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Category: chemistry – Page 381

Our friends at the Methuselah Foundation are working on macular degeneration.

Typically, a fellowship and participation in a research study to cure a major disease would occur years after completing undergrad, possibly even after earning a PhD. But Jennifer DeRosa is not a typical student.

As early as high school, DeRosa was already in the lab, conducting research in plant biotechnology at the College of Environmental Science and Forestry (SUNY-ESF) before graduating valedictorian from Skaneateles High School. As a freshman student at Onondaga Community College, she continued to develop skills in molecular biology, analytical chemistry, and cell biology. She logged over 1,600 hours in academic and industry laboratories while maintaining a perfect 4.0 GPA, completing her associate’s degree in Math and Science in only one year.

Although she had planned to continue to a bachelor’s program, DeRosa elected to defer enrollment after being offered a Methuselah Foundation research fellowship. “The fellowship provides distinguished students a year-long stipend to work in any laboratory of their choosing that conducts work on age-associated diseases,” said Methuselah Foundation CEO David Gobel. “We are very pleased that she chose to complete her fellowship at Ichor Therapeutics, where she has been working as a paid intern. Methuselah Foundation has a high degree of confidence in the quality and scope of work being conducted there.”

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Watching DNA self-repair itself.

After 2015’s Nobel Prize in chemistry was awarded for advancements in our understanding of DNA repair, a recent Nature report characterises the mechanism in molecular detail. The implications for cancer research are vast.

Researchers in Paris, France, and Bristol, England, have leveraged recent advances in microscopy and fluorescent imaging to characterise the entire process of DNA repair at the molecular level. They were able to observe RNA polymerase, which ‘reads’ DNA and initiates its replication, as it moved along the DNA strand.

When it encountered damage inflicted by UV radiation, the enzyme stalled, and a number of proteins descended on the site. The team followed them as they acted in an ordered step-wise fashion and elucidated the critical steps of the DNA repair process: first, a protein called Mfd coordinates to RNA polymerase, then it directs a sort of relay team of UvrA, UvrB and UvrC. This deeper understanding of the mechanism could bolster efforts towards treatments for a variety of conditions.

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Scientists have developed self-propelling liquid metals that could be used for future electronic circuits.

Current electronic technology is based on solid state components with fixed metallic tracks and semiconductors. Researchers are investigating soft circuit systems that act like live cells, communicating with each other to form new circuits when possible. In one study, Professor Kalantar-zadeh from RMIT University in Australia, along with his researchers immersed a number of different metallic elements, in the form of liquid droplets, in water.

Professor Kourosh Kalantar-zadeh said: “Putting droplets in another liquid with an ionic content can be used for breaking symmetry across them and allow them to move about freely in three dimensions. We adjusted the concentrations of acid, base and salt components in the water and investigated the effect. Simply tweaking the water’s chemistry made the liquid metal droplets move and change shape, without any need for external mechanical, electronic or optical stimulants.”

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I never get tired of talking about the many uses for Q-dot technology. One area that has me even more intrigued is how it is used in crystallized formations. I expect to see more and more experimenting on crystalized formations on many fronts including complex circuitry for performance and storage.

And, with synthetic technology today plus 3D printing along with Q-dots we could (as I have eluded to many times over several months) truly begin to see some amazing technology be developed on the wearable tech front.

Wearables could include synthetic circuitry stones in various accessories to not only store information, but also serve as another form of unique id because in synthetic stones we have been able (like in nature) create complex crystalized formations that are each unique/ 1 of a kind like a unique finger print, or iris of an eye. I expect to see some very interesting things coming in this space.

Unique optical features of quantum dots make them an attractive tool for many applications, from cutting-edge displays to medical imaging. Physical, chemical or biological properties of quantum dots must, however, be adapted to the desired needs.

Unfortunately, up to now quantum dots prepared by chemical methods could only be functionalized using copper-based click reactions with retention of their luminescence. This obstacle can be ascribed to the fact that copper ions destroy the ability of quantum dots to emit light. Scientists from the Institute of Physical Chemistry of the Polish Academy of Sciences (IPC PAS) in Warsaw and the Faculty of Chemistry of the Warsaw University of Technology (FC WUT) have shown, however, that zinc oxide (ZnO) quantum dots prepared by an original method developed by them, after modification by the click reaction with the participation of copper ions, fully retain their ability to emit light.

