiotic activity, presumably acting as amphiphilic helices that form micellar pores in anionic bilayer membranes [18].
Monomeric steroids:
Examples of this sub-class falling include synthetic carriers, channels and pores formed by monomeric steroids [19], synthetic cationic steroid antibiotics [that] may act by forming micellar pores in anionic membranes [20], neutral steroids as anion carriers [21] and supramolecular ion channels [22].
Complex minimalist systems:
Examples of this sub-class falling within the scope of this survey include ‘minimalist’ amphiphiles as synthetic ion channels and pores [23], membrane-active ‘smart’ double-chain amphiphiles, expected to form ‘micellar pores’ or self-assemble into ion channels in response to acid or light [24], and double-chain amphiphiles that may form ‘micellar pores’ at the boundary between photopolymerized and host bilayer domains and representative peptide conjugates that may self assemble into supramolecular pores or exhibit antibiotic activity [25].
Non-peptide macrocycles as hoops:
Examples of this sub-class falling within the scope of this survey include synthetic ion channels formed by non-peptide macrocycles acyclic analogs [26] and peptide macrocycles containing abiotic amino acids [27].
Peptide macrocycles as hoops and staves:
Examples of this sub-class include a.) synthetic ion channels formed by self-assembly of macrocyclic peptides into genuine barrel-hoop motifs that mimic the b-helix of gramicidin A with cyclic b-sheets. The macrocycles are designed to bind on top of channels and cationic antibiotics (and several analogs) are proposed to form micellar pores in anionic membranes [28]; b.) synthetic carriers, antibiotics (and analogs) and pores (and analogs) formed by macrocyclic peptides with non-natural subunits. [Certain] macrocycles may act as b-sheets, possibly as staves of b-barrel-like pores [29]; c.) bioengineered pores as sensors. Covalent capturing and fragmentations [have been] observed on the single-molecule level within engineered a-hemolysin pore containing an internal reactive thiol [30].
Summary
Thus even without knowledge of supramolecular or organic chemistry, one can see that a variety of alternate approaches to the creation of synthetic ion channels, and several sub-approaches within each larger ‘design motif’ or broad-approach, not only exist but have been experimentally verified, varietized and refined.
Second Survey
The following selections [31] illustrate the chemical, structural and functional varieties of synthetic ions categorized according to whether they are cation-conducting or anion-conducting, respectively. These examples are used to further emphasize the extent of the field, and the number of alternative approaches to synthetic ion-channel design, implementation, integration and experimental-verification already existent. Permission to use all the following selections and figures were obtained from the author of the source.
There are 6 classical design-motifs for synthetic ion-channels, categorized by structure, that are identified within the paper:
“The first non-peptidic artificial ion channel was reported by Kobuke et al. in 1992” [33].
“The channel contained “an amphiphilic ion pair consisting of oligoether-carboxylates and mono- (or di-) octadecylammoniumcations. The carboxylates formed the channel core and the cations formed the hydrophobic outer wall, which was embedded in the bilipid membrane with a channel length of about 24 to 30 Å. The resultant ion channel, formed from molecular self-assembly, is cation selective and voltage-dependent” [34].
“Later, Kokube et al. synthesized another channel comprising of resorcinol based cyclic tetramer as the building block. The resorcin-[4]-arenemonomer consisted of four long alkyl chains which aggregated to forma dimeric supramolecular structure resembling that of Gramicidin A” [35]. “Gokel et al. had studied [a set of] simple yet fully functional ion channels known as “hydraphiles” [39].
“An example (channel 3) is shown in Figure 1.6, consisting of diaza-18-crown-6 crown ether groups and alkyl chain as side arms and spacers. Channel 3 is capable of transporting protons across the bilayer membrane” [40].
“A covalently bonded macrotetracycle4 (Figure 1.8) had shown to be about three times more active than Gokel’s ‘hydraphile’ channel, and its amide-containing analogue also showed enhanced activity” [44].
“Inorganic derivative using crown ethers have also been synthesized. Hall et. al synthesized an ion channel consisting of a ferrocene and 4 diaza-18-crown-6 linked by 2 dodecyl chains (Figure 1.9). The ion channel was redox-active as oxidation of the ferrocene caused the compound to switch to an inactive form” [45]
B STAVES:
“These are more difficult to synthesize [in comparison to unimolecular varieties] because the channel formation usually involves self-assembly via non-covalent interactions” [47].“A cyclic peptide composed of even number of alternating D- and L-amino acids (Figure 1.10) was suggested to form barrel-hoop structure through backbone-backbone hydrogen bonds by De Santis” [49].
