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At Abundance 360, David Sinclair made quite a number of encouraging comments about the future of aging research, including methods of resetting epigenetics to a youthful state

Emmett Short discusses these comments on this episode of Lifespan News.

But first, the mad scientist David Sinclair, this time with Peter Diamandis at Abundance 360, giving more details into human trials for the genetic engineering side of the technology versus the chemical and pill side of the technology. Which would you want more? We’ll also hear David’s thoughts on how AI will affect the advancement of this tech. Spoiler: A lot. I’m going to play the best parts and add my commentary along the way.

Alternative funeral options are changing how we honor our dead

When someone dies in the US, the vast majority of the time, their body is either embalmed, placed in a coffin, and buried in a cemetery, or cremated and the ashes returned to their loved ones in an urn — but those aren’t the only options.

A growing number of funeral directors, startups, and nonprofits are providing people with alternative ways to have their bodies honored after death — suggesting that the funeral landscape of tomorrow won’t be so binary.

Traditional burial and cremation has a cost for the environment, releasing chemicals into the ground or greenhouse gasses into the air, but a number of other funeral options are showing that death can be green.

Lung cancer awareness: The importance of early detection and treatment

Lung cancer is the third most common cancer in the U.S. and there have been more than 235,000 new cases of lung cancer in 2021. While this figure is significant, the rate of new lung and bronchus cancer cases is decreasing, in part because more people have stopped smoking. This trend, along with innovations in early detection and treatment, is also reducing the number of lung cancer deaths.

Dr. Robert Taylor Ripley, associate professor of surgery in the Division of General Thoracic Surgery, is an expert in mesothelioma and thoracic surgical oncology. In the following Q&A, he discusses common causes of lung cancer, risks and the latest treatments.

Q: What are the most common causes of lung cancer? A: Smoking cigarettes is the most common cause, but others include secondhand smoke and environmental inhalants. We see a fair number of patients with lung cancer who have never smoked. Exposure to diesel exhaust or other chemicals may also cause lung cancer in some non-smokers.

Melanoma Treating Soap: 14-year-old invents cancer-fighting soap

The Melanoma Treating Soap (MTS) was created using cancer-fighting chemicals, mainly Imidazoquinoline, integrated with a nanolipid-based particle transporter.

As child prodigies emerge in the world of innovation at younger ages than ever before, a 14-year-old student named Heman Bekele, residing in Fairfax, Virginia, developed a soap called MTS (Melanoma Treating Soap) to treat skin cancer.

Bekele’s efforts earned him the top prize in the 3M Young Scientist’s Challenge this year, a competition that motivates children to devise innovative solutions for common issues.

How nanobots and nanomedicine will improve our health

Nanotechnology sounds like a futuristic development, but we already have it in the form of CPU manufacturing. More advanced nanotech could be used to create independent mobile entities like nanobots. One of the main challenges is selecting the right chemicals, elements, and structures that actually perform a desired task. Currently, we create more chemically oriented than computationally oriented nanobots, but we still have to deal with the quantum effects at tiny scale.

One of the most important applications of nanotechnology is to create nanomedicine, where the technology interacts with biology to help resolve problems. Of course, the nanobots have to be compatible with the body (e.g. no poisonous elements if they were broken down, etc).

We dive into an interesting study on creating nanobarrels to deliver a particular payload within the bloodstream (currently in animals, but eventually in humans). This study is able to deliver RNA to cancer cells that shuts them down, without affecting the rest of the body. This type of application is why the market for nanotechnology keeps growing and will have a substantial impact on medicine in the future.

#nanotech #nanobots #medicine.

DNA origami nanobots – The University of Sydney Nano Institute.
https://www.sydney.edu.au/nano/our-research/research-program…obots.html.

ASU scientists have successfully programmed nanorobots to shrink tumors by cutting off their blood supply.

Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering

Regenerative medicine and tissue engineering strategies have made remarkable progress in remodeling, replacing, and regenerating damaged cardiovascular tissues. The design of three-dimensional (3D) scaffolds with appropriate biochemical and mechanical characteristics is critical for engineering tissue-engineered replacements. The extracellular matrix (ECM) is a dynamic scaffolding structure characterized by tissue-specific biochemical, biophysical, and mechanical properties that modulates cellular behavior and activates highly regulated signaling pathways. In light of technological advancements, biomaterial-based scaffolds have been developed that better mimic physiological ECM properties, provide signaling cues that modulate cellular behavior, and form functional tissues and organs.

OpenAI forms new team to assess “catastrophic risks” of AI

OpenAI’s new preparedness team will address the potential dangers associated with AI, including nuclear threats.

OpenAI is forming a new team to mitigate the “catastrophic risks” associated with AI. In an update on Thursday.

The team will also work to mitigate “chemical, biological, and radiological threats,” as well as “autonomous replication,” or the act of an AI replicating itself. Some other risks that the preparedness team will address include AI’s ability to trick humans, as well as cybersecurity threats.

We believe that frontier AI… More.


The preparedness team will address several potential threats.

Slow-moving quasiparticles make the fastest semiconductor in the world

It could improve limits on information transfer speed but is made of a super expensive ingredient that might make it financially infeasible.

Researchers at Columbia University in the US have developed the fastest and most efficient superconductor that works at room temperature, a press release said. The superconductor is made of superatomic material only known by its chemical formula, Re6Se8Cl2.

In a short span of time, silicon has become an integral part of most modern-day equipment ranging from cell phones to cars, computers to smart homes. However, scientists have found that silicon will soon reach its limits. This is because of the atomic structure of the semiconductor.

Adapting Ritalin to tackle cocaine abuse

Cocaine use continues to be a public health problem, yet despite concerted efforts, no drugs have been approved to resolve cocaine addiction. Research suggests that the attention-deficit/hyperactivity disorder drug methylphenidate (MPH; Ritalin) could serve as a cocaine-replacement therapy, but clinical results have been mixed. Although several labs have produced MPH derivatives for testing, parts of the molecule remained chemically inaccessible. Now, researchers reporting in ACS Central Science have cleared that hurdle.

According to the Centers for Disease Control and Prevention, more than 5 million Americans reported actively using cocaine in 2020, and almost 25,000 Americans died of a cocaine-related overdose in 2021. Although small-molecule drugs have proven effective in treating other drug addictions—for example, methadone as a therapy for heroin abuse—no such medication exists for cocaine abuse.

MPH has been considered a potential treatment because it behaves similarly to the illicit drug, increasing dopamine levels in the brain by blocking dopamine reuptake. Additionally, have shown that MPH has a lower risk of abuse than cocaine.

JWST captures immense, rare explosion

In March of this year, astronomers detected a brilliant burst of gamma rays more than a million times more luminous than our entire galaxy. It was the second brightest gamma-ray burst (GRB) ever detected and lasted some 200 seconds.

A study published today in Nature reports that this object was a collision of neutron stars one million light-years distant. What’s more, thanks to the James Webb Space Telescope (JWST), astronomers were able to see that the blast also served as a cosmic chemical factory, forging some of the rarest chemicals found on Earth.

“The most robust evidence that the merger of two neutron stars caused this burst comes from its kilonova,” says lead author Andrew Levan of Radboud University in the Netherlands, referring to the optical and infrared light coming from the uber-sized explosion.

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