“Click reactions catalyzed by copper cations have long attracted the attention of chemists dealing with quantum dots. The experimental results, however, were disappointing: after modification, the luminescence was so poor that they were just not fit for use. We were the first to demonstrate that it is possible to produce quantum dots from organometallic precursors in a way they do not lose their valuable optical properties after being subjected to copper-catalysed click reactions,” says Prof. Janusz Lewinski (IPC PAS, FC WUT).

Continue reading “Quantum dots with impermeable shell used as a powerful tool for “nano-engineering”” | >

According to theoretical physicist and super-genius Stephen Hawking, “The human race is just a chemical scum on a moderate-sized planet orbiting round a very average star in the outer suburb of one among a hundred billion galaxies.” Indeed, to most modern scientists we are nothing more than an entirely random ‘happy accident’ that likely would not occur if we were to rewind the tape of the universe and play it again. But what if that is completely wrong? What if life is not simply a statistical anomaly, but instead an inevitable consequence of the laws of physics and chemistry?

A new theory of the origin of life, based firmly on well-defined physics principles, provides hefty support for the notion that biological life is a “cosmic imperative”. In other words, organic life had to eventually emerge. If such a theory were true, it would mean that it is very likely that life is widespread throughout the universe.

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Synthetic biology is an emerging and rapidly evolving engineering discipline. Within the NCCR Molecular Systems Engineering, Scientists from Bernese have developed a version of the light-driven proton pump proteorhodopsin, which is chemically switchable and it is also an essential tool to efficiently power synthetic cells and molecular factories.

Synthetic biology is a highly complex field with numerous knowledge branches that incorporate physics, biology, and chemistry into engineering. It aims to design synthetic cells and molecular factories with innovative functions or properties that can be applied in medical and biological research or healthcare, industry research.

These artificial systems are available in the nanometer scale and are developed by assembling and combining current, synthetic or engineered building blocks (e.g., proteins). Molecular systems are applicable for a wide range of applications, for instance these systems can be used for waste disposal, medical treatment or diagnosis, energy supply and chemical compound synthesis.

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Magine a future in which hyper-efficient solar panels provide renewable sources of energy, improved water filters quickly remove toxins from drinking water, and the air is scrubbed clean of pollution and greenhouse gases. That could become a reality with the right molecules and materials.

Scientists from Harvard and Google have taken a major step toward making the search for those molecules easier, demonstrating for the first time that a quantum computer could be used to model the electron interactions in a complex molecule. The work is described in a new paper published in the journal Physical Review X by Professor Alán Aspuru-Guzik from the Department of Chemistry and Chemical Biology and several co-authors.

“There are a number of applications that a quantum computer would be useful for: cryptography, machine learning, and certain number-theory problems,” Aspuru-Guzik said. “But one that has always been mentioned, even from the first conceptions of a quantum computer, was to use it to simulate matter. In this case, we use it to simulate chemistry.”

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Tempus fugit. I’m just about old enough to remember a time in which 2020 was the distant future of science fiction novels, too far away to be thinking about in concrete terms, a foreign and fantastical land in which anything might happen. Several anythings did in fact happen, such as the internet, and the ongoing revolution in biotechnology that has transformed the laboratory world but leaks into clinics only all too slowly. Here we are, however, close enough to be making plans and figuring out what we expect to be doing when the third decade of the 21st century gets underway. The fantastical becomes the mundane. We don’t yet have regeneration of organs and limbs, or therapies to greatly extend life, but for these and many other staples of golden age science fiction, the scientific community has come close enough to be able to talk in detail about the roads to achieving these goals.

Of all the things that researchers might achieve with biotechnology in the near future, control over aging is by far the most important. Aging is the greatest cause of death and suffering in the world, and none of us are getting any younger. That may change, however. SENS, the Strategies for Engineered Negligible Senescence, is a synthesis of the scientific view of aging as an accumulation of specific forms of cell and tissue damage, pulling in a century of evidence from many diverse areas of medical science to support this conclusion. Aging happens because the normal operation of our cellular biochemistry produces damage, wear and tear at the level of molecules and molecular structures, and some of that damage accumulates to cause failure of tissues and organs, and ultimately death.

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We spend our lives surrounded by hi-tech materials and chemicals that make our batteries, solar cells and mobile phones work. But developing new technologies requires time-consuming, expensive and even dangerous experiments.

Luckily we now have a secret weapon that allows us to save time, money and risk by avoiding some of these experiments: computers.

Thanks to Moore’s law and a number of developments in physics, chemistry, computer science and mathematics over the past 50 years (leading to Nobel Prizes in Chemistry in 1998 and 2013) we can now carry out many experiments entirely on computers using modelling.

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