“A tubular nanotube synthesized by Ghadiri et al. consisting of cyclic D and L peptide subunits form a flat, ring-shaped conformation that stack through an extensive anti-parallel β-sheet-like hydrogen bonding interaction (Figure 1.11)” [51].
“Experimental results have shown that the channel can transport sodium and potassium ions. The channel can also be constructed by the use of direct covalent bonding between the sheets so as to increase the thermodynamic and kinetic stability” [52].
“By attaching peptides to the octiphenyl scaffold, a β-barrel can be formed via self-assembly through the formation of β-sheet structures between the peptide chains (Figure 1.13)” [53].
“The same scaffold was used by Matile etal. to mimic the structure of macrolide antibiotic amphotericin B. The channel synthesized was shown to transport cations across the membrane” [54].
“Attaching the electron-poor naphthalenediimide (NDIs) to the same octiphenyl scaffold led to the hoop-stave mismatch during self-assembly that results in a twisted and closed channel conformation (Figure 1.14). Adding the compleentary dialkoxynaphthalene (DAN) donor led to the cooperative interactions between NDI and DAN that favors the formation of barrel-stave ion channel.” [57].
MICELLAR
“These aggregate channels are formed by amphotericin involving both sterols and antibiotics arranged in two half-channel sections within the membrane” [58].
“An active form of the compound is the bolaamphiphiles (two-headed amphiphiles). (Figure 1.15) shows an example that forms an active channel structure through dimerization or trimerization within the bilayer membrane. Electrochemical studies had shown that the monomer is inactive and the active form involves dimer or larger aggregates” [60].
ANION CONDUCTING CHANNELS:
“A highly active, anion selective, monomeric cyclodextrin-based ion channel was designed by Madhavan et al (Figure 1.16). Oligoether chains were attached to the primary face of the β-cyclodextrin head group via amide bonds. The hydrophobic oligoether chains were chosen because they are long enough to span the entire lipid bilayer. The channel was able to select “anions over cations” and “discriminate among halide anions in the order I-> Br-> Cl- (following Hofmeister series)” [61].
“The anion selectivity occurred via the ring of ammonium cations being positioned just beside the cyclodextrin head group, which helped to facilitate anion selectivity. Iodide ions were transported the fastest because the activation barrier to enter the hydrophobic channel core is lower for I- compared to either Br- or Cl-“ [62]. “A more specific artificial anion selective ion channel was the chloride selective ion channel synthesized by Gokel. The building block involved a heptapeptide with Proline incorporated (Figure 1.17)” [63].
Cellular Prosthesis: Inklings of a New Interdisciplinary Approach
The paper cites “nanoreactors for catalysis and chemical or biological sensors” and “interdisciplinary uses as nano –filtration membrane, drug or gene delivery vehicles/transporters as well as channel-based antibiotics that may kill bacterial cells preferentially over mammalian cells” as some of the main applications of synthetic ion-channels [65], other than their normative use in elucidating cellular function and operation.
However, I argue that a whole interdisciplinary field and heretofore-unrecognized new approach or sub-field of Functionally-Restorative Medicine is possible through taking the technologies and techniques involved in in constructing, integrating, and experimentally-verifying either a.) non-biological analogues of ion-channels & ion-pumps (thus trans-membrane membrane proteins in general, also sometimes referred to as transport proteins or integral membrane proteins) and membranes (which include normative bilipid membranes, non-lipid membranes and chemically-augmented bilipid membranes), and b.) the artificial synthesis of biological analogues of ion-channels, ion-pumps and membranes, which are structurally and chemically equivalent to naturally-occurring biological components but which are synthesized artificially – and applying such technologies and techniques toward the purpose the gradual replacement of our existing biological neurons constituting our nervous systems – or at least those neuron-populations that comprise the neo- and prefrontal-cortex, and through iterative procedures of gradual replacement thereby achieving indefinite-longevity. There is still work to be done in determining the comparative advantages and disadvantages of various structural and functional (i.e. design) motifs, and in the logistics of implanting the iterative replacement or reconstitution of ion-channels, ion-pumps and sections of neuronal membrane in-vivo.
