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Category: chemistry – Page 37

Investigators from Cedars-Sinai and the University of California, San Francisco (UCSF) have identified a new way to deliver instructions that tell stem cells to grow into specific bodily structures, a critical step in eventually regenerating and repairing tissues and organs.

The scientists engineered cells that form structures called “synthetic organizers.” These organizers provided instructions to the stem cells through called morphogens, which stimulated and enabled the stem cells to grow into specific complex tissues and organ-like assemblies.

The research was conducted with mouse , and the findings were published in Cell.

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If you’ve heard of two of the brain’s chemical neurotransmitters, it’s probably dopamine and serotonin. Never mind that glutamate and GABA do most of the work—it’s the thrill of dopamine as the “pleasure chemical” and serotonin as a tender mood-stabilizer that attract all the headlines.

Of course, the headlines mostly get it wrong. Dopamine’s role in shaping behavior goes way beyond simple concepts like “pleasure” or even “reward”. And the fact that it takes weeks or months for serotonin-boosting SSRI antidepressants to work suggests that it’s not actually the immediate jump in serotonin levels that drum out the doldrums of depression, but some still-mysterious shift in downstream brain circuits.

A new study from Stanford’s Wu Tsai Neurosciences Institute reveals yet another new facet of these mood-managing molecules. The research, published November 25, 2024 in Nature, demonstrates for the first time exactly how dopamine and serotonin work together—or more precisely, in opposition—to shape our behavior.

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There’s a good chance you owe your existence to the Haber-Bosch process.

This industrial chemical reaction between hydrogen and nitrogen produces , the key ingredient in synthetic fertilizers that supply much of the world’s food supply and enabled the population explosion of the last century.

It may also threaten the existence of future generations. The process consumes about 2% of the world’s total energy supply, and the hydrogen required for the reaction mostly comes from fossil fuels.

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Different types of cancer have distinct molecular “fingerprints” that can be identified in the early stages of the disease with remarkable accuracy. Small, portable scanners can detect these fingerprints within just a few hours, according to a study published today in Molecular Cell.

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona made this breakthrough, paving the way for non-invasive diagnostic tests that could identify various types of cancer more quickly and at earlier stages than current methods allow.

The study centers around the ribosome, the protein factories of a cell. For decades, ribosomes were thought to have the same blueprint across the human body. However, researchers discovered a hidden layer of complexity – tiny chemical modifications which vary between different tissues, developmental stages, and diseases.

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A team of University of Melbourne researchers from the Caruso Nanoengineering Group has created an innovative drug delivery system with outstanding potential to improve drug development.

The team has pioneered a that is a coordination network composed of only metal ions and biomolecules, known as metal–biomolecule network (MBN). This system eliminates the need for complicated drug “carriers,” making it potentially more useful in a range of applications.

The research has been published in Science Advances and was led by Melbourne Laureate Professor and NHMRC Leadership Fellow Frank Caruso, from the Department of Chemical Engineering in the Faculty of Engineering and Information Technology, with Research Fellows Dr. Wanjun Xu and Dr. Zhixing Lin joint first authors.

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Research utilizing AI tool AlphaFold has revealed a new protein complex that initiates the fertilization process between sperm and egg, shedding light on the molecular interactions essential for successful fertilization.

Genetic research has uncovered many proteins involved in the initial contact between sperm and egg. However, direct proof of how these proteins bind or form complexes to enable fertilization remained unclear. Now, Andrea Pauli’s lab at the IMP, working with international collaborators, has combined AI-driven structural predictions with experimental evidence to reveal a key fertilization complex. Their findings, based on studies in zebrafish, mice, and human cells, were published in the journal Cell.

Fertilization is the first step in forming an embryo, starting with the sperm’s journey toward the egg, guided by chemical signals. When the sperm reaches the egg, it binds to the egg’s surface through specific protein interactions. This binding readies their membranes to merge, allowing their genetic material to combine and create a zygote—a single cell that will eventually develop into a new organism.

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Researchers have used a chemical compound to light up treatment-resistant cancers on imaging scans, in a breakthrough that could help medical professionals better target and treat cancer.

The authors at King’s College London say that using the radiotracer—an injected compound used in PET scans—could help inform doctors that a patient’s aggressive cancer will not respond to chemotherapy before treatment is given. This would prevent patients receiving unnecessary treatment and provide them with alternative options that will give them the best chance of beating the disease.

The paper, “Imaging NRF2 activation in non-small cell lung cancer with ” published in Nature Communications, shows therapy-resistant tumors “lit up like a Christmas tree” on PET scans when the radiotracer was injected.

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Researchers at MIT are developing innovative agricultural technologies such as stress-signaling plants, microbial fertilizers, and protective seed coatings to adapt farming to climate change and enhance food security.

With global temperatures on the rise, agricultural practices must adapt to new challenges. Climate change is expected to increase the frequency of droughts, and some land may no longer be arable. Additionally, it is becoming increasingly difficult to feed an ever-growing population without expanding the production of fertilizer and other agrochemicals, which have a large carbon footprint that is contributing to global warming.

Now, scientists across MIT are tackling these issues from a variety of angles, including the development of plants that sound an alarm when they’re under stress and making seeds more resilient to drought. These technologies, and more yet to be devised, will be essential to feed the world’s population as the climate changes.

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Gases are essential for many chemical reactions, and bubbles are one way for these gases to be held in solution. When compared to larger bubbles, nanobubbles have increased stability—meaning that they can remain in a solution longer without popping. Due to their increased stability, they allow for higher availability of gases in solution, allowing more time for chemical reactions to occur.

Led by Dr. Hamidreza Samouei, researchers at Texas A&M University are advancing their understanding of what makes nanobubbles—bubbles with diameters smaller than a single strand of hair—so stable and what factors play a role in their stability. Their findings appear in a recent issue of The Journal of Physical Chemistry.

“When we inject gas at the industrial scale, we don’t want to waste that gas. We want to maximize its use for ,” said Samouei, a research assistant professor in the Harold Vance Department of Petroleum Engineering. “That’s the main purpose, to keep the gas in solution for a very, very long time, ideally infinite time; to keep the gas in solution without bursting.”

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