The conceptual schemes outlined in Concepts for Functional Replication of Biological Neurons [66], Gradual Neuron Replacement for the Preservation of Subjective-Continuity [67] and Wireless Synapses, Artificial Plasticity, and Neuromodulation [68] would constitute variations on the basic approach underlying this proposed, embryonic interdisciplinary field. Certain approaches within the fields of nanomedicine itself, particularly those approaches that constitute the functional emulation of existing cell-types, such as but not limited to Robert Freitas’s conceptual designs for the functional emulation of the red blood cell (a.k.a. erythrocytes, haematids) [69], i.e. the Resperocyte, itself should be seen as falling under the purview of this new approach, although not all approaches to Nanomedicine (diagnostics, drug-delivery and neuroelectronic interfacing) constitute the physical (i.e. electromechanical, kinetic and/or molecular physically-embodied) and functional emulation of biological cells.
The field of functionally-restorative medicine in general (and of nanomedicine in particular) and the field of supramolecular and organic chemistry converge here, where these technological, methodological, and experimental infrastructures developed in field of Synthetic Ion-Channels and Ion Channel Reconstitution can be employed to develop a new interdisciplinary approach that applies the logic of prosthesis to the cellular and cellular-component (i.e. sub-cellular) scale; same tools, new use. These techniques could be used to iteratively replace the components of our neurons as they degrade, or to replace them with more robust systems that are less susceptible to molecular degradation. Instead of repairing the cellular DNA, RNA and protein transcription and synthesis machinery, we bypass it completely by configuring and integrating the neuronal components (ion-channels, ion-pumps and sections of bilipid membrane) directly.
Thus I suggest that theoreticians of nanomedicine look to the large quantity of literature already developed in the emerging fields of synthetic ion-channels and membrane-reconstitution, towards the objective of adapting and applying existing technologies and methodologies to the new purpose of iterative maintenance, upkeep and/or replacement of cellular (and particularly neuronal) constituents with either non-biological analogues or artificially-synthesized-but-chemically/structurally-equivalent biological analogues.
This new sub-field of Synthetic Biology needs a name to differentiate it from the other approaches to Functionally-Restorative Medicine. I suggest the designation ‘cellular prosthesis’.
References:
[1] Williams (1994)., An introduction to the methods available for ion channel reconstitution. in D.C Ogden Microelectrode techniques, The Plymouth workshop edition, CambridgeCompany of Biologists.
[2] Tomich, J., Montal, M. (1996). U.S Patent No. 5,16,890. Washington, DC: U.S. Patent and Trademark Office.
[69] Freitas Jr., R., (1998). “Exploratory Design in Medical Nanotechnology: A Mechanical Artificial Red Cell”. Artificial Cells, Blood Substitutes, and Immobil. Biotech. (26): 411–430. Access: http://www.ncbi.nlm.nih.gov/pubmed/9663339
I continue to survey the available technology applicable to spaceflight and there is little change.
The remarkable near impact and NEO on the same day seems to fly in the face of the experts quoting a probability of such coincidence being low on the scale of millenium. A recent exchange on a blog has given me the idea that perhaps crude is better. A much faster approach to a nuclear propelled spaceship might be more appropriate.
Unknown to the public there is such a thing as unobtanium. It carries the country name of my birth; Americium.
A certain form of Americium is ideal for a type of nuclear solid fuel rocket. Called a Fission Fragment Rocket, it is straight out of a 1950’s movie with massive thrust at the limit of human G-tolerance. Such a rocket produces large amounts of irradiated material and cannot be fired inside, near, or at the Earth’s magnetic field. The Moon is the place to assemble, test, and launch any nuclear mission.
Such Fission Fragment propelled spacecraft would resemble the original Tsolkovsky space train with a several hundred foot long slender skeleton mounting these one shot Americium boosters. The turn of the century deaf school master continues to predict.
Each lamp-shade-spherical thruster has a programmed design balancing the length and thrust of the burn. After being expended the boosters use a small secondary system to send them into an appropriate direction and probably equipped with small sensor packages, using the hot irradiated shell for an RTG. The Frame that served as a car of the space train transforms into a pair of satellite panels. Being more an artist than an *engineer, I find the monoplane configuration pleasing to the eye as well as being functional. These dozens and eventually thousands of dual purpose boosters would help form a space warning net.
The front of the space train is a large plastic sphere partially filled filled with water sent up from the surface of a a Robotic Lunar Polar Base. The Spaceship would split apart on a tether to generate artificial gravity with the lessening booster mass balanced by varying lengths of tether with an intermediate reactor mass.
These piloted impact threat interceptors would be manned by the United Nations Space Defense Force. All the Nuclear Powers would be represented.…..well, most of them. They would be capable of “fast missions” lasting only a month or at the most two months. They would be launched from underground silos on the Moon to deliver a nuclear weapon package towards an impact threat at the highest possible velocity and so the fastest intercept time. These ships would come back on a ballistic course with all their boosters expended to be rescued by recovery craft from the Moon upon return to the vicinity of Earth.
The key to this scenario is Americium 242. It is extremely expensive stuff. The only alternative is Nuclear Pulse Propulsion (NPP). The problem with bomb propulsion is the need to have a humungous mass for the most efficient size of bomb to react with.
The Logic Tree then splits again with two designs of bomb propelled ship; the “Orion” and the “Medusa.” The Orion is the original design using a metal plate and shock absorbing system. The Medusa is essentially a giant woven alloy parachute and tether system that replaces the plate with a much lighter “mega-sail.” In one of the few cases where compromise might bear fruit- the huge spinning ufo type disc, thousands of feet across, would serve quite well to explore, colonize, and intercept impact threats. Such a ship would require a couple decades to begin manufacture on the Moon.
Americium boosters could be built on earth and inserted into lunar orbit with Human Rated Heavy Lift Vehicles (SLS) and a mission launched well within a ten-year apollo type plan. But the Americium Infrastructure has to be available as a first step.
Would any of my hundreds of faithful followers be willing to assist me in circulating a petition?
*Actually I am neither an artist or an engineer- just a wannabe pulp writer in the mold of Edgar Rice Burroughs.
Recently, I met Josh Hopkins of Lockheed’s Advanced Programs, AIAA Rocky Mountain Region’s First Annual Technical Symposium (RMATS), October 26, 2012. Josh was the keynote speaker at this RMATS. Here is his presentation. After his presentation we talked outside the conference hall. I told him about my book, and was surprised when he said that two groups had failed to reproduce Podkletnov’s work. I knew one group had but a second? As we parted we said we’d keep in touch. But you know how life is, it has the habit of getting in the way of exciting research, and we lost touch.
About two weeks ago, I remembered, that Josh had said that he would provide some information on the second group that had failed to reproduce Podkletnov’s work. I sent him an email, and was very pleased to hear back from him and that the group’s finding had been published under the title “Gravity Modification by High-Temperature Semiconductors”. The authors were C. Woods, S. Cooke, J. Helme & C. Caldwell. Their paper was published in the 37th AIAA/ASME/SAE/ASEE Joint Propulsion Conference and Exhibit, 8–11 July 2001, Salt Lake City, Utah. I bought a copy for the AIAA archives, and read it, reread it, and reread it.
Then I found a third team they published their lack of findings “Gravity Modification Experiments Using a Rotating Superconducting Disk and Radio Frequency Fields”. The authors were G. Hathaway, B. Cleveland and Y. Bao. Published in Physica C, 2003.
Both papers focused on attempting to build a correct superconducting disc. At least Wood et al said “the tests have not fulfilled the specified conditions for a gravity effect”. The single most difficult thing to do was to build a bilayered superconducting disc. Woods et al tried very hard to do so. Reading through Hathaway et all paper suggest that they too had similar difficulties. Photo shows a sample disc from Woods’ team. Observe the crack in the middle.
Further, Woods’ team was able to rotate their disc to 5,000 rpm. Hathaway’s team reports a rotational speed of between 400–800 rpm, a far cry from Podkletnov’s 5,000 rpm. This suggests that there were other problems in Hathaway’s disc not reported in their paper. With 400–800 rpm, if Hathaway were to observe a significant weight change it would have been less than the repeatable experimental sensitivity of 0.5mg!
Here are some quotes from Hathaway et al’s original paper “As a result of these tests it was decided that either the coil designs were inefficient at producing …”, “the rapid induction heating at room temperature cracked the non-superconducting disk into two pieces within 3 s”, “Further tests are needed to determine the proper test set-up required to detect the reverse Josephson junction effect in multi-grain bulk YBCO superconductors”.
It is quite obvious from reading both papers that neither team were able to faithfully reproduce Podkletnov’s work, and it is no wonder that at least Woods et al team stated “the tests have not fulfilled the specified conditions for a gravity effect”. This statement definitely applies to Hathaway et al’s research. There is more to critic both investigations, but .… this should be enough.
Now, for the final surprise. The first team I had mentioned earlier. Ning Li led the first team comprised of members from NASA and University of Huntsville, AL. It was revealed in conversations with a former team member that Ning Li’s team was disbanded before they could build the superconducting discs required to investigate Podkletnov’s claims. Wow!
If you think about it, all these “investigations” just showed that nobody in the US was capable of faithfully reproducing Podkletnov’s experiments to even disprove it.
What a big surprise! A null result is not a disproof.
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Benjamin T Solomon is the author & principal investigator of the 12-year study into the theoretical & technological feasibility of gravitation modification, titled An Introduction to Gravity Modification, to achieve interstellar travel in our lifetimes. For more information visit iSETI LLC, Interstellar Space Exploration Technology Initiative.
Using an innocuous bacterial virus, bioengineers have created a biological mechanism to send genetic messages from cell to cell. The system greatly increases the complexity and amount of data that can be communicated between cells and could lead to greater control of biological functions within cell communities…
In harnessing DNA for cell-cell messaging the researchers have also greatly increased the amount of data they can transmit at any one time. In digital terms, they have increased the bit rate of their system. The largest DNA strand M13 is known to have packaged includes more than 40,000 base pairs. Base pairs, like 1s and 0s in digital encoding, are the basic building blocks of genetic data. Most genetic messages of interest in bioengineering range from several hundred to many thousand base pairs.
Ortiz was even able to broadcast her genetic messages between cells separated by a gelatinous medium at a distance of greater than 7 centimeters.
“That’s very long-range communication, cellularly speaking,” she said.
Down the road, the biological Internet could lead to biosynthetic factories in which huge masses of microbes collaborate to make more complicated fuels, pharmaceuticals and other useful chemicals. With improvements, the engineers say, their cell-cell communication platform might someday allow more complex three-dimensional programming of cellular systems, including the regeneration of tissue or organs. Continue reading “Stanford Bioengineers Introduce ‘Bi-Fi’ — The Biological Internet”
I have been meaning to read a book coming out soon called Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves. It’s written by Harvard biologist George Church and science writer Ed Regis. Church is doing stunning work on a number of fronts, from creating synthetic microbes to sequencing human genomes, so I definitely am interested in what he has to say. I don’t know how many other people will be, so I have no idea how well the book will do. But in a tour de force of biochemical publishing, he has created 70 billion copies. Instead of paper and ink, or pdf’s and pixels, he’s used DNA.
Much as pdf’s are built on a digital system of 1s and 0s, DNA is a string of nucleotides, which can be one of four different types. Church and his colleagues turned his whole book–including illustrations–into a 5.27 MB file–which they then translated into a sequence of DNA. They stored the DNA on a chip and then sequenced it to read the text. The book is broken up into little chunks of DNA, each of which has a portion of the book itself as well as an address to indicate where it should go. They recovered the book with only 10 wrong bits out of 5.27 million. Using standard DNA-copying methods, they duplicated the DNA into 70 billion copies.
Scientists have stored little pieces of information in DNA before, but Church’s book is about 1,000 times bigger. I doubt anyone would buy a DNA edition of Regenesis on Amazon, since they’d need some expensive equipment and a lot of time to translate it into a format our brains can comprehend. But the costs are crashing, and DNA is a far more stable medium than that hard drive on your desk that you’re waiting to die. In fact, Regenesis could endure for centuries in its genetic form. Perhaps librarians of the future will need to get a degree in biology…
It is a race against time- will this knowledge save us or destroy us? Genetic modification may eventually reverse aging and bring about a new age but it is more likely the end of the world is coming.
The Fermi Paradox informs us that intelligent life may not be intelligent enough to keep from destroying itself. Nothing will destroy us faster or more certainly than an engineered pathogen (except possibly an asteroid or comet impact). The only answer to this threat is an off world survival colony. Ceres would be perfect.
“The more anxiety one produces, the more the discussion there would be about how real and how possible actual existential threats are.”
John Hunt recently queried me on what steps I might take to form an organization to advocate for survival colonies and planetary defense. His comment on anxiety is quite succinct. In truth the landing on the moon was the product of fear- of the former Soviet Union’s lead in rocket technology. As we as a nation quelled that anxiety the budget for human space flight dwindled. But the fear of a nuclear winter continued to grow along with the size of our arsenals.
Interestingly, at the height of the cold war, evidence of yet another threat to human existence was uncovered in the Yucatan peninsula of Mexico in 1981; Chicxulub. But even before the dinosaur killer was discovered, perhaps the greatest threat of all to humanity was born in 1973 when Herb Boyer and Stanley Cohen created the first genetically modified organism. The money to answer both of these threats by going into space continues to be expended by the military industrial complex.
Mile wide rocks in space and microscopic organisms on earth are both threats to our existence, but the third and undoubtedly greatest threat is our own apathy. Why do we expend the tremendous resources of our race on everything BUT keeping it from going extinct?
The answer to this important question is our own fear of death. As I have written previously, we are as individuals in the predicament of a circus freak on death row. It is a bizarre yet accurate characterization. None of us expect to live forever, but then we do not expect to die tomorrow either. We are in limbo between certain death and temporary life and cannot face the reality of the first while obsessing over the banalities of the second.
Examples of our determination to stay distracted can be found in the babbling of gravity modifiers, CERN doomsday prophets, and various other fruit flavored contributors to this blog. We desperately want to believe in UFO’s, conspiracies and fantastical solutions so we do not have to face the disquiet we experience whenever we pass a funeral home or graveyard. I am happy to pummel these idiots with the harsh language they deserve- especially when they destroy the credibility of sites like this which are trying to accomplish something worthwhile.
So I am thinking there is so much anxiety being monopolized that there is little market left for me capitalize on. Something different is required; as Bill Gates advised young entrepreneurs recently, “Don’t do what I did.” It has all been done and no clever marketing or deceptive advertising is going to build cities on other worlds. Space tourism is not going to save us- if anything it is a dangerous waste of time and money.
What is required is a popular culture renaissance that can focus the energy of several generations in a single direction. The uniqueness of this crossroads in history can be found in considering the nearly unbelievable difference in the level of scientific knowledge today compared to a half century ago. There is nothing more evident to the mature members of the western world than it’s age- our standard of living has brought about fewer children while the less fortunate parts of the world have accelerated their reproductive rates. Disparities in wealth and standards of living are stark evidence of the circus freak scenario. Very few of us are aware that there is a possible escape from this death sentence we are all born under. A standby of science fiction for decades has been the freezing of human beings for space travel. To delay death indefinitely and be resurrected when a cure for a disease or old age is found is a familiar concept. The parallels with Christianity are unmistakable.
We, as in my fellow human beings who were born around 1960, are seeing the culture we grew up in fade away as no other generation ever has. We lived through decades of threatened nuclear holocaust only to see our hoped for space age future dismantled by consumerism and profiteering. Personally, I find the presence of skulls everywhere to be the most poignant and disturbing portent of things to come. The veterans who fought in World War II and were everywhere when I was a boy would never have allowed this emblem of the Nazi SS to become so popular. It was the symbol of ruthless and murderous force as being the only meaningful feature of reality. 60 million human beings were killed in the fight against the evil it represents. And now it is back.
To counter to the present lack of vision I would like to introduce an agent of change in the form of a idealized past age. What better ideal than the movement that conquered fascism originally? Christianity did in fact conquer the Roman Empire- and as it is said we are all children of Rome, then we are also children of the carpenter from Nazareth. A technological analogy that can be discerned when considering the original Christianity and the modern world is the Gladius and the Atom Bomb. The Romans learned the fine points of using their infamous short swords by watching gladiators fight to the death- a funerary tradition they inherited from the Etruscans they assimilated. The training of professional gladiators was applied to the military and made “Drill a bloodless Battle and Battle a bloody Drill.”
The sword made the Roman Empire and Christianity inherited this prize. The Atom Bomb has kept modern civilization from World War for over a half century- but so far there is no great social movement that will inherit this mighty construct before it falls into a new dark age. The Fermi Paradox points to the possibility that this empire could well be the last; there will be no more cycles of civilizations rising and falling if we become extinct. If so then this really may be the end of the world- with no need to throw away reason in favor of the Book of Revelation.
What is most curious is that while the sword had no utility outside of murder, the Atomic Bomb holds the power to transcend this arena of earth and allow humankind to populate the galaxy. If this civilization can survive to travel to new worlds then the last empire will have risen- the last because it can never fall again.
So, to form a society of believers in life, in the future of the human race, the goals must be clear and easily understood;
If the human race is to survive, the individual must have some hope of surviving. The immediate need is a way to delay death and that procedure is practically a reality with advances in cryopreservation.
If the human race is to survive, new worlds must be found and colonized. The immediate need is for survival colonies off-world and atomic spaceships to establish those colonies and defend the earth from impact threats.
If the individual and the race as a whole is to survive, action must be taken. The immediate need is an organization to take money in and distribute it to the corporations and politicians that can direct the massive governmental resources necessary to accomplish a great rescue with cryopreservation and to construct spaceships to establish off world colonies and deflect impact threats.
Figuratively, metaphorically, the Christians conquered the old empire and the Astronomers who harness the power of the sun will inherit this empire. Since the more catchy titles have been taken by religious cults, I suggest the organization that will initiate action be called,
The Society of Christian Astronomers
My first call is for the money to copyright the title of the society and a brand I have in mind.
I have been corresponding with John Hunt and have decided that perhaps it is time to start moving toward forming a group that can accomplish something.
The recent death of Neil Armstrong has people thinking about space. The explosion of a meteor over Britain and the curiosity rover on Mars are also in the news. But there is really nothing new under the sun. There is nothing that will hold people’s attention for very long outside of their own immediate comfort and basic needs. Money is the central idea of our civilization and everything else is soon forgotten. But this idea of money as the center of all activity is a death sentence. Human beings die and species eventually become extinct just as worlds and suns also are destroyed or burn out. Each of us is in the position of a circus freak on death row. Bizarre, self centered, doomed; a cosmic joke. Of all the creatures on this planet, we are the freaks the other creatures would come to mock- if they were like us. If they were supposedly intelligent like us. But are we actually the intelligent ones? The argument can be made that we lack a necessary characteristic to be considered truly intelligent life forms.
Truly intelligent creatures would be struggling with three problems if they found themselves in our situation as human beings on Earth in the first decades of this 21st century;
1. Mortality. With technology possible to delay death and eventually reverse the aging process, intelligent beings would be directing the balance of planetary resources towards conquering “natural” death.
2. Threats. With technology not just possible, but available, to defend the earth from extinction level events, the resources not being used to seek an answer to the first problem would necessarily be directed toward this second danger.
3. Progress. With science advancing and accelerating, the future prospects for engineering humans for greater intelligence and eventually building super intelligent machines are clear. Crystal clear. Not addressing these prospects is a clear warning that we are, as individuals, as a species, and as a living planet, headed not toward a bright future, but in the opposite direction toward a dead and final end.
One engineered pathogen will destroy us forever. One impact larger than average will destroy us forever. The reasoning that death is somehow “natural” which drives us to ignore the subject of destruction will destroy us forever. Earth changes are inevitable and taking place now- despite our faith in television and popular culture that everything is fun and games. Man is not the measure of all things. We think tomorrow will come just like yesterday- but it will not.
The Truth about Space Travel is that there are no stargates or warp drives that will take us across the galaxy like commecial airliners or cruise ships take us across oceans. If we do wake up and change our course, space voyages will take centuries and human expansion will be measured in millenia. We will be frozen when we travel to distant stars. And this survivable freezing will mark the beginning of a new age since being able to delay death by freezing will completely transform life. The first such successful procedure will mean the end of the world as we know it- and the beginning of a new civilization.
Though unknown to the public, the atomic bomb and then the hydrogen bomb marked the true beginning of the Space Age. Hydrogen bombs can push cities in space, hollow moons, to some percentage of the speed of light. These cities can travel to other stars, such as Epsilon Eridani with it’s massive asteroid belt. And there more artificial hollow moons can be mass produced to provide new worlds to live in. This is not fiction I am speaking of but something we could do right now- today. We only lack the procedure to freeze and successfully revive a human being. It is, indeed, stranger than fiction.
In Beam Propulsion we have the answer to bending the rocket equation to our will and allowing millions and eventually billions of human beings to migrate into space. Just as Verne and Wells made accurate predictions of the decades to come, we now are seeing the possible obvious future unfolding before our eyes.
But the most possible and probable obvious future at this moment is destruction. The end of days. Unless we do something. You and I and everyone you know is involved in this. Let’s get